Memberships or Pay-Per-Visit? • Telomerase Talk • GHRH + GLP-1 Strategies • p-tau217 & Alzheimer
Your sneak peek into the world of Longevity Docs.
Hey Docs,
As I was landing in one of the world’s most dangerous airports, in a 40-year-old plane with minimal tech, I found myself watching the pilot closely. No fancy autopilot. No AI. Just skill, focus, and decades of experience.
It made me think about medicine.
Over the past 50 years, we’ve evolved a lot. But lately, there's been a real pull toward shiny object syndrome: chasing the newest drug, the latest tool, the trendiest protocol. And while innovation matters, many of these breakthroughs only apply to small percentage of what truly makes a difference.
As a physician, what actually moves the needle?
Your experience. Your skillset. Your patience to learn. Your humility to keep learning.
Landing that plane wasn’t about tech, it was about expertise. And what struck me most was seeing the pilot training the co-pilot mid-flight. Just like surgeons do. Just like we all should.
Training. Mentorship. Passion. Purpose. That’s what builds excellence.
This is the mindset we’re building at Longevity Docs, and I’m grateful for this community every day.
Let’s keep flying high, with both wisdom and heart.
In this week’s newsletter:
Culture: moving from pay-per-visit to membership model
Buzz in the Chat: GHRH and GLP1, TA65 and telemores
Science: Rapamycin Improves PROMs in Patients With ME/CFS in Early Trial
Happy Sunday!!!!
TA65 & telomeres
A lively debate unfolded on the clinical validity of telomere testing and the effectiveness of TA65.
Dr. JR shared compelling insights highlighting TA65’s role in improving T-cell function and reducing senescence markers.
Dr. FC backed long-term use of TA65 in her clinic, citing outcomes like reversal of skin aging and improved vision.
Dr. EY voiced skepticism, emphasizing the limitations of telomere testing (only leukocytes measured, high variability), and raised safety concerns based on mouse data linking TA65 to liver cancer.
Takeaway: While some clinicians report powerful anecdotal benefits, the science remains split. There's growing interest in alternative approaches like epitalon (peptide, telemorase activator) and senescence biomarkers for more precise applications.
GHRH peptides to manage muscle Loss on GLP-1s?
The group tackled the challenge of preserving muscle mass in patients using GLP-1s like Ozempic and tirzepatide.
Dr. JB shared a case of muscle loss, sparking protocols around combining GLP-1s with GHRH peptides (e.g., sermorelin, ipamorelin, tesamorelin).
Dr. CJ offered a deep dive into DEXA scan interpretation, stressing that most lean mass “losses” are shifts in water/glycogen, not true skeletal muscle.
Dr. ML added real-world N=1 data supporting ipamorelin + GLP-1 combo for fat loss with muscle preservation.
Takeaway: Individualized protocols: including peptide pairing, adequate protein intake, and tools like BIA/DEXA—are key. Special caution is advised in perimenopausal women due to fluid retention risks.
Private Club
Member Spotlight
Meet the Longevity Doctors Club members: physicians entrepreneurs building the future of longevity medicine one practice (or more) at the time.
Cynthia Keller, MD
Founder, Centered in Wellness
Dr. Cynthia Keller is a board-certified pediatrician with over 25 years of clinical experience and a deep commitment to transforming health at every stage of life. Early in her career, she recognized that conventional medicine alone wasn’t enough to help her patients thrive, so she set out to find a better way.
Her journey led her to pursue advanced training in Integrative Medicine and Anti-Aging & Regenerative Medicine, adding two board certifications to her credentials. In 2014, she founded Centered in Wellness, a concierge clinic in the Seattle area offering collaborative, multidisciplinary care for both children and adults. The clinic blends cutting-edge longevity and cellular medicine with compassionate, whole-family support, treating chronic illness and optimizing wellness with equal care.
Dr. Keller’s clinical interests include pediatric development, chronic immune dysregulation (including PANDAS), gut health, mold and toxin illness, and age-reversal strategies through peptide therapies and metabolic interventions. She is known for her practical and science-based approach to longevity, and for empowering families with education and tools to lead healthier lives.
In addition to her clinical work, Dr. Keller is a sought-after speaker and educator. She lectures nationally on topics such as cellular medicine, GI health, peptide therapeutics, and the clinical applications of longevity science. She serves on faculty at SSRP (Seeds Scientific Research & Performance), is an Elite Practitioner with Prodrome Sciences, a speaker for CALM (Clinical Application of Longevity Medicine), and a proud Club Member of Longevity Docs.
Dr. Keller brings together experience, empathy, and innovation - meeting each patient where they are, and walking with them toward lifelong vitality.
Connect with Dr. Cynthia Keller
Join the Longevity Docs Club
If you’re a physician starting or scaling your longevity practice highly vetted Longevity Docs Club is for you.
Join a community of like-minded physicians and gain access to resources on marketing, finance, strategy, and technology to support your independent practice
Applications now open for MD, DO, or MBBS - Limited memberships
A natural experiment on the effect of herpes zoster vaccination on dementia
Through the use of a unique natural experiment, this study provides evidence of a dementia-preventing or dementia-delaying effect from zoster vaccination that is less vulnerable to confounding and bias than the existing associational evidence.
Nature - Recommended by Dr. Steven Murphy
Rapamycin Improves PROMs in Patients With ME/CFS in Early Trial
A recent study on 40 ME/CFS patients showed that weekly rapamycin (up to 6 mg) significantly improved fatigue, sleep quality, and orthostatic intolerance over a 3-month period. These positive shifts in patient-reported outcomes (PROMs) support rapamycin’s potential role in managing ME/CFS, likely due to its mTOR inhibition and autophagy activation. More granular data and subgroup analyses are forthcoming, which could clarify responder profiles and optimize dosing strategies.
HCPLive - Recommended by Dr. Thomas Paloschi
Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform
A new multicenter study found that a fully automated blood test measuring plasma p-tau217 accurately detects Alzheimer’s disease pathology across both primary and secondary care settings. With up to 94% accuracy using a two-cutoff approach, the test performed well regardless of age, sex, or comorbidities, and offers a scalable, cost-effective alternative to more invasive diagnostics like cerebrospinal fluid testing or PET scans.
Nature - Recommended by Dr. Thomas Paloschi
Why Longevity Docs are shifting from pay-per-visit to membership-based models
Longevity medicine isn’t built for quick visits and transactional care. As more physicians move into prevention, performance, and personalized protocols, many are realizing that the traditional pay-per-visit model simply doesn't work.
What’s emerging instead is a membership-based model - designed for depth, not volume. Think concierge medicine 2.0 including testing, devices, and interventions.
Here’s why more longevity docs are making the shift.
5 advantages of the membership model:
Continuity of care for better outcomes: longevity-focused outcomes takes time. Memberships give you the space to track biomarkers, optimize protocols, and build meaningful change.
Predictable revenue & sustainable growth: recurring income creates financial stability and helps you invest in your clinic & team, cutting-edge technology, and your time, without chasing insurance reimbursements.
Higher engagement, better Adherence: patients who commit to a membership are more engaged. They follow through. They show up. That creates a compounding effect in their results.
Freedom to practice your way: no more squeezing insights into 20-minute slots. You get to design your ideal care experience: more in-depth lab reviews and personalized interventions.
Stronger relationships, less burnout: you serve fewer patients, but go deeper. That means more impact, more trust, and more energy left at the end of the day.
5 limitations of the membership model
It’s not a fit for everyone: some patients still expect one-off solutions. Others can’t afford or aren’t ready to commit to long-term care.
Operations are more complex: from onboarding and renewals to scheduling and communication, membership practices require tighter systems and trained teams.
Team alignment: if your staff isn’t trained in concierge care and membership mindset, patient experience suffers. Everyone has to be rowing in the same direction.
Need strong brand and marketing: this isn’t insurance-based volume. You’re building a brand, not just a clinic. That takes messaging, positioning, and clarity on your ideal patient.
Scaling can be complex: memberships don’t scale like visits. You need infrastructure: community platforms, CRM, automated touchpoints, and potentially a team to support retention.
My prediction
Access to good medicine is not equitable. It still depends on who you know, where you live, what you understand, and what resources you have. But that’s changing.
Patients are becoming more savvy. They’re no longer passive recipients of care. They’re active consumers of health, and they’re starting to behave more like members of a hospitality brand or country club than patients in a traditional system.
They’ll invest in what matters:
long-term health outcomes but not only
exceptional experience
personalized education
impeccable brand
like-minded community
and most of all: trust.
At Longevity Docs, we know that physicians who understand their unique skillsets, their audience, and their value - and who know how to communicate it with clarity -will be the ones who achieve both impact and freedom.
This isn’t just about medicine. It’s about building a movement rooted in integrity, connection, and purpose.
Want Better Health and Status? For $250,000, Longevity Clinics Promise Both
The health-conscious elite are flocking to high-end clinics in the hopes of getting ahead of the aging process. WSJ
As Next Health Eyes Expansion, It’s Also Pushing for a Healthcare Revolution
If Next Health has its way, people will soon be spending less time inside their primary care doctor’s offices – and they’ll be a lot healthier as a result. Athletech News
Longevity Docs Summit Cannes
This is not just another medical conference, this is the future of cutting-edge longevity medicine.
Join the world’s most visionary longevity physicians, scientists, and innovators for two days of breakthroughs, discoveries, and high-level networking under the French Riviera sun.
Summit. Awards & Black tie Gala. Expo.
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
🎟️ Registrations are now open: and spots are limited.
👉 Apply now before it sells out. The New Gods of Medicine will be in Cannes. Will you?
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Longevity Conferences Calendar
A4LI DC Summit: Washington DC - April 28-30
Vitalist Bay - Berkeley, CA, Apr 4 - May 29
The Longevity Med Summit - Lisbon, May 6-8
Life Summit - Berlin, May 27-28
Dublin Longevity Summit: Dublin, July 2–4
ARDD: Coppenhagen, August 25-29
At Longevity Docs, we offer two distinct membership to support doctors in longevity medicine:
Basic Membership
Become part of a global network of 300 longevity-focused physicians across 50 countries, access to our app, educational resources, and opportunities to attend exclusive events.
Private Club Membership
For those seeking a more immersive experience, the Private Club Membership offers all the benefits of Standard Membership, plus exclusive access to private events, monthly forums, deeper collaboration with experts, and early insights into cutting-edge longevity practices.
Eligibility: Open exclusively to medical doctors operating a healthcare practice or leading a business dedicated to longevity.
Every Doctor Should be a Longevity Doctor
As a heart surgeon, I was often the doctor you hoped never to need . If you were in my operating room it means prevention was no longer an option. My father, a physician specializing in Chinese medicine and acupuncture, taught me about preventive care very early on. At 21, in 2001, I launched a foundation focused on operating on children in Africa, India, Cambodia, and Haiti so they could live longer, healthier lives.
In 2020, everything changed. When my wife contracted COVID-19, I realized the future of medicine lies in prevention. This led me to found a digital clinic dedicated to combating preventable age-related diseases, immersing myself in longevity research and new tech.
However connecting with like-minded doctors was the hardest part. I started a WhatsApp group with a dozen doctors passionate about longevity. We shared publications, new tech tools, and discussed case studies. It quickly grew into something bigger, and I realized we lacked a structured platform to learn, exchange insights, and shape the future of evidence-based longevity medicine.
From this need, Longevity Docs was born. Today, we unite 400+ physicians across 50 countries with a shared goal: to democratize longevity medicine. Imagine a world where physicians have access to evidence-based practices, collaborate with experts, and conduct research together - in real-time, anywhere in the world.
I firmly believe that a decentralized, collective intelligence of physicians is the key to extending human healthspan. Together, we can create a legacy where medicine helps people live better.
Dr. David Luu
Subscribe to the Longevity Docs Newsletter
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.