Longevity Docs Podcast - Attia's Biograph Clinic - Fasting & Insulin Resistance - Estrogen & Clotting Risks
Your sneak peek into the world of Longevity Docs.
Hey Docs,
This week, I hosted an intimate longevity dinner with some of the leading minds in the space. I cooked crawfish with mango with yuzu/ponzu sauce, a burrata pesto salad and a Lamb à la Provençale with quinoa “couscous”.
A few behind-the-scenes moments from the night: because nourishing your community is just as important as nourishing your body. After all, strong relationships are a cornerstone of longevity.
In this week newsletter
Coming soon - the Longevity Docs Podcast: a deep dive into cutting-edge longevity medicine to inspire and empower doctors navigating the rapidly evolving field.
Buzz in the Chat: Does Fasting Cause Temporary Insulin Resistance? Hormone Therapy and Clotting Risks: Oral vs. Transdermal Estrogen
What’s Hot: Peter Attia officially enters the longevity clinic space with Biograph, emerging from stealth. What does this mean for Longevity Docs?
Happy Sunday!
David
#LongevityMindset
Coming soon: The Longevity Docs Podcast - Cutting-Edge Medicine, No Fluff.
I used to love health podcasts. Until I didn’t. I was listening while cooking, exercising, driving... Then, the same topics kept coming up: the best biomarkers, the best diet, the best exercise, the best sleep hacks. It felt like a loop.
Meanwhile, longevity medicine is evolving faster than ever. Every day in our Longevity Docs community, we discuss cutting edge innovations (senolytics, stem cells, peptides, plasmapheresis, AI diagnostics.... ). The kind of knowledge I wish every physicians can have access to.
So I decided to start something new: The Longevity Docs Podcast
A place where the world’s top minds in longevity share their journeys, frameworks, and philosophies on what actually works in patient care. This isn’t just another health podcast. It’s a platform for doctors passionate about longevity medicine.
Stay tuned. Launch date coming soon!
PS: My first guest was the brilliant Dr. Elizabeth Yurth. Our conversation explored cellular pathways and the philosophy of longevity medicine, diving deep into our she practices longevity medicine.
Longevity Medicine Education: 4 Weeks Until Our Hormones Mastermind in NYC!
For the first time, we’re curating a full-day curriculum on hormone optimization and longevity, featuring 10 world-leading experts. Our goal is to make cutting-edge longevity medicine more accessible globally.
Can’t join us in NYC? No worries! This mastermind will be live-streamed on our app, giving you 10 hours of expert-led hormone education: more exciting than your favorite Netflix series! 🔥
Meet some of our Faculty:
This what you’ll get:
1-DAY IN-PERSON PASS
Enjoy 1-day access to all programming at Longevity Docs Mastermind Hormones.
Includes:
Full access to all Longevity Docs Mastermind Hormones sessions in person on March 29, 2025
Digital on-demand access to all talks post-event
Invitation to the Welcome Cocktail on March 28, 2025
Complimentary chef-curated lunch
Entry to meeting and networking spaces
Access to exclusive networking opportunities through the official event app
Complimentary Wi-Fi at Convene
Access to select 4-star hotel rooms at preferential rates in the heart of New York (hotel cost not included)
Tickets: $495
DIGITAL-ONLY PASS
Experience Longevity Docs Mastermind Hormones from anywhere with full virtual access.
Includes:
Livestreamed access to all sessions on March 29, 2025
On-demand access to talks until May 1, 2025
Tickets: $295
VIP DINNER ADD-ON
Limited to just 50 guests, this exclusive dining experience offers a unique opportunity to connect with top Longevity Docs Mastermind Hormones experts.
Includes:
Private dinner with leading experts from Longevity Docs Mastermind Hormones on March 29, 2025
Does Fasting Cause Temporary Insulin Resistance?
Buzz: One Doc observed glucose spikes after breaking his fast, prompting discussions on the second meal effect and meal composition’s role in glucose control.
Key Takeaways:
Time Restricting Eating (TRE) such as one-meal-a day may reduce the first-phase insulin response and glucose tolerance
This would make it advisable to avoid large meals with a very high glycemic load when following TRE with an eating window of less than 4 hours.
Light exercise during fasting (e.g., walking 10K steps) may support better metabolic adaptation.
Hormone Therapy and Clotting Risks: Oral vs. Transdermal Estrogen
Buzz: the safety of oral vs. transdermal estrogen for patients with clotting risks.
Key Takeaways:
There is some conflicting evidence regarding whether oral estrogen significantly increases the risk of venous thromboembolism (VTE), with certain studies suggesting that the risk may not be as high as previously thought.
Oral estradiol certainly has less VTE risk than CEE (at least 30% less) and has never been shown in RCTs to increase clot risk (but those weren't looking for VTE as primary endpoints).
Oral estradiol it's best to avoid it in people with potential clotting disorders or those at high risk.
Clinicians should assess clotting factors before prescribing HRT.
Welcoming New Longevity Docs
Longevity Docs unites board-certified physicians from diverse specialties - including cardiology, endocrinology, surgery, psychiatry, public health, regenerative, and functional medicine - across private practice, academia, and health systems worldwide.
Jay Luthar, MD: Boston, MA - USA
Kathleen Jordan, MD: San Francisco, CA - USA
Richard Bana, MD: Székely - Hungary
Amy Louis Bayliss, MD: Toronto - Canada
Val Koganski, MD: Langhorne, PA - USA
Thomas Westin, MD: Askim- Sweden
Luke Sorrell, MD: Irving, TX - USA
You are a physician(MD/DO, MBBS) interested in longevity medicine. Connect with us!
Peter Attia’ Biograph Longevity Clinic is out of stealth: What Does It Mean for Longevity Docs?
by Dr. David Luu
Dr. Peter Attia, one of the most influential voices in longevity medicine, is officially launching Biograph, a longevity clinic emerging from stealth after being co-founded in 2017. This signals a growing trend: the rise of brick-and-mortar longevity clinics offering advanced diagnostics and preventive care for those willing to invest in their healthspan.
But Biograph isn’t launching into an empty market. The longevity clinic space is already expanding with multiple models at different price points:
Atria ($60,000/year) - The most exclusive clinic in NYC and Palm Beach, which I recently visited. Atria offers a 5-star concierge experience with a care team of dozen of physicians, advanced diagnostics, and a comprehensive focus on disease prevention and management.
Biograph ($7,500-$15,000/year) - Positioned as a high-end but more accessible option, offering whole-body MRI, AI-driven diagnostics, and metabolic screenings without the full concierge experience.
Function Health ($499/year) - A more mass-market approach, scaling rapidly with a Series B funding round to make comprehensive biomarker testing and AI-driven health insights available to millions. No doctors.
This tiered ecosystem shows one thing clearly: demand for longevity medicine exists at every level, from elite concierge services to affordable subscription-based health tracking.
Limitation: where are the longevity physicians?
While these clinics and platforms are capital-intensive, data-driven, and focused on early detection, many still lack a crucial element:
Longevity physicians who can turn diagnostics into real outcomes
Patients don’t just need numbers: they need expert guidance on interventions, from lifestyle optimization, to metabolic treatments, peptides management, to regenerative therapies guidance.
Right now, most longevity clinics focus on diagnostics, offering AI-driven imaging, biomarker testing, and genetic risk assessments. But patients don’t just need test results—they need expert guidance, personalized treatment, and longevity optimization strategies. This is where the biggest opportunity for longevity medicine lies.
Opportunity: longevity physicians as free agents?
This is where independent longevity doctors can redefine the field:
Acting as free agents, they can offer high-touch, expert care that these clinics currently lack.
Partnering with clinics like Biograph, Atria, and Function Health, they can translate diagnostics into actionable longevity roadmaps, ensuring patients don’t just get reports, but real interventions.
Serving patients across multiple platforms, rather than being tied to a single clinic, bridging the gap between advanced testing and effective, personalized treatments.
This is the next phase of longevity medicine: where diagnostics meets expert intervention, and physicians play a pivotal role in guiding patients beyond early detection into true health optimization.
Thoughts: the future of longevity will be guided by physicians
With Attia’s Biograph launch, Function Health’s Series B, and Atria’s premium concierge model, the longevity clinic market is just getting started. But as these clinics scale, the demand for longevity-trained physicians will only increase.
This is the moment for physicians in longevity medicine to step up, elevate the field, and create a new standard of care: one that goes beyond diagnostics to deliver real, evidence-based interventions that extend both lifespan and healthspan.
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels
These findings demonstrate the therapeutic potential of durable and reversible epigenetic editing in vivo and support the development of epigenetic editor–based treatment for hypercholesterolemia.
Nature - Recommended by Dr. Steve Murphy
Skin Anti-aging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial
A clinical–instrumental study was conducted on 96 Caucasian subjects with mild-to-moderate facial aging to demonstrate the efficacy of probiotic intake combined with topical ectoin and sodium hyaluronate.
Cosmetics - Recommended by Dr. Cother Hajat
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
This study demonstrates that we can improve BBB function and reduce neuroinflammation and cognitive deficits in aged mice by restoring core 1 mucin-type O-glycans to the brain endothelium using adeno-associated viruses.
Nature - Recommended by Dr. Neil Paulvin
Awareness, knowledge, and motivations about lifespan, healthspan, and Healthy Longevity Medicine in the general population: the HEalthy LOngevity (HELO) conceptual framework
The HEalthy LOngevity (HELO) framework was developed through a literature review guided by expert discussions across disciplines to include evidence-based concepts of health-related decision-making, ageing, and HLM. The framework organises concepts into three components. The first two components, awareness and knowledge, explore public perception and understanding of the healthy longevity field, respectively. The third component, motivations, reflects factors underlying motivations towards healthy longevity.
Geroscience - Recommended by Andrea Maier
Longevity Docs Hormones Mastermind
📅 Date: March 29, 2025
📍 Location: Convene 101 Park Ave, New York (In-person & Digital Access Available)
One-day, 10-course curriculum
featuring dozen world-renowned experts, offering an unique opportunity to elevate your expertise in hormonal health and longevity medicine.
Learn directly from an unparalleled lineup of physicians, including:
Drs. Amy Killen, Jessica Shepherd, Elizabeth Yurth, Angela DeRosa, Salome Masghati, Juan Bautista, Felice Gersh, Melissa Loseke, Marcos de Andrade, Elizabeth Poynor, Kyle Gillett.
Longevity Docs Cannes
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
Others Events
Vitalist Bay - Berkeley, CA, Apr 4 - May 29
The Longevity Med Summit - Lisbon, May 6-8
Life Summit - Berlin, May 27-28
Startup co-founded by longevity guru Peter Attia emerges from stealth
Biograph, a new health-focused startup co-founded by Dr. Peter Attia, has come out of stealth mode. While specifics are limited, the company is expected to integrate cutting-edge longevity research into clinical practice. The initiative highlights a growing movement toward personalized and preventive longevity care. TechCrunch
The quest for a “communication device” that tells cells to regenerate the body
What if medicine could harness the body’s innate healing ability with precision, using technology to direct the body to repair damaged tissues and organs, or even regenerate them entirely? Michael Levin talks about the future of regenerative and bioelectric medicine — and the quest to build a device that can communicate with cells, steering their behavior toward our desired health goals. Big Think
From lifespan to healthspan: why childhood nutrition is key to the new longevity
This article explores how childhood nutrition is a fundamental determinant of long-term health and longevity. Early dietary habits influence metabolic health, cognitive function, and the risk of chronic diseases later in life. The piece argues for prioritizing nutrition policies to enhance both lifespan and healthspan. WEF
Antiaging pill for dogs clears key FDA hurdle
The FDA has supported Loyal’s second longevity drug, LOY-002, designed to extend the healthy lifespan of senior dogs. The drug, targeting dogs over 10 years old and 14 lbs or more, aims to improve quality of life and delay aging-related decline. This milestone marks growing interest in veterinary longevity medicine. Washington Post
At Longevity Docs, we offer two distinct membership to support doctors in longevity medicine:
Basic Membership
Become part of a global network of 300 longevity-focused physicians across 50 countries, access to our app, educational resources, and opportunities to attend exclusive events.
Private Club Membership
For those seeking a more immersive experience, the Private Club Membership offers all the benefits of Standard Membership, plus exclusive access to private events, monthly forums, deeper collaboration with experts, and early insights into cutting-edge longevity practices.
Eligibility: Open exclusively to medical doctors operating a healthcare practice or leading a business dedicated to longevity.
Every Doctor Should be a Longevity Doctor
As a heart surgeon, I was often the doctor you hoped never to need . If you were in my operating room it means prevention was no longer an option. My father, a physician specializing in Chinese medicine and acupuncture, taught me about preventive care very early on. At 21, in 2001, I launched a foundation focused on operating on children in Africa, India, Cambodia, and Haiti so they could live longer, healthier lives.
In 2020, everything changed. When my wife contracted COVID-19, I realized the future of medicine lies in prevention. This led me to found a digital clinic dedicated to combating preventable age-related diseases, immersing myself in longevity research and new tech.
However connecting with like-minded doctors was the hardest part. I started a WhatsApp group with a dozen doctors passionate about longevity. We shared publications, new tech tools, and discussed case studies. It quickly grew into something bigger, and I realized we lacked a structured platform to learn, exchange insights, and shape the future of evidence-based longevity medicine.
From this need, Longevity Docs was born. Today, we unite 300 physicians across 50 countries with a shared goal: to democratize longevity medicine. Imagine a world where physicians have access to evidence-based practices, collaborate with experts, and conduct research together - in real-time, anywhere in the world.
I firmly believe that a decentralized, collective intelligence of physicians is the key to extending human healthspan. Together, we can create a legacy where medicine helps people live better.
Dr. David Luu
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.