Peptides Masters • Lithium and Alzheimer • Oral GP1s • CGMs war
Issue 57: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
Back in New York City, it feels good to be home. Every Sunday, I’m amazed by the new conversations, products, companies, and conferences popping up in the longevity space. It seems like everything is becoming “longevity.” And honestly, I think that’s a blessing, seeing so much interest in health and well-being.
I remember the days when we had to preach that prevention was a good thing (makes me feel old). Now, running, lifting, tracking biomarkers, and competing to master your health is the cool thing to do. This is a cultural revolution, and I’m grateful to witness it in my lifetime.
In this week newsletter:
Inside Longevity Docs: Meet the Peptides Masters speaking at the Mastermind
Buzz in the Chat: Longevity Vacations • CGMs comparaison
Cover Story: GPs Are Facing Extinction
Research Radar: Lithium deficiency and the onset of Alzheimer’s disease • Statins and Their Effect on Hearing • Effect of HEPA Filtration Air Purifiers on Blood Pressure
Longevity Intelligence: La Mer Partners With The Salk Institute on Healthy Aging Fellowship • Oneskin Raises $20 Million
Longevity in the News: How to Live Forever and Get Rich Doing It • Longevity Firms Push Montana to Become Hub for Biohacking • GLP-1 weight-loss pills are coming.
Healthy Sunday!
Meet the Docs Speaking at the Peptides Mastermind
Most physicians have heard of peptides, often from two extremes:
Conservative skepticism, where evidence is seen as limited or anecdotal.
The wild west, with social media influencers and online platforms selling unregulated “research peptides” directly to consumers.
For practicing doctors, this creates a daily gap:
Between what patients are asking for and what’s taught in formal training.
Between cutting-edge science and safe, evidence-based protocols.
That’s why we’re bringing together the physicians who study, research, prescribe, and teach about peptides, so you can learn directly from the best how peptides can transform your practice, improve patient outcomes, and keep you at the forefront of modern medicine.
Become Peptides Smart.
Join 100+ physicians at the first-ever Peptides Mastermind
📍 New York City | October 4, 2025 | Convene 101 Park
👥 In-person seats are highly limited to preserve depth, exclusivity, and real connection.
I have a few patients who have asked: Does anyone recommend a clinic or a wellness center one can visit for a long weekend vacation? Can get MRI, labs, etc? In the US and international?
Sha Wellness
Zem Altea, Very close to Sha Wellness in Altea, Spain
Clinique La Prairie
Minus the total body MRI (which has not achieved adequate evidence) and focused on protocols based on over 100 published peer review papers, consider the Pritikin Longevity (aka Wellness) Center - but minimum one week for evidence based critical mass of any odds of real impact, two weeks even better - the education is as important as the medical visits and testing.
I haven’t been there since 2008 so I cannot vouch for the current staff but as far as a model that is now 50 years in evolution, it has been well vetted, thought focused on a level of proven evidence that some people wish to take the chance to push beyond. It’s a personal choice.
Hear Le Prairie has upped its game. But can’t imagine better than Lanserhof for high end high tech medical spa. But need 7 days. For long weekend, MA Canyon Ranch: could also stay there and go down the street to UltraWellness. But glad to hear above that some of our members offer this 3-4 day service now !
Curious to find out what Le Praire cellular treatment is. Does anybody know?
Which CGM do people like best? Affordable, accurate? For patients whose don’t meet requirements for coverage
I’ve used dexcom 4or 5. Generally works well, sensor lasts 10 days. In about 20% of patients the numbers don’t correlate well with lab values
I used Abbott lingo for about six months and then switched to Dexcom Stelo since it integrates with Oura ring. Lingo seemed more accurate. After switching to Stelo my numbers were consistently 20 points higher. I confirmed this with glucometer. I plan to try Stelo in different locations on the back of the arm. It may be related to not enough subcutaneous fat in certain areas.
Lingo hands down. You can now integrate into Apple health as well
I still think Abbott Free Style G3 is good, accurate and discrete.
In the UK I use Dexcom One+ with our clients on our metabolic reset programme.
Get 40 days worth of monitoring for £136. They have a half decent clinician dashboard to remotely track readings and analyse.
Although I haven’t played around with many others so would be interesting to hear others experiences…
I have had same experience with Stelo. Glucose measured high compared to glucometer and free style. Wore both at the same time! I do like that it integrates with Oura, but I don't like that you can't do a spot check on your glucose with your phone like FreeStyle Libre. In general, the free style Libre has been most accurate, and I can really hone in on the glucose better. With good rx, it's about 99 for 2, so a little pricer than Stelo, but lots of people's insurance covers.
Just had a patient tell me her health coach started her on different peptides. How do health coaches get to distribute peptides??
Because they have nothing to lose and everything to gain. Think about; no Medmal coverage. No medical license. Close up their LLC and walk away.
Exactly and because they’re not “medicines” they are not prescribing to treat anything
Yup 👍🏾 but we have to be careful how we position that because everything we do is in the practice of medicine. Sad state of affairs. Peptide challenges are worse than the stem cell challenges imo at this point
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Lithium deficiency and the onset of Alzheimer’s disease
Endogenous lithium appears to play a protective role in brain aging, with its depletion emerging as an early event in Alzheimer’s disease. In both humans and mice, reduced brain lithium—worsened in Alzheimer’s by amyloid sequestration—was linked to increased amyloid-β and phospho-tau accumulation, neuroinflammation, loss of synapses and myelin, and accelerated cognitive decline. Restoring lithium levels, particularly with amyloid-resistant lithium orotate, prevented these pathological changes and preserved memory, highlighting lithium homeostasis as a potential early intervention target for Alzheimer’s prevention and treatment. Nature
Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation
In the present study, we comprehensively analyzed the NAD+ synthesis pathways of orally and intravenously administered NMN and NR, demonstrating that most of NMN and NR were direct precursors of NAD+. Science Advances
Statins and Their Effect on Hearing: An All of Us Database Study
In this study, the All of Us database was used to investigate the relationship between statins and hearing loss/tinnitus. Results indicate a potential ototoxic association of statins on hearing and tinnitus. Annals of Otology, Rhinology & Laryngology
Effect of HEPA Filtration Air Purifiers on Blood Pressure: A Pragmatic Randomized Crossover Trial
The use of in-home HEPA air purifiers resulted in clinically important reductions in SBP for people with elevated SBP in environments with relatively low PM2.5 concentrations. JACC
Every week, I track the biggest moves in longevity: new funding rounds, partnerships, product launches, and key hires.
La Mer Partners With The Salk Institute on Healthy Aging Fellowship
La Mer has inked a first-of-its-kind partnership. The luxury skin care brand has partnered with The Salk Institute in San Diego on a three-year fellowship. Called the La Mer Healthy Aging Fellowship, the postdoctoral research program will focus on cell mitochondria and aging, and has been awarded to Ankita Chadda. SALK
Skin longevity firm Oneskin Announces $20 Million Investment From Prelude Growth Partners
Oneskin, the longevity-focussed skincare brand based in California, has secured a $20 million investment from growth equity firm Prelude Growth Partners, the company announced on Wednesday. Prelude Growth Partners’ investment buys out a former investor and will not dilute any other shareholders’ equity.
Every week, I comb through the mainstream headlines, handpick the most relevant longevity stories.
How to Live Forever and Get Rich Doing It
As researchers work to make death optional, investors see a chance for huge returns. But has the human body already reached its limits? The New Yorker
Longevity Firms Push Montana to Become Hub for Biohacking, Experimental Treatments
Montana is well known for luring visitors with outdoor activities such as fly fishing and hiking. Now, longevity companies are exploring investments in the state in a moonshot bid to make it a medical tourism hub. WSJ
The dangerously blurry line between wellness and medical tech
Whoop’s FDA notice is a reminder that it’s harder to tell what’s a medical feature and what’s “just for fun.” The Verge
GLP-1 weight-loss pills are coming. So are doubts about their potency.
Eli Lilly plans to seek regulatory approval for its experimental pill by the end of the year based on data that fell short of investor hopes. Washington Post
Longevity Conferences Calendar
ARDD: Copenhagen, August 25-29
Nubioage Clinical Longevity Summit: West Palm Beach, September 12-13, 2025
Longevity Investors Conference: Gstaad, Switzerland, September 22-25
Longevity Docs Peptides Mastermind: New York, October 4
Health Optimization Medicine Symposium: Boulder, October 17-18
Zenos Health Summit: Riyadh, October 23-25, 2025
Longevity Clinic Roundtable: Novato, December 6-8, 2025
A4M: Las Vegas, December 12-13
Longevity Docs Cannes: June 10-11, 2026
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.