Peptides Mastermind • Longevity Tourism • Longevity Regulations • Montana as a Longevity Hub?
Issue 52: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
I’m writing to you from Monaco, a country with the world’s highest life expectancy—an astonishing 89.8 years at birth in 2024 (86.0 for men, 93.7 for women). Of course, part of this is influenced by the social determinants of health and the unique selection of its population.
But it made me pause. Most countries topping the life expectancy charts don’t have ultra-advanced longevity technologies or cutting-edge clinics. Their secret isn’t in biohacking stacks or futuristic interventions, it’s in something else entirely.
Food for thought as we design the next era of longevity tourism: what can we learn from them, and what should we build on?
The Cannes recap video is out and watching it makes me realize how much I already miss this extraordinary tribe of doctors shaping the future of longevity medicine. Take a moment to relive what happened last week on the French Riviera.
In this newsletter, we dive into:
- The upcoming Peptides Mastermind in NYC
- Why Longevity Tourism will replacing medical and wellness tourism
- The latest on Longevity Regulations and what they mean for your practice.
The momentum we’re building is just the beginning.
Have an amazing week!
Peptides Mastermind – October 4, 2025 | NYC
This fall, an elite circle of forward-thinking physicians will gather in New York City for a full-day immersion into one of longevity medicine’s most discussed and most comple tools: peptides.
It’s a physician-only mastermind to help you master peptide-based therapies.
5 Reasons Every Physician Should Join
✅ 1. Lead the peptide revolution: GLP-1 RAs have made headlines and patients are self-prescribing online. It’s time for physicians to reclaim the narrative with evidence-based, ethical practices.
✅ 2. Decode complex regulations: Gain crystal-clear guidance on evolving rules and compliance to protect your practice and patients.
✅ 3. Master advanced protocols: Learn stacking strategies, breakthrough applications, and real-world outcomes from leading experts in the field.
✅ 4. Solve sourcing & quality challenges: Cut through the noise and secure high-quality compounds in today’s fragmented landscape.
✅ 5. Join a physician-only research network: Step into the trusted community and gain access to IRB-backed research collaborations led by physicians.
Curriculum
🔬 Clinical Excellence
Dive into mechanisms of action and advanced protocols
Explore stacking strategies and optimize in-practice outcomes
Hear real-world case studies from pioneering physicians
📈 Practice Growth
Navigate regulatory changes with confidence
Master sourcing, pricing models, and scalable program design
Position your clinic as a leader in peptide therapy
👋 Exclusive Networking & Experiences Adds-on
The night before: Private networking Mocktails
The evening of the event: Exclusive dinner at Zuma
📍 New York City | October 4, 2025 | Convene 101 Park
👥 In-person seats are highly limited to preserve depth, exclusivity, and real connection.
Attend the Longevity Docs Peptides Mastermind from Anywhere
Why Longevity Tourism Is Replacing Medical Tourism and Wellness Retreats
For decades, medical tourism was about fixing what’s broken: knees in Thailand, hair in Turkey. Wellness retreats offered temporary escape: green juice in Bali, colonics in Costa Rica. Both promised quick fixes and return to the same habits that made you leave in the first place.
But in 2025, something seismic is happening.
A new paradigm is emerging. One that doesn’t just treat symptoms or offer a week of relaxation. It’s designed to reprogram how we live and age.
Welcome to Longevity Tourism.
They want transformation that sticks.
Today’s high-functioning leaders, entrepreneurs, and creators aren’t flying across the world for a week of spa treatments and biohacks. They want transformation that sticks.
They want to understand their biomarkers, optimize their data, and build habits that compound over years not just few days.
The difference?
- Traditional wellness makes you feel better for a season.
- Longevity tourism could rewire your mindset
This isn’t a retreat. It’s a training camp for the future self you want to become.
What Longevity Tourism Experience Should Looks Like
In this model, guests are no longer passive patients or pampered spa-goers. They become active participants: learning, connecting, measuring, and transforming.
Learn: Workshops on cellular resilience, metabolic flexibility, and hormesis—led by world-class physicians, not yoga instructors.
Measure: Biomarker tracking, digital twins, and evidence-based protocols you can quantify and sustain at home.
Connect: Small, curated communities fostering peer learning and accountability long after the trip ends.
This is longevity tourism. For the smart traveler, optimizing your longevity is the new status symbol, outshining even the most opulent palace.
What It Means for Clinics & Doctors
The opportunity is clear:
Go beyond testing. Start delivering transformation.
Become guides who train bodies and minds not just treat symptoms.
Partner with luxury resorts to deliver physician-led longevity programs.
The future belongs to doctors who can navigate this convergence of medicine, technology, and hospitality. Those who don’t will be bypassed by consumers buying online biohacks with zero medical oversight.
What It Means for Hotels & Resorts
Detox menus and spa packages won’t cut it anymore. Guests are asking for:
Physician-backed, evidence-based transformation programs.
Learning ecosystems combining science, ancient wisdom, and community.
A new definition of luxury where longevity is the true marker of status.
Hotels that adapt now will lead a category projected to outpace both wellness and medical tourism combined.
Longevity Tourism Is Already Here
Medical tourism treated problems. Wellness retreats offered temporary relief. Longevity tourism builds systems for decades of vitality.
The question isn’t if it will replace traditional wellness travel.
It’s how quickly physicians and hospitality leaders will rise to lead it.
Peptides: Oral vs. Injectable, Regulation, and the Future
This week’s WhatsApp chat lit up with one of the most practical and provocative discussions yet. Over 20 physicians weighed in on the shifting peptide landscape—sharing insights, frustrations, and strategies as regulatory pressures mount.
The Debate: Oral BPC-157 vs. injectable formulations. Some reported limited success with oral for orthobiologic recovery, while others noted its effectiveness in gut health protocols post-SIBO/SIFO eradication.
The Regulatory Storm: One physician cautioned, “You can’t do research with an FDA non-approved product unless you’re a named investigator.” Another highlighted work with a new wholesale peptide company offering pharmaceutical-grade oral and IM options complete with a $125K insurance plan for patient protection.
Key Moves:
Several doctors shared trusted sources for retatrutide as compounded pharmacies pull back.
One physician flagged an upcoming IOF talk on peptide regulations later this month.
Multiple requests came in for supplier connections to meet high-volume needs.
As peptide access shrinks and FDA scrutiny rises, the group explored whether research-grade peptides are still viable or if pharma-backed approvals are the only sustainable path forward.
Why it matters
Peptides sit at the cutting edge of longevity medicine but they’re becoming a regulatory minefield. This conversation underscores a critical pivot:
Secure trusted suppliers.
Prepare for possible shifts toward pharma-dominated peptide markets.
Consider legal safeguards for your practice.
Want to be part of the WhatsApp group?
Join 400+ Longevity Docs exchanging protocols, insights, and clinical breakthroughs in real time.
Ageing is linked to inflammation — but only in the industrialized world
Inflammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations. Nature Aging
Skin health and biological aging
We provide a review of the interactions between skin exposure, aging hallmarks in the skin and associated systemic changes, and their implications in treatment and disease. We also discuss key questions that need to be addressed to maintain skin and overall health, highlighting the need for the development of precise biomarkers and advanced skin models. Nature Aging
Telomere Length and Biological Aging: The Role of Strength Training in 4814 US Men and Women
The findings showed that adults who strength trained regularly had significantly longer telomeres and therefore less biological aging than adults who did not strength train, even after taking into account many factors, including their age, sex, race, income, household size, smoking, body size, and participation in physical activities other than strength training. Biology
Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A meta-analysis of 23 trials found no solid clinical evidence that collagen supplements improve skin hydration, elasticity, or wrinkles, with positive effects seen only in low-quality, industry-funded studies. The American Journal of Medicine
Circulate Health Raises $12M to Scale Plasma Exchange
Circulate Health (co-founded by Drs. Brad Younggren and Eric Verdin) has closed a $12 million seed round from Khosla Ventures, Seaside Ventures, and CSC Ventures.
They’re building a network of over 50 clinics (currently at 24 across 8 states), offering therapeutic plasma exchange (TPE).
Montana Emerges as ‘Hub’ for Experimental Medical Treatments
Montana has passed a groundbreaking bill allowing clinics to offer experimental medical treatments that have only cleared Phase I safety trials, bypassing traditional FDA approval. Backed by longevity advocates, the law creates a licensing system for “experimental treatment centers” and protects prescribing physicians from disciplinary action. Supporters argue it empowers individuals with medical autonomy and could make Montana a hub for medical tourism. Critics warn it risks patient safety, as Phase I trials don’t prove efficacy and rarely reveal rare side effects. Several clinics, including those abroad, are already planning to set up operations under this new framework. MIT Review
Longevity Advocate Jim O’Neill Sworn in as Deputy Secretary of Health and Human Services
Jim O’Neill, former CEO of SENS Research Foundation, has been appointed deputy secretary of HHS under RFK Jr. Seen by longevity advocates as a powerful insider pushing for aging research, his voice could influence funding and regulatory flexibility for lifespan-extension programs. MIT Review
Longevity Conferences Calendar
ARDD: Coppenhagen, August 25-29
Longevity Docs Peptides Mastermind: New York, October 4
Zenos Health Summit: Riyadh, October 23-25, 2025
Longevity Clinic Roundtable: Novato, December 6-8, 2025
A4M: Las Vegas, December 12-13
Longevity Docs Cannes: June 10-11, 2026
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
Subscribe to the Longevity Docs Newsletter
Stay connected with the backstage of the Longevity Docs community, a network of over 400 physicians spanning 50 countries, united in our mission to democratize longevity medicine. Explore the latest in evidence-based longevity care, gain exclusive access to physician insights, and join us in shaping the future of this transformative field.
Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.
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