Longevity Medicine in Davos • Longevity Docs App Launch • Longevity & AI
Your sneak peek into the world of Longevity Docs.
Hey Docs,
I just returned from Davos, where the World Economic Forum gathered leaders from around the globe. At CNBC's Centaurs AI Summit, I had the opportunity to discuss the importance of longevity medicine and the transformative role of AI in our society. As physicians, these are our daily discussions, yet there's a vast audience that still needs to understand the profound impact of longevity medicine.
On a practical note, our Longevity Docs App is now live, with 200 top physicians already on board. This platform is designed to connect longevity doctors globally, provide access to evidence-based education, and accelerate collaborative research. Imagine a new social platform for longevity doctors.
Looking ahead, AI is poised to revolutionize our field faster than we might anticipate. Innovations such as AI models capable of reprogramming cells and "operators" that assist in multitasking for doctors are on the horizon. The landscape is evolving rapidly, and physicians who don't adapt may find themselves left behind.
The Longevity Medicine revolution has started
Happy Sunday!
David
The Longevity Docs App is Live
The Longevity Docs App is here, and 200 top physicians have already joined! Designed for leaders in longevity medicine, it connects you to an exclusive community of experts, cutting-edge insights, and premium learning tools. Features include live chat for real-time networking, a global directory for referrals, exclusive event access, expert-curated masterclasses, and perks like member discounts.
GLP-1 and Joint Pain:
Buzz:
Controversy around whether GLP-1 agonists worsen osteoarthritis (OA) and joint pain. Mixed evidence shared, with some studies suggesting a worsening effect, while others highlight analgesic properties.
Mechanism of action and duration of treatment effects discussed, with questions on weight loss impact and dosage.
Positive comments on GLP-1 benefits, with skepticism about negative findings.
Key Takeaways:
Debate reflects unsettled science, with more data needed on arthritis impact.
Shared studies and anecdotal patient responses highlighted research gaps.
Compounded Medications (Tirzepatide, Semaglutide):
Buzz:
Court orders stopping compounding pharmacies from providing medications like Tirzepatide (503A/503B regulations).
Discussions on sourcing alternatives and adjusting treatment plans with Retatrutide and Ozempic.
Concerns about rising costs and logistics with single pharmacy distribution (e.g., Lilly’s exclusivity).
Key Takeaways:
Shifts in compounding regulations are disrupting access, creating challenges for doctors and patients.
Focus on affordable alternatives and optimizing supply chains.
Methylene Blue (IV vs. Oral):
Buzz:
IV Methylene Blue discussed as a last-resort therapy for septic shock and its potential benefits in acute neurological conditions (e.g., TBI, stroke).
Preference for low-dosing strategies, gradually escalating as needed.
Shared protocols for septic shock and neurological use, emphasizing careful monitoring.
Key Takeaways:
IV Methylene Blue considered powerful but requires expertise for safe application.
Participants noted differences in patient tolerance between oral and IV forms.
Hyperbaric Oxygen Therapy (HBOT) and Hypoxia:
Buzz:
Contrasts between continuous hypoxia (negative) and intermittent hypoxia (positive).
Benefits of high-altitude living and implications for HBOT highlighted.
Articles shared discussing the hyperoxic-hypoxic paradox and hypoxia’s role in chronic disease management.
Key Takeaways:
Group interest in leveraging intermittent hypoxia and HBOT for longevity and disease prevention.
A need for clearer evidence and protocols for HBOT in specific conditions.
TGF-b1 Biomarker
Buzz:
Alarm over lab reference range changes post-pandemic, increasing the "normal" TGF-b1 threshold.
Implications for misdiagnosis and overlooked inflammation discussed.
Calls for collaboration on tracking TGF-b1 and related biomarkers like beta-amyloid and p-tau ratios.
Key Takeaways:
Concerns about shifting "normal" ranges masking significant health issues.
Interest in using biomarkers for personalized treatment and interventions like TPE and rapamycin.
Welcoming New Members
I’d like to officially welcome our new Docs: Anna Erat, Patrick Sewell, Christin Glorioso, Louis dePalo, Anna Emanuel, Sam Botchey, Lilis Haryati, Nathalie Elm, Eric Fete.
Longevity Docs Celebration
Dr. Jesse Greer’s Preamble partners with Village Health Clubs To Launch Next-Gen Healthspan Healthcare Program
“The Scottsdale community is full of individuals dedicated to achieving a healthier, longer life. Preamble supports this goal with a health approach centered on longevity-focused medicine that emphasizes preventative care, performance optimization and comprehensive health analysis rather than solely focusing on treatment,” said Dr. Jesse Greer, founder of Preamble. “We’re thrilled to collaborate with The Village, a cornerstone of health and wellness in the community, to bring this innovative program to their fitness-forward clientele.”
What’s Hot by Dr. Luu
AI and Longevity: What It Means for Physicians
OpenAI has partnered with Retro Biosciences, a biotech startup aiming to extend healthy human lifespan by 10 years, to develop GPT-4b micro, an AI model designed for biological research. Unlike traditional models like Google’s AlphaFold, GPT-4b micro focuses on re-engineering proteins, such as Yamanaka factors, which can turn human skin cells into youthful stem cells. This could pave the way for regenerative medicine, organ repair, and age-related therapies.
For clinical practice today, nothing changes - but tomorrow, everything might. With AI analyzing labs, validating interventions, and optimizing drugs and supplements, the physician’s role will evolve. Instead of spending time on manual diagnostics, doctors may focus on interpreting insights, personalizing care, and building patient trust.
Soon "Longevity Agents" will manage diagnostics and treatment plans for doctors but human oversight will remain critical to validate AI outputs and integrate them into holistic care. Physicians will lead by combining technology with empathy, ensuring longevity solutions improve not just lifespan but quality of life.
The future of longevity care is coming fast. Are physicians ready to lead it?
GLP-1 Agonists and Joint Pain
Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis.
Nature Article - Recommended by Sanjay Raisoni
The Hyperoxic-Hypoxic Paradox
This article reviews oxygen physiology, the main cellular processes triggered by hypoxia, and the cascade of events triggered by the HHP.
Biomolecules - Recommended by Scott Sherr
Assessing the reliability of coronary artery calcium score in symptomatic patients: challenging the 'power of zero'
The study unveiled a significant number of symptomatic patients with a CAC score of zero who actually had atherosclerotic plaques. This finding challenges the notion of the infallible "power of zero" in symptomatic patients.
European Journal of Preventive Cardiology - Recommended by Giovanni Campanile
The Physiology of Hunger
This review describes basic and translational research on the complex physiological processes of hunger, which regulate feeding habits and are influenced by socioeconomic, cultural, and behavioral factors.
NEJM - Recommended by Tracy Gapin
Longevity Docs Events
Davos - CNBC’s Centaur’s AI Summit
At this year’s World Economic Forum in Davos, I had the privilege of curating and moderating a longevity-focused panel “Longevity at the Age of AI” hosted by CNBC’s Centaur AI Summit. The panel featured visionary unicorns founders like Giorgos Tsetis (Nutrafol), Saeju Jeong (Noom), and Michele Longmire (Medable), exploring the transformative impact of AI on health, wellness, and longevity.
A highlight of the event was a fireside chat with Naveen Jain (Viome), moderated by Olivier Oullier. Together, we discussed how AI-powered platforms are reshaping clinical practice, empowering physicians to deliver hyper-personalized, preventative care.
Longevity medicine is now a topic of global discussion, highlighting the need for more research, evidence, and data to make it a reality. The summit emphasized that while AI provides valuable insights, it's the expertise of physicians that ensures these advancements are applied effectively and ethically.
Davos - Longevity Investors Lunch
At the recent Longevity Investors Lunch in Davos, I had the opportunity to discuss how decentralized science (DeSci) can accelerate breakthroughs in longevity. I was joined by Brian K. Magierski and Dr. Emil Kendziorra, with the event hosted by Dr. Tobias Reichmuth and Marc P. Bernegger, and featuring a keynote from Deepak Chopra.
Coming Next
Longevity Docs Club Forum
📅 Date: January 31, 2025
📍 Location: Virtual
This event is reserved for private members of the Longevity Docs Club
Longevity Docs Hormones Mastermind
📅 Date: March 29, 2025
📍 Location: Convene 101 Park Ave, New York (In-person & Digital Access Available)
This one-day, 10-course curriculum features dozen world-renowned experts, offering an unique opportunity to elevate your expertise in hormonal health and longevity medicine.
Longevity Docs Cannes
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
Others Events
Founders Longevity Forum - Singapore, February 27-28, 2025
Vitalist Bay - Berkeley, CA, Apr 4 - May 29, 2025
The Longevity Med Summit - Lisbon, May 6-8, 2025
Life Summit - Berlin, May 27-28, 2025
OpenAI has created an AI model for longevity science
The company is making a foray into scientific discovery with an AI built to help manufacture stem cells.
Can a $20,000 Longevity Clinic Really Help You Live Longer?
People are paying thousands for exhaustive medical tests and treatments like plasma exchange and peptide therapy. How much does it benefit...
After an obesity stumble, BioAge reconnects with its longevity pipeline
The company is kicking off the year with a new Novartis partnership and renewed focus on metabolic aging targets.
Being in shape is better for longevity than being thin, new study shows
A comprehensive review found that being out of shape greatly increased the risk of dying prematurely — regardless of age or body mass index.
At Longevity Docs, we offer two distinct membership to support doctors in longevity medicine:
Basic Membership
Become part of a global network of 300 longevity-focused physicians across 50 countries, access to our app, educational resources, and opportunities to attend exclusive events.
Private Club Membership
For those seeking a more immersive experience, the Private Club Membership offers all the benefits of Standard Membership, plus exclusive access to private events, monthly forums, deeper collaboration with experts, and early insights into cutting-edge longevity practices.
Eligibility: Open exclusively to medical doctors operating a healthcare practice or leading a business dedicated to longevity.
Every Doctor Should be a Longevity Doctor
As a heart surgeon, I was often the doctor you hoped never to need . If you were in my operating room it means prevention was no longer an option. My father, a physician specializing in Chinese medicine and acupuncture, taught me about preventive care very early on. At 21, in 2001, I launched a foundation focused on operating on children in Africa, India, Cambodia, and Haiti so they could live longer, healthier lives.
In 2020, everything changed. When my wife contracted COVID-19, I realized the future of medicine lies in prevention. This led me to found a digital clinic dedicated to combating preventable age-related diseases, immersing myself in longevity research and new tech.
However connecting with like-minded doctors was the hardest part. I started a WhatsApp group with a dozen doctors passionate about longevity. We shared publications, new tech tools, and discussed case studies. It quickly grew into something bigger, and I realized we lacked a structured platform to learn, exchange insights, and shape the future of evidence-based longevity medicine.
From this need, Longevity Docs was born. Today, we unite 300 physicians across 50 countries with a shared goal: to democratize longevity medicine. Imagine a world where physicians have access to evidence-based practices, collaborate with experts, and conduct research together - in real-time, anywhere in the world.
I firmly believe that a decentralized, collective intelligence of physicians is the key to extending human healthspan. Together, we can create a legacy where medicine helps people live better.
Dr. David Luu
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.