Smarter Labor, More YOHL • The Longevity Docs Tables launches in the US • Exosomes compliance • Plaque vs Cholesterol
Issue 60: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
It’s Labor Day in the US: a time we’re supposed to celebrate rest.
And then I thought: maybe we don’t need more rest.
Maybe what we really need is to work smarter.
To be more productive.
To leverage tech, research, community, and education.
To build practices that actually lead to better outcomes for our patients.
Because at the end of the day, there’s only one metric that counts at Longevity Docs:
How many years of healthy life (YOHL) did we add to society?
Let’s keep going.
Let’s work smarter.
Let’s add years.
Wishing you a healthy Labor Day weekend!
Dr. David Luu
Founder, Longevity Docs
www.longevitydocs.org
In this week newsletter:
🟢 Inside Longevity Docs: Table Launch • Peptides Speakers
💬 Buzz in the Chat: GLP-1s & Hair Loss • Exosomes Compliance
📰 Cover Story: Labor Day for Longevity Docs – Work Smarter, Not Harder
🧠 Research Radar: Gum & Vascular Aging • Plaque vs Cholesterol • Ultra-Processed Food & Fertility
🌎 Longevity in the News: Women & Aging • Medical Tourism Trends • Mark Cuban vs. Big Pharma
🚀 Longevity Intelligence: Mouth-Based Sensors • AI for Stem Cell Reprogramming • Gates Tackles Alzheimer’s
Our team is hard at work, and I’m excited to share what’s happening behind the scenes across the Longevity Docs ecosystem.
Big Announcement
The Longevity Docs Table Launch – NYC, September 11
After traveling and meeting so many of you this year, one thing became clear:
We need more space to connect, share, and learn from each other.
Off stage, off screen, and in real life.
That’s why we’re launching Longevity Docs Tables
This new series of private, physician-hosted roundtables blends the intimacy of a dinner with the depth of a clinical discussion.
The first Table kicks off at my home in New York City with my dear friend Dr. Frank Lipman on how to build a concierge longevity practice.
From there, we’ll bring them to cities across the country; creating space for small, curated groups of physicians to sit down, trade insights, and build the future of longevity medicine together.
By invitation only (limited to 16). Let us know if you’d like a seat at the Table.
Backstage Updates
Members
Dr. Naisohn Arfai launches his longevity practice in Miami
Last week, I launched my own solo longevity practice in Miami: HAYA Precision. HAYA stands for Healthier As You Age. I saw my first two patients last week, and I feel more energized than I have in years.
After two decades in Emergency Medicine, most recently as Director of Quality for the Emergency Department at Jackson Memorial Hospital in Miami and as AOA Faculty, I’ve seen firsthand what it looks like when disease has already taken its toll.
That’s why being part of this new field is so inspiring to me. Longevity medicine is about shifting the focus from reactive care to true prevention and health optimization.
The Longevity Docs Summit and the community represent the kind of paradigm shift that so many of us in medicine have been waiting for. The spirit of innovation, and the collaboration across disciplines (medicine, business, industry) it’s a breath of fresh air. It gives me real hope for the future of healthcare, which has been stuck in an old model for far too long.
The Longevity Docs Certification program has helped me build my practice on a very solid, scientifically grounded foundation, bringing the best insights from the frontiers of medicine.
There’s something about the momentum in this movement that makes me excited to be a doctor again. I’m here for it, and I plan to stay involved for many decades to come. Honestly, I feel 20 years younger.
Certification
Unit 8 is now live, with new faculty-led sessions rolling out this fall.
We are working on our LMS upgrade to improve the user experience.
CLP Cohort 2 is now full. Cohort 3 is coming soon. Learn more
Events
📍 Table NYC — September 11
📍 Peptides Mastermind, NYC — October 4
We’re thrilled to welcome two leading voices in longevity medicine to the Peptides Mastermind, NYC — October 4:
Dr. Matt Cook: Founder of BioReset® Medical, recognized for pioneering peptide and regenerative therapies that bridge science with real-world practice.
Dr. Saranya Wyles: Mayo Clinic physician-scientist advancing regenerative medicine and aging biology, with a special focus on skin aging and translating peptide science into clinical care.
📍 AI Mastermind, NYC — February 17, 2026
We’re entering one of the most transformative eras at the intersection of AI and medicine.
Know a Speaker we should feature? Reach out to bailey@longevitydocs.org.
Interested in Partnering? Contact meriem@longevitydocs.org.
Where We’re Speaking
We’re proud to share the Longevity Docs mission at some of the world’s leading platforms:
Inside Wellness & Beauty Forum, New York — September 17
Vibrant Summit, Austin — September 24–27
Zenos Summit, Saudi Arabia — October 23–25
Galien Forum, New York — October 30
Come say hi!
Each week, I try to explore one idea that could advance longevity medicine and hopefully support physicians in bringing it to life.
Less Labor, More Longevity
This Labor Day weekend is a reminder of why we built this community: to make the practice of longevity medicine sustainable, credible, and collaborative. While most of the world celebrates labor by taking a break, we’re reflecting on the future of physician work and how Longevity Docs is helping doctors work smarter, not harder.
Labor Day was born out of the late 19th-century labor movement in the United States. It honored the contributions of workers, fought for better conditions, and redefined what fair labor looked like in a modernizing world. Fast forward to today, the same ethos applies to medicine: physicians are working longer hours, burning out, and navigating broken systems. Longevity Docs exists to help physicians build practices that honor their expertise, time, and wellbeing.
We talk to dozens of physicians every week and this is what we learned
Evidence & Credibility
CME-accredited education and certifications to legitimize longevity practice.
Trusted data, protocols, and peer validation (skepticism about hype in peptides, GLP-1s, supplements).
Community & Collaboration
Real-time knowledge-sharing via WhatsApp
Access to colleagues for case consults, dosing guidance, and practice strategies.
Career & Practice Transitions
Many are pivoting from emergency medicine, OB/GYN, anesthesiology, pain, or functional medicine into longevity.
Need guidance on moving from insurance-based to cash-pay models.
Business Infrastructure
Help setting up private practices, tech platforms, patient acquisition, and marketing strategies.
Desire for structured mentorship, practice shadowing, and community-driven referrals.
Clinical Protocols
Clear dosing, case examples, and safe integration of peptides, hormones, regenerative therapies (stem cells, PRP, NAD+).
Better frameworks for lifestyle interventions, prevention, and root-cause medicine.
Labor Day was created to honor the people who build.
At Longevity Docs, that’s exactly what we’re doing; advancing longevity medicine from the inside out.
Not by grinding harder.
But by getting smarter.
By choosing collaboration over isolation.
Evidence over hype.
And systems that actually support doctors and patients.
Because at the end of the day, there's only one metric that matters to us is how many YOHL we add to our patients.
This is unfiltered look at the most engaging conversations happening in our Longevity Docs WhatsApp group.
GLP-1 watch: hair loss, auto-refills, and dose strategy
Notable uptick in telogen shedding (esp. tirzepatide), likely from rapid weight loss + protein/micronutrient gaps.
What docs do: protein targets, iron/multi, platelet topical, red-light, Nutrafol/Xtresse; consider micro-dosing during aggressive loss.
Multiple reports of LillyDirect auto-refills despite “0 refills” in notes, teams flagging for patient education.
Exosomes & biologics compliance
Members shared fresh FDA warning letters
Strong consensus do not inject exosomes for derm/MSK outside appropriate pathways
Many market products are EV-rich/conditioned media rather than bona fide exosomes.
Vendor diligence and website language are critical.
Brain fog / POTS toolbox
Methylene blue (4–25 mg) might show signal, Modafinil (50–200 mg) as a short-term “reboot” while you treat root causes; LDN, GLP-1 (select cases), and a mito stack (1-MNA, SS-31, carnitine, creatine, ETC support).
Niagen IV vs NAD drips
Some claim quicker infusions, fewer sides reported vs NAD
But members push for how we measure impact and tie it to outcomes (not just serum nudges). If we can’t measure it, we can’t scale it.
Join 500+ Longevity Docs Across 50 Countries
Longevity Docs is a highly vetted, invitation-only community for physicians shaping the future of longevity medicine.
Apply online and connect 1:1 with our team
Each week, I highlight a few studies that caught our eyes and could shape the future of longevity medicine.
Gum Health & Vascular Aging
A 2-year RCT (European Heart Journal) in 135 patients showed intensive periodontal treatment reduced carotid intima-media thickness and improved endothelial function versus standard care. Inflammation markers also dropped. Treating gum disease may directly slow vascular aging, making dental health a critical lever in cardiovascular longevity care.
👉 Question for Longevity Docs: If treating gum disease slows vascular aging, should dental health be part of every cardiovascular longevity conversation?
Plaque vs Cholesterol
A JAMA cohort of 23,143 symptomatic adults showed that even patients with severely elevated LDL-C had low ASCVD and death rates if both CAC and noncalcified plaque were absent. Risk climbed in proportion to plaque burden, not cholesterol level alone.
👉 Question for Longevity Docs: Soft plaque and CAC remain debated, should they become the new standard in cardiometabolic assessment or at least be discussed with every patient?
Ultra-Processed Food & Fertility
A controlled crossover trial in Cell Metabolism shows that ultra-processed diets (even without extra calories) increase weight, worsen LDL:HDL ratios, lower key metabolic and reproductive hormones (incl. FSH), and impair sperm motility, with pollutant shifts (phthalates ↑).
👉 Question for Longevity Docs: If food processing is a biomarker of aging and fertility risk, should we be debating food quality (not just calories) with every patient?
I comb through the mainstream headlines, handpick the most relevant longevity stories.
The New Rules Of Longevity: Why Women Need A Completely Different Approach To Aging
Aging well isn’t about expensive biohacks, it’s about fundamentals like hormones, muscle, bone, and brain health, especially for women navigating menopause. Experts stress that longevity shouldn’t be gamified into a competition but embraced as a privilege, with proactive choices driving real healthspan gains. Women’s Health
The Future Of Wellness: Top Trends In Longevity & Medical Tourism
According to the Global Wellness Institute, the desire to live healthier, longer lives is fueling the trillion-dollar wellness and medical tourism industry. Research from Booking.com echoes this, showing that travelers increasingly prioritize trips that enhance their overall wellbeing. Forbes
Mark Cuban’s war on America’s $5 trillion healthcare machine: ‘They can’t react as quickly’
Most drug prices today are set by pharmacy benefit managers (PBMs), or third parties that manage prescription drug programs. Cuban said drug prices are opaque by design. That’s exactly why he launched Cost Plus Drugs in 2022 — to pull back the curtain on drug pricing, bring down costs to the average consumer, and disrupt the traditional pharmacy industry. TechCrunch
Every week, I track the biggest moves in longevity: new funding rounds, partnerships, product launches, and key hires.
Lura Health Advances Mouth-Based Health Monitoring Technology
Lura Health has partnered with Japan’s SCO Group to deploy sensor technology that monitors health through the mouth. The collaboration will advance Lura’s microsensor technology through clinical validation and expand applications globally.
Lura Health develops wearable microsensors that attach to dental appliances or teeth to collect real-time health data including pH levels and other markers in saliva. The technology aims to monitor whole-body health through the mouth.
OpenAI and Retro Biosciences achieve 50x increase in expressing stem cell reprogramming markers.
“We are excited to share that we’ve successfully leveraged GPT‑4b micro to design novel and significantly enhanced variants of the Yamanaka factors, a set of proteins which led to a Nobel Prize for their role in generating induced pluripotent stem cells (iPSCs) and rejuvenating cells. They have also been used to develop therapeutics to combat blindness, reverse diabetes, treat infertility, and address organ shortages. “ OpenAI
Bill Gates Launches $1M A.I. Competition to Tackle Alzheimer’s
Bill Gates and a coalition of partners are backing a new A.I. competition designed to spur breakthroughs in Alzheimer’s and related dementia research. Observer
Longevity Docs Peptides Mastermind
New York City | October 4, 2025
Learn from the experts: from Peptides 101: What Every Longevity Doctor Must Know to Risks, Ethics & Regulation
Longevity Docs Summit Cannes
Cannes, France | June 10-11, 2026
Conferences Calendar
Nubioage Clinical Longevity Summit: West Palm Beach, September 12-13, 2025
Longevity Investors Conference: Gstaad, Switzerland, September 22-25
Longevity Docs Peptides Mastermind: New York, October 4
Health Optimization Medicine Symposium: Boulder, October 17-18
Zenos Health Summit: Riyadh, October 23-25, 2025
Longevity Clinic Roundtable: Novato, December 6-8, 2025
A4M: Las Vegas, December 12-13
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
We’re not just witnessing the transformation of longevity medicine we’re building it. Together.
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Stay connected with the backstage of the Longevity Docs community, a network of over 400 physicians spanning 50 countries, united in our mission to democratize longevity medicine. Explore the latest in evidence-based longevity care, gain exclusive access to physician insights, and join us in shaping the future of this transformative field.
Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.