40 Speakers & Agenda • Long-term COVID Protocol • APOE4

Your sneak peek into the world of Longevity Docs.

Sep 29, 2024

Hi Longevity Docs,

Next weekend, over 100 physicians will gather in NYC to shape the future of Longevity Medicine! With 40 leading experts presenting the latest protocols, therapies, innovations, and research, it’s set to be an epic experience. We've also built in plenty of community time, giving doctors from around the world the chance to connect, collaborate, and support one another. Can’t wait to see everyone there!

This week in our newsletter:

Mastermind:

Meet the Speakers
Discover the Agenda

Buzz in the Chat:

Protocols for preventing long-term COVID sequelae
Protocols for APOE4 positive patients?

Publications:

Urinary Metal Levels and Coronary Artery Calcification
The Global Pattern of Centenarians Highlights Deep Problems in Demography
Effect of Psilocybin Versus Escitalopram on Depression Symptom Severity

Press:

The Gut Might Hold the Key to Treating Long Covid in Kids - Wired
What is Rapamycin? Devotees Claim the Drug Can Slow Aging - NY Post
Stem Cell Treatment Promises to Prevent Disease and Slow Aging - Newsweek

Healthy Sunday!

David

Reflexion: “Thank you dad for spending the day with me” was the gift of the week. Attention is priceless and the most precious gift you can offer your loved ones. That’s why I want to live longer: to collect more of those priceless moments.

🚨 News

🎤 Discover an unforgettable Mastermind experience

We've curated an unforgettable experience for this edition of the Mastermind with more than 40 speakers, designed exclusively for our community of doctors. Get ready for deep educational dives, open conversations with inspiring leaders, and unique networking opportunities in the heart of NYC:

Education:

Classroom: deep dives into hots topics with our experts
Mastermind: open convo with inspiring masterminds
Boardroom: a chance for every doctor to ask questions and contribute ideas

Networking:

The Tour: Visit a cutting-edge longevity destination in NYC
The Club: an invite-only dinner at one of NYC’s trendiest hotspots

Agenda

Are We Ready for Longevity Medicine?
Zahi Fayad, PhD
Building Emotional Resilience—Caring for Yourself as a Doctor
Tamsin Lewis, MD
Mitochondrial Power: Optimizing Gut, Skin, and Muscle Health
Anurag Singh, MD; Neil Paulvin, DO; Frank Lipman, MD, Poonam Desai, DO
Peptides & NAD: Miracle Molecules or Overhyped?
Elizabeth Yurth, MD
Men’s Health & Testosterone: Rethinking Therapy for the Younger Patient
Tracy Gapin, MD; Desmond Ebanks, MD; Shalin Shah
Plasmapheresis & HBOT: Are These Cutting-Edge Therapies Worth It?
Jonathann Kuo, MD; Alan Katz, MD; Dobri Kiprov, MD
Mastermind: From Crisis to 48 Franchises
Darshan Shah, MD; David Luu, MD
Compounded GLP-1: What’s the Current Landscape?
Leonard Pastrana, PharmD
Are Digital Clinics the Future of Longevity Medicine?
Saad Alam
Organ Age—How Far Have We Come?
Alina Rui Su
Leveraging Data to Transform Your Longevity Clinic
Wei-Wu He, PhD
Grow Your Clinic—Fundraise, Acquire, or Exit?
Are Doctors the New Influencers?
Amy Killen, MD; Vonda Wright, MD; Catherine Johnson, MD; Poonam Desai, DO
Heart Disease: Should It Be Our Top Longevity Priority?
Giovanni Campanile, MD; Abid Husain, MD
Stem Cells: From Research to Reality
Steven Murphy, MD; Mattias Bernow, MD; Rikin Patel, DO
Long Haul COVID: Are We Ready to Tackle Protocols and Treatments?
Robin Rose, DO
Women’s Health: Should We Fear HRT, or Is It a Key to Longevity?
Amy Killen, MD; Vonda Wright, MD; Felice Gersh, MD; Florence Comite, MD
Are Off-Label Therapies Safe and Efficacious?
Sajad Zalzala, MD; David Barzilai, MD, PhD
Exosome 101: What Is It All About?
Pradeep Albert, MD
AI Scribe: Is This the End of Doctor Notes?
Margaux Benoit
Longevity EMR: Enhancing Patient Experience
Daniel Whitlock
Vaginal Microbiome Testing: The Future of Personalized Women’s Health?
Priyanka Jain
AI Education: A PubMed in Your Pocket
Robin Roumengas
Is Continuous Stress Monitoring the Key to Disease Prevention?
Marina Pavlovic Rivas
Career Pivot: Is Fear Holding Physicians Back from New Opportunities?
Jila Senemar Meyer, MD; Sharon Golberg, MD; Erika Klemperer, MD; Louis de Palo, MD
The Future of Longevity Medicine: What Do Young Doctors Want to Know?
Amanda Khan, MD

🚨 Only 19 Tickets Left! 🚨

Don’t miss your chance to join the top experts in longevity medicine. Exclusive access to cutting-edge treatments, networking, and strategies to elevate your practice. Don’t be left behind—act now!

👉 Get your ticket before it’s too late!

✊ The Longevity Docs Collective

The Longevity Docs Collective is curated network of partners that gives Longevity Docs privileged access to the coolest, cutting-edge solutions in longevity. Think private invites to the hottest product launches, first dibs on partnership deals, and unique chances to test and tweak the latest breakthroughs. It's the ultimate hub for those looking to lead and redefine the future of longevity medicine.

Our first cohort of partners includes:

Timeline is committed to delivering clinically proven products to promote cellular rejuvenation and healthspan.
Marius Pharmaceuticals is paving the way for a new frontier in testosterone
Cellcolabs’ mission is to prevent and treat diseases by making high quality stem cells available and affordable
Nubioage is the leading cellular medicine platform
Human Longevity is the pioneer of longevity clinics
Hone Health telehealth services that support hormone health and longevity
Generation Lab offers biological age for 19 different organs and systems
Nabla is the leading ambient AI assistant for clinicians
Extension Health is New York ultimate longevity destination
Hearty is the Longevity Medicine Platform for concierge doctors
Juisci is the AI-Companion for your Continuing Medical Education.

💬 Buzz in the Chat

What is everyone’s protocol or personal prescription to help prevent long term sequelae of COVID, whether you’ve had it or not, vaccinated or not.

Here is what I do and it started with during infection:
- 1) clear virus (pax x10 vs Truvada) (metformin 1000AM/500pm)
- 2) Clear bacteriophage activity (Augmentin vs Amox/Xifaxan)
- 3) stop coag probs (check d dimer, CRP, etc) ASA a must plus/minus natto (I lean towards things that bust up fibrin) if d-dimer >2 I am using lovenox
- 4) mito support acutely Q10/ALA/Carnitine (I use 1MNA after.
Now after infection
- 1) probiotics (5 strain bifidus)
- 2) continue metformin, senolytic, etc (I know some use amlexanox here, I haven’t yet)
- 3) assess damage to hallmarks of aging and treat
You must stop mito senescence, immunosenescence, endothelial inflammaging, iron dysfunction, Endo problems, fibrin triggers, neuro inflammatory triggers, stem cell senescence, thymus destruction, kidney disease and a host of other problems once it sets in. So I am a big fan of Truvada even post symptoms to eradicate reservoirs, with the HIV DATA you have a limited window of 12-18 months to do this. Prevention is essential. Lastly, I do use rapamycin in my cases and consider Dasatinib too with Quercetin for senolytic effects. But you have to tailor much to the patient’s protoplasm to begin with.
Agree! RR’s protocol and info has been amazing for active infection. And have been utilizing. It’s the long term and the exposures/infections that are mild that one may not even realize they had. The daily must do’s and prevention. I know gut health-crucial, hormonal optimization, metformin/GLPs, etc.
Thanks S.! I deal a little differently. Agree with doxy and i use LL37 as an aggressive natural antiviral. But ll37 binds the NETs (neutrophils extracellular traps) that binding to fibrin and rbcs and create clots. I also use pentosan since great antiviral but also prevents clots, stabilizes vascular endothelial, improves microcirculation, inhibits histamine...I also start bpc/ kpv to normalize healing, reduce platelet stickiness, dilate blood vessels, prevents plaque. I start ta1 and tb4 daily for a few weeks. But the big issue with covid and other viruses like ebv is they hijack mitochondria! They do this by increasing nnmt so I think have to block nnmt! 4 caps 1mna daily. Probably there is more of an oxidative storm than cytokine storm!! So ketone esters help support atp and short course of motsc or ss31.
That’s the best part. We all bring different strokes. The problem with covid is it attacks everything. But not everything in everyone at once. So we need to pool our knowledge here IMHO. That’s what I’m so excited about the next mastermind and onward. I truly believe our group of docs has more knowledge about how to defeat this scourge than all the ivory towers put together (I came from one) I’m certain we have the tools!
Agree!!! Love the depth of knowledge and discussion!!! Best group ever 💖💖💖

Protocols for APOE4 positive patients?

Avoid head impact sports
Eat caviar
Nose breathing
DHA, not EPA
Sauna
Glutathione
Acetylcholine
Dr Goodenowe has been studying apoe4 using plasmalogens erythrocyte ba group at Rush for over 15 years and if keep plasmalogen levels high, nine are progressing to cognitive decline! Also check galactic 3 levels. Often high in apoe4 people. If high use pectasol to lower
The point is to emphasize DHA intake over EPA, especially before disease onset. ApoE4 alters delivery of DHA to brain by increasing phospholipases; hence the need for higher concentrations than one would usually expect.
How do you give acetyl choline? Which supplement do you use? For glutathione - do you use oral form? If yes, which one? Liposomal?
Is oral glutathione worth giving or is there very limited GI absorption to increase intracellular levels? I usually give NAC as precursor to increase glutathione levels, but also as I don’t do IVs in the clinic ourselves
I heard differing opinions on liposomal and absorption. We do iv in the clinic but I was curious about Dr JS protocol for APOE4 and what type of glutathione
Boost/support acetylcholine levels:
•⁠ ⁠eat choline rich foods
•⁠ ⁠⁠Phosphatidylcholine by body bio
•⁠ ⁠⁠prodrome glia-pc or neuro-pc
•⁠ ⁠⁠alpha gpc
•⁠ ⁠⁠anything that increases bdnf
•⁠ ⁠⁠avoid anti-cholinergic pharmaceuticals

🩺 Publications

Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis

JACC - Recommended by Dr. Steve Murphy

Exposure to metals was generally associated with extent of coronary calcification at baseline and follow-up. These findings support that metals are associated with the progression of atherosclerosis, potentially providing a novel strategy for the prevention and treatment of atherosclerosis progression.

The global pattern of centenarians highlights deep problems in demography

Medrxiv - Recommended by Dr. Hillary Lin

These patterns suggest a persistent inability, even for nation-states or global organisations, to 30 detect or measure error rates in human age data, with troubling implications for epidemiology, demography, and medicine.

Effect of psilocybin versus escitalopram on depression symptom severity

eClinicalMedicine (Lancet) - Recommended by Dr. Carlos Gutierez

The study concluded that both psilocybin and escitalopram, when combined with psychological support, led to long-term improvements in depressive symptom severity for patients with major depressive disorder. However, the psilocybin treatment group showed greater improvements in psychosocial functioning, meaning in life, and psychological connectedness at follow-up, suggesting the need for further research.

🗓️ Events & conferences

👉 Longevity Docs Mastermind: NYC - October 5,6
Biomarkers of Aging Conference - November 1-2, Boston, MA
Longevity Summit - December 3-4, Novato, CA
Roundtable of Longevity Clinics - December 6-7, Novato CA
A4M Fest - December 13-15, Las Vegas
Cannes Longevity Festival: Cannes, France - June 25,27 2025

About Longevity Docs Mastermind

The Longevity Docs Mastermind is a physician-only event focused on precision and evidence-based longevity medicine. This is where the medical leaders of today shape the future of longevity.

New York City - October 5-6, 2024

Convene 101 Park Avenue, NYC

Book Your Ticket Now