One-year, 50 countries • Repurposed Drugs for Longevity • Personal Branding for Docs • Neko's $250 Check-up
Your sneak peek into the world of Longevity Docs.
Hey Docs,
Exactly one year ago, I launched the Longevity Docs platform, and I’m blown away by how far we’ve come. I’m so grateful for this amazing community of forward-thinking physicians working together to advance Longevity Medicine. It feels like being back in med school - but this time, we’re from different specialties, countries, and backgrounds, learning and growing together.
In just 12 months, here’s what we’ve built together:
🩺 417+ doctors applying to join
🌍 50 countries represented
💬 ~250 messages exchanged weekly in our chat
📬 34 newsletters (I missed a few Sundays, but we’re catching up!)
📩 1,200+ newsletter subscribers
📍 6 in-person meetups connecting our docs
🤝 2 Mastermind events on Longevity Medicine
🎤 50+ world-class speakers sharing cutting-edge insights
📱 1 app launched to connect experts globally
🗝️ 1 private members club shaping the future of longevity medicine
What’s Next?
Hormones Mastermind (3/29, NYC): A one-day intensive featuring world-renowned experts.
Cannes Longevity Docs Summit (6/24-26, Cannes, France): Our largest event yet, blending innovation, education, and networking.
Longevity Docs Magazine Launch: A new platform to amplify your voices and highlight advancements in our field.
The Longevity Medicine Revolution is well underway, and this is only the beginning. Thank you for being part of this journey. Together, we’re shaping the future of health.
Happy Sunday,
David
#LongevityMindset
Longevity Docs Club Forum
The Forum iss an exclusive, invite-only event for private members of Longevity Docs Club.
The Power of Personal Branding
As physicians, effective communication is a cornerstone of our profession—whether it’s explaining complex science to patients, delivering difficult news to families, or discussing potential side effects of treatment. Yet, public speaking and digital content creation are rarely taught in medical school. In today’s digital age, your social media profiles are more than just a place to post updates—they're your modern-day website, marketing platform, and even your Yelp review. Patients increasingly select physicians based not only on expertise but also on their digital presence.
In our recent Longevity Docs Club forum, we explored the importance of personal branding for physicians, especially in a field like longevity medicine, where non-medical influencers often dominate due to their abundant resources (time, brand partnerships, and media skills). To guide us, we were joined by a former marketing leader from Oura and Red Bull, who shared actionable insights tailored to healthcare professionals.
Key Takeaways
A Strong Digital Presence is Non-Negotiable
Physicians looking to expand their reach, establish credibility, and grow their personal brand must invest in their online presence. Social media, blogs, and professional platforms are essential tools for standing out in a competitive market.Start Today: Even Small Steps Matter
Building a loyal audience, like those of Peter Attia or Andrew Huberman, takes time and consistency. Begin by posting today to establish a habit. (Think of it as "One post a day keeps obscurity away!")Consistency and Authenticity Win
To succeed, be genuine in your content and consistent in your posting. Don’t take on projects you can’t sustain (like starting a podcast) unless you’re ready to commit for at least three years. Longevity is as much about your brand as it is about your patients.
Next Steps: If you haven’t already, take the first step by improving your bio, posting educational content, or sharing insights from your practice. Remember, your expertise deserves the spotlight and the right digital presence can amplify your impact.
Which of these drugs have you tried or researched for longevity?
Buzz:
The chat heated up over ranking repurposed longevity drugs, with Docs debating which compounds show the most promise:
Rapamycin (Sirolimus): A key mTOR inhibitor with potential anti-aging benefits.
Metformin: The popular diabetes drug often explored for its effects on metabolic health and aging.
Selegiline (Deprenyl): A monoamine oxidase inhibitor thought to support brain health and neuroprotection.
Low-Dose Naltrexone (LDN): Known for its potential to modulate inflammation and immune response.
SGLT2 Inhibitors (e.g., Empagliflozin): Originally for diabetes, now being studied for heart and kidney health.
Low-Dose GLP-1 Agonists (e.g., Semaglutide): Notable for weight loss and metabolic regulation.
Acarbose: Gaining interest for its impact on gut microbiota and metabolic health.
Deferoxamine (Iron Chelator): Potentially beneficial for reducing oxidative stress by managing iron overload.
Colchicine: An anti-inflammatory often studied for cardiovascular health.
PDE5 Inhibitors (e.g., Sildenafil): Studied for vascular health and nitric oxide regulation.
Enclomiphene: A newer option to address testosterone regulation.
Low-Dose Statins: For their role in cardiovascular risk reduction and inflammation control.
ACE Inhibitors or ARBs: Key in blood pressure management and organ protection.
Low-Dose Aspirin: Long debated for its potential in reducing cardiovascular events.
Selbex (Teprenone / GGA): Investigated for gastric protection and cellular stress responses.
Key Takeaways:
Rapamycin, LDN, and GLP-1 Agonists are ranked among the most promising longevity drugs.
Acarbose’s impact on gut health and metabolic pathways is being closely examined.
The need for better clinical outcome data remains a challenge for repurposed drugs
Plasmapheresis Research & Spike Protein Removal
Buzz:
New insights emerged on plasmapheresis as a tool for filtering spike protein and toxic peptides. Docs shared findings from an upcoming publication demonstrating that STRATOS EBOO, a Japan-made filtration system, effectively captures spike proteins at 1/5 the cost of standard plasmapheresis. The discussion also touched on the need to eliminate senescent cells harboring mRNA to prevent continuous spike production.
Key Takeaways:
STRATOS EBOO may offer a cost-effective alternative for filtering spike protein and toxic peptides.
Eliminating senescent cells is crucial to stopping persistent spike protein generation.
Maintenance treatments post-plasmapheresis may help sustain long-term benefits.
Methylation Clocks & Biomarker Accuracy
Buzz:
Docs shared a critical study highlighting the limitations of DNA methylation clocks, pointing out their reliance on outdated aging models. The conversation revolved around the need for more robust biological age markers and how AI could refine the accuracy of longevity diagnostics.
Key Takeaways:
Current methylation clocks may be flawed, using outdated elastic regression models.
AI-driven biological age assessments could provide more reliable insights.
Physicians are looking for more actionable and clinically relevant biomarkers for longevity.
Future of Retatrutide: The Next Big Longevity Drug?
Buzz:
The chat was buzzing about Retatrutide, the next-generation GLP-1/GIP/Glucagon triple agonist, which some believe could outperform current GLP-1 drugs like Semaglutide and Tirzepatide. Early experiences using it for non-weight loss applications suggest enhanced metabolic flexibility, muscle preservation, and potential longevity benefits. The group debated whether Retatrutide’s triple-action mechanism might be the most profound chronic disease intervention yet or if it carries greater risks due to its potency.
Key Takeaways:
Retatrutide is showing promise beyond weight loss, with potential applications in longevity, metabolic health, and muscle preservation.
Its triple agonist mechanism may be more effective than current GLP-1 drugs but could also carry unique risks.
Close monitoring of long-term safety data and regulatory hurdles will determine its future adoption.
Welcoming New Members
I’d like to officially welcome our new Docs: Stephen Sanders, Kay Durairaj, Robert Todd Hurst, Gurmeet Sonibhalla, Fernando Dantas, Priyanka Mohol, William LaValley, Ryan Greene, Mohamad Ali
What’s Hot? by Dr. Anant Vinjamoori
Retail Clinic: Is Neko Health Really the Future of Health
Neko Health's body scans have been getting a lot of attention lately. But are they really the future of health?
Effortless, sleek, and surprisingly affordable, they package efficiency into an experience that feels like stepping into the future.
However, the data they’re capturing, while abundant, isn’t exactly cutting-edge. It’s mostly vital signs, anthropmetrics, and routine lab work—things we’ve been measuring for decades.
The camera-driven skin analysis might feel high-tech, but it’s ultimately replicating what a trained clinician can do. The blood tests? Point-of-care staples, not breakthroughs.
No doubt, making these basic markers more accessible to more people, on a more frequent basis, will be valuable on some level.
And it's definitely worth celebrating the new standard they have set for accessibility and efficiency, showing what’s possible when healthcare design is approached with an eye for user experience.
However, the real frontiers of health lie deeper—in cellular biology, system-level dynamics, and biomarkers that illuminate the unseen layers of disease and aging.
Neko has optimized the old, not redefined the new.
The true revolution in health will come when we look beyond surface-level measurements and unlock the complexity of human biology.
DNA Methylation Clocks & Biomarker Accuracy
New findings suggest that commonly used DNA methylation clocks rely on outdated regression models, potentially leading to inaccurate biological age assessments.
Geroscience – Recommended by Elizabeth Yurth
Metformin vs. Acarbose for Longevity
Comparative study on the cardiovascular effects of Metformin and Acarbose in a Taiwan population cohort.
JCEM – Recommended by John Haughton
Ergothioneine and Healthspan Extension in Animals
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation.
Cell – Recommended by Giovanni Campanile
NAD World 3.0
The NAD World 3.0, is now proposed, featuring multi-layered feedback loops mediated by NMN and eNAMPT for mammalian aging and longevity control.
npj Aging – Recommended by Dr. Thomas Paloschi
Longevity Docs Events
Past
Longevity Docs Club Forum January
Coming Next
Longevity Docs Club Forum
📅 Date: February 28, 2025
📍 Location: Virtual
This event is reserved for private members of the Longevity Docs Club
Longevity Docs Hormones Mastermind
📅 Date: March 29, 2025
📍 Location: Convene 101 Park Ave, New York (In-person & Digital Access Available)
This one-day, 10-course curriculum features dozen world-renowned experts, offering an unique opportunity to elevate your expertise in hormonal health and longevity medicine.
Longevity Docs Cannes
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
Others Events
Global Healthspan Summit: Ryadh - February 4-5
Founders Longevity Forum - Singapore, February 27-28
Vitalist Bay - Berkeley, CA, Apr 4 - May 29
The Longevity Med Summit - Lisbon, May 6-8
Life Summit - Berlin, May 27-28
Scientists Discover Promising Molecule That Restores Cognitive Function in Early Alzheimer’s
Researchers have identified a molecule that shows potential in reversing cognitive decline in early-stage Alzheimer’s, opening new possibilities for neurodegenerative disease treatment.
Obesity drugs: huge study identifies new health risks
New research explores the potential benefits and risks of GLP-1 drugs like Semaglutide, raising questions about long-term effects on metabolism and joint health.
Nearly Half of Primary Care Doctors Are Now Hospital-Affiliated
A new report reveals that nearly half of primary care physicians are now affiliated with hospitals or health systems, signaling a shift away from independent practice and raising concerns about consolidation in healthcare.
At Longevity Docs, we offer two distinct membership to support doctors in longevity medicine:
Basic Membership
Become part of a global network of 300 longevity-focused physicians across 50 countries, access to our app, educational resources, and opportunities to attend exclusive events.
Private Club Membership
For those seeking a more immersive experience, the Private Club Membership offers all the benefits of Standard Membership, plus exclusive access to private events, monthly forums, deeper collaboration with experts, and early insights into cutting-edge longevity practices.
Eligibility: Open exclusively to medical doctors operating a healthcare practice or leading a business dedicated to longevity.
Every Doctor Should be a Longevity Doctor
As a heart surgeon, I was often the doctor you hoped never to need . If you were in my operating room it means prevention was no longer an option. My father, a physician specializing in Chinese medicine and acupuncture, taught me about preventive care very early on. At 21, in 2001, I launched a foundation focused on operating on children in Africa, India, Cambodia, and Haiti so they could live longer, healthier lives.
In 2020, everything changed. When my wife contracted COVID-19, I realized the future of medicine lies in prevention. This led me to found a digital clinic dedicated to combating preventable age-related diseases, immersing myself in longevity research and new tech.
However connecting with like-minded doctors was the hardest part. I started a WhatsApp group with a dozen doctors passionate about longevity. We shared publications, new tech tools, and discussed case studies. It quickly grew into something bigger, and I realized we lacked a structured platform to learn, exchange insights, and shape the future of evidence-based longevity medicine.
From this need, Longevity Docs was born. Today, we unite 300 physicians across 50 countries with a shared goal: to democratize longevity medicine. Imagine a world where physicians have access to evidence-based practices, collaborate with experts, and conduct research together - in real-time, anywhere in the world.
I firmly believe that a decentralized, collective intelligence of physicians is the key to extending human healthspan. Together, we can create a legacy where medicine helps people live better.
Dr. David Luu
Subscribe to the Longevity Docs Newsletter
Stay connected with the backstage of the Longevity Docs community, a network of over 300 physicians spanning 50 countries, united in our mission to democratize longevity medicine. Explore the latest in evidence-based longevity care, gain exclusive access to physician insights, and join us in shaping the future of this transformative field.
Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.