The End of GPs? • Tech for Hot Flashes • NDA+ patches • Why VC-Backed Longevity Startups Are Dying?
Issue 55: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
This week, something clicked for me.
It wasn’t in a clinic, or in a conference, but around a fire, with friends.
A simple conversation made me realize just how fast the world is moving beyond traditional medicine.
And how quickly people are turning to each other, to AI, to Google, to biohacking communities before they ever think of calling a doctor.
I don’t see it as a threatthis is evolution. And it should be a wake-up call for all of us.
In this week newsletter:
Inside Longevity Docs: We have readers in 100+ countries and why it matters
Buzz in the Chat: Does NAD+ Patch Therapy Work?
Cover Story: GPs Are Facing Extinction
Research Radar: Dietary patterns • Osteoporosis Review • Microplastics in the Air • Therapeutic apheresis for microplastics
Longevity Intelligence: Eight Sleep Launches New Hot Flash Mode • Nudge Announces $100M Series A for Non-Invasive Brain Interfaces • Sava Technologies raises €16.6 million for its wearable microsensor technology
Longevity in the News: Why VC-Backed Longevity Startups Are Dying In A $5 Trillion Wellness Market • Why Regenerative Farming Is the Latest Wellness Travel Trend
Healthy Sunday!
PS: This is where I found clarity today: Peconic Bay in the Hamptons always resets my thinking.
We have readers in 100+ countries: From Namibia to Switzerland: Why This Matters
This is a milestone I wanted to share with you
This is Longevity Docs Newsletter #56
Today, we’re 3,137 subscribers strong.
We’ve reached 44 U.S. states and 103 countries.
And our open rate? A steady 60.05%.
From physicians in Mumbai and Melbourne to entrepreneurs in Berlin and investors in São Paulo… we’re proving something powerful:
Science-backed longevity medicine content matters.
We’re democratizing access to longevity medicine education, research, tech, investment news, and clinical best practices, without bias, fluff, or clickbait.
And we’re just getting started.
By this time next year, my goal is to reach every country in the world so that every doctor, no matter where they practice, has a seat at the table and be part of the longevity medicine movement.
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Does NAD+ Patch Therapy Work?
A patient’s question about NAD+ patches sparked an intense thread and revealed the cracks in current delivery methods. Here's the pulse:
NAD+ via Iontophoresis patches (e.g., IontoPatch) are marketed for convenience and absorption, but physicians remain skeptical:
“No data on it—and if it’s NAD+, then not helpful.” NP
“Major downside is a rash patients tend to get from iontophoresis.” SZ
“NAD is not supposed to be in your veins roaming around freely... the conversion to NMN or NR is necessary first.” DS
Key concern: even if it enters the bloodstream, there's no clear evidence it crosses the cell membrane, where NAD+ actually needs to be to function metabolically.
IV NR > IV NAD?
A growing number of doctors are shifting to IV Nicotinamide Riboside (NR) as a more patient-friendly and biologically efficient alternative to NAD+ drips.
“NR absorbed more quickly and reduces a 3-hour IV to 45 minutes.” DS
“I do several months of NR, then switch to 1-MNA.” NP
The Rise of 1-MNA & Apigenin
1-Methylnicotinamide (1-MNA), often paired with apigenin, is drawing clinical attention for its role in blocking the enzymes that degrade NAD+, thus preserving intracellular levels.
“Increased breakdown—rather than reduced production—is the real issue.” DE
“It also supports the methylation pathway by decreasing SAMe consumption.” PD
These are now becoming cornerstone molecules in advanced NAD optimization protocols.
Oral Precursors Still Reign
Clinicians continue to rely on oral NR or NMN, citing better safety, compliance, and evidence, especially in combination with personalized genomic or detox data.
“I use NAD precursors such as NR or MNN. Several articles on PubMed show NAD struggles to cross the cell membrane.” MY
Takeaways for Longevity Docs:
Skepticism is warranted around NAD+ patches and IVs unless data validates intracellular uptake.
IV NR is gaining favor for efficacy, speed, and tolerability.
1-MNA + Apigenin may be the new go-to duo for preserving NAD+ levels by slowing breakdown, not just boosting production.
Think intracellular, not just bloodstream delivery: absorption ≠ utilization.
Ready to Learn About the Peptide Revolution?
📍 New York City | October 4, 2025 | Convene 101 Park
👥 In-person seats are highly limited to preserve depth, exclusivity, and real connection.
General Practitioners Are Facing Extinction
A Personal Wake-Up Call
This weekend, around a beach bonfire, I told my friend he looked great. He’d dropped weight, had more energy, and seemed sharper. His reply stopped me:
“My wife figured it all out: peptides, supplements, red light, fasting protocol, all of it…..“
She’s not a doctor. Not a nurse. Not a health coach.
Just someone curious enough (and empowered enough) to do what many GPs were trained for. And to be honest, she did it better than most physician could in a 15-minute insurance-covered visit.
That moment hit me hard.
The role of the GP, the doctor as default, as gatekeeper, as guide, is quietly disappearing.
And I think it’s time we admit it. Not to be cynical. But to act.
10 Reasons GPs Are Being Replaced
And Why Every Doctor Will Be a Longevity Doctor Soon
AI is the new differential diagnosis
Patients now test their symptoms with GPT before they ever call your office. And it’s often… more accurate.Direct-to-consumer labs have cut us out
Anyone can order advanced panels, gut tests, hormone data, and methylation clocks, no doctor needed (and most companies offer a report, accurate or not)TikTok is today’s family physician
Biohackers, wellness creators, and functional coaches are giving people hope, protocols, and community. No license, no problem.Patients read scientific papers
The idea that we "own" medical knowledge? That’s gone. People are citing studies before you do.The high-demand GPs have gone concierge or cash-pay
Unlimited access, deep testing, preventive care, community. They don’t take insurance.Urgent care owns the acute lane
They’re faster, cheaper, open late, and don’t make people feel like a number. The GP is rarely called.Employers are bypassing primary care altogether
They want outcomes so they’re contracting directly with health optimization startups and skipping the middle.People don’t want to be managed, they want to be upgraded
The one-size-fits-all era is over. Everyone wants a custom plan. A N=1 protocol. The era of the white coat power is over.
So what now?
We can either cling to what was or lead what’s next.
Longevity medicine isn’t a fringe niche anymore. It’s becoming the new foundation of healthcare.
The GPs of tomorrow?
They won’t just treat disease. They’ll teach people how to never get there.
They’ll read omics data. They’ll understand functional testing. They’ll prescribe purpose, light, movement, and peptides when needed.
We call them Longevity Docs.
Some are already making the leap. Others are quietly watching from the sidelines. But one thing’s certain:
📉 The GP is going extinct.
📈 The Longevity Doctor is rising.
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Dietary patterns and accelerated multimorbidity in older adults
A 15-year study published in Nature Aging followed 2,473 older adults and found that those who adhered to anti-inflammatory diets like MIND, AHEI, and the Mediterranean Diet accumulated chronic diseases significantly more slowly—especially cardiovascular and neuropsychiatric conditions. In contrast, pro-inflammatory diets (measured by EDII) accelerated disease accumulation. The benefits were strongest in women and adults over 78. These findings reinforce the power of diet to influence not just individual conditions, but the overall pace of aging.
Osteoporosis - A Review
Osteoporosis is a common condition among older adults that leads to increased susceptibility to fracture, which is associated with substantial morbidity and mortality. Antiresorptive agents such as bisphosphonates or denosumab are recommended for patients at high fracture risk. Anabolic treatment with parathyroid hormone analogs (such as teriparatide and abaloparatide) and sclerostin inhibitors (such as romosozumab) can be considered for very high-risk individuals. JAMA
Human exposure to PM10 microplastics in indoor air
A new study reveals that we may inhale up to 68,000 microplastic particles per day, most of them tiny fragments smaller than 10 microns, especially in indoor environments like homes and car cabins. These particles are small enough to reach deep into the lungs and potentially enter the bloodstream, carrying harmful chemicals that can disrupt hormones, trigger inflammation, and increase long-term health risks. With indoor air now recognized as a major—and previously underestimated—source of microplastic exposure, researchers are calling for more routine monitoring and better indoor air quality strategies to protect our health. PLOS One
Therapeutic apheresis: A promising method to remove microplastics?
Microplastics and nanoplastics have emerged as a major and growing health concern, with recent data revealing alarming levels of human exposure and contamination. Thus, there is a clear and urgent need for an effective method to remove microplastics and nanoplastics from the human body. Here, we provide the first evidence that extracorporeal apheresis, a therapeutic technique established around the world, may have the potential to achieve this goal. Brain Med
Eight Sleep Launches New Hot Flash Mode to Improve Sleep for Every Stage of Life
Eight Sleep launched a multi-year Women’s Sleep Initiative, starting with a new “Hot Flash Mode” designed to cool the bed instantly and relieve nighttime hot flashes—a major menopause symptom that affects 80% of women but is rarely addressed in clinical sleep tech.
Nudge Announces $100M Series A for Non-Invasive Brain Interfaces
Startup Nudge just raised a $100M Series A (led by Thrive Capital and Greenoaks) to pioneer non-invasive brain interfaces—aiming to treat deep-brain disorders like depression, PTSD, addiction, and chronic pain without surgery or drugs.
Sava Technologies raises €16.6 million for its wearable microsensor technology
Sava Technologies Ltd., a British MedTech startup innovating real-time molecular health monitoring, today announced €16.6 million in Series A funding to accelerate regulatory approval and commercialisation of its next-generation wearable. The round was led by Balderton Capital and Pentland Ventures,
Deepak Chopra to Launch Wellness Innovation Hub in Utah
Deepak Chopra is launching a $180 million wellness resort in Utah that will integrate geothermal healing, luxury living and AI-powered health technology.
Would You Pay $13,000 to Rid Your Blood of Microplastics?
Clarify Clinics is a British-based start-up offering a procedure it claims can remove microplastics from one’s blood — for around $13,000. The Cut
Why VC-Backed Longevity Startups Are Dying In A $5 Trillion Wellness Market
Consumer interest in longevity and wellness has never been higher—with the global wellness market valued at over $5 trillion and VC funding in health tech and wellness surpassing $40 billion in recent years—yet startups in the space are collapsing. The disconnect highlights a deeper issue: venture capital’s fast-growth expectations are misaligned with the slow, trust-based nature of healthcare and prevention. Forbes
Maryland calls its multisector plan for aging a national model in longevity readiness
Longevity Ready Maryland is a 10-year strategic plan that launched Wednesday after being signed by Gov. Wes Moore (D). Maryland Department of Aging Secretary Carmel Roques said during a news conference that the plan was designed to ensure that Marylanders can age with dignity, purpose and independence through an all-of-government, multi-sector approach. Mc Knights Senior Living
The Longevity Dividend: How Aging Populations Are Reshaping Global Investment Strategies
Geroscience and AgeTech innovations (e.g., senolytics, AI eldercare) target aging at cellular and societal levels, with $200B+ biotech investments by 2030. AInvest
The best way to age? Forget the longevity bros – and be more Mariah Carey
The singer has a reputation for cancelling anything she takes against, from stairs to overhead lighting. When it comes to our increasingly toxic obsession with wellness, she’s absolutely right. The Guardian
Why Regenerative Farming Is the Latest Wellness Travel Trend
The newest frontier in wellness tourism isn’t another luxury spa—it’s the farm. Across the globe, high-end regenerative farm stays are redefining longevity retreats. Merging biodynamic agriculture, Michelin-level cuisine, and five-star design, this new wave of agritourism is rooted in more than aesthetics—it’s about reconnecting to nature, purpose, and the rhythms of life. Vogue
Longevity Conferences Calendar
ARDD: Copenhagen, August 25-29
Nubioage Clinical Longevity Summit: West Palm Beach, September 12-13, 2025
Longevity Investors Conference: Gstaad, Switzerland, September 22-25
Longevity Docs Peptides Mastermind: New York, October 4
Health Optimization Medicine Symposium: Boulder, October 17-18
Zenos Health Summit: Riyadh, October 23-25, 2025
Longevity Clinic Roundtable: Novato, December 6-8, 2025
A4M: Las Vegas, December 12-13
Longevity Docs Cannes: June 10-11, 2026
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
We’re not just witnessing the transformation of longevity medicine we’re building it. Together.
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.
Such an important shift—and absolutely a step in the right direction.
But the reality is, there still aren’t enough longevity docs.
And GPs have become gatekeepers to things that shouldn’t be gates in the first place.
Too often, their role is to say something’s “not indicated”—which really just means “you’re not sick enough yet.”
That’s not care. It’s delay.