Longevity Docs Consulting • GLP1-RAs Microdosing • HRT &Perimenopause • Home Clinic Hub • Community as Medicine Skin Rejuvenation
Your sneak peek into the world of Longevity Docs.
Hey Docs,
"A healthy man wants a thousand things, a sick man only wants one." – Confucius.
This week, I felt this firsthand as the flu took me down - a stark reminder that when health is compromised, nothing else matters. It reinforced why longevity medicine isn’t just about lifespan but healthspan, prevention, and resilience before illness forces us to pay attention.
In this week newsletter:
Why We’re Launching Longevity Docs Consulting. As the longevity economy grows, traditional consulting firms lack expertise, and celebrity advisors remain hands-off. Longevity Docs Consulting bridges the gap…
Buzz in the Chat : we discussed GLP-1 RAs “Micro-dosing” and When Should HRT Start in Perimenopause?
What’s Hot in Longevity Tech? I am dissecting three key trends from the Future 100: 2025 report: Home Clinic Hub, Community as Medicine, and Skin Rejuvenation.
Medicine is changing. Are you leading the change?
Happy Sunday!
David
#LongevityMindset
Introducing Longevity Docs Consulting
The first consulting firm for evidence-based longevity medicine, building the infrastructure that powers the longevity revolution.
As longevity becomes a global priority, industries from healthtech and hospitality to beauty, real estate, and finance are racing to integrate longevity into their offerings. At the same time, physicians are seeking leadership roles as CMOs, advisors, and consultants. Yet, traditional consulting firms lack expertise, and celebrity advisors are often too hands-off to drive real impact.
Longevity Docs Consulting powers the longevity revolution as the first consulting firm exclusively dedicated to longevity medicine, building the infrastructure for its future.
As the first consulting firm dedicated exclusively to longevity medicine, we provide organizations and institutions with access to a global network of 400+ top longevity physicians across 50 countries, delivering strategic insights, clinical expertise, and science-backed solutions.
Our mission at Longevity Docs is to democratize longevity medicine by empowering doctors to lead its future and build robust infrastructures across all sectors, expanding human healthspan.
Who we partner with
⚕️Clinics & Health Systems: Launching longevity protocols and integrating next-generation longevity technologies into patient care.
🚀 Startups & Corporations: Developing longevity strategies and designing high-impact longevity products.
🏦 Investors & Family Offices: Identifying longevity-driven innovation opportunities and shaping strategic investment theses.
🌎 Institutions & Governments: Advising on large-scale public health initiatives, longevity policies, and cutting-edge research.
Our 3 Pillars approach
Longevity expert network: Access to top longevity physicians, biotech pioneers, and health-tech innovators, prioritizing expertise over influence
Evidence-based strategy: Rooted in validated research, data-driven evidence, and proven longevity interventions.
Outcomes-focused: Committed to customer health outcomes, long-term value, and credibility in longevity medicine.
The Longevity Revolution has started. Whether you’re building longevity clinics, investing in breakthrough biotech, implementing corporate wellness solutions, or building longevity cities, Longevity Docs Consulting is your strategic partner.
Speaker Spotlight: Hormones and Longevity Mastermind NYC
Get ready to learn from the leading experts in hormone optimization and longevity medicine!
🎟️ Limited to Physicians – Secure Your Spot Now!
Can ultra-low doses of GLP-1 RAs offer metabolic benefits beyond weight loss?
Buzz: The debate on microdosing GLP-1 drugs like semaglutide centers around what constitutes the minimal effective dose; a question that remains unclear. While biomarkers like insulin, HbA1c, and adiponectin can help track responses, the full spectrum of benefits beyond weight loss is still being explored.
Key Insights:
There is no established minimal effective dose for longevity and metabolic benefits. Some practitioners increase the dose until weight stabilizes and energy levels optimize, but this approach remains anecdotal.
GLP-1 drugs influence neurochemistry, addiction pathways, and metabolic regulation beyond appetite control. Emerging research even suggests microdosing (0.25–0.5 mg/week) may reduce alcohol consumption.
Individual genetics and environmental factors could play a huge role in determining response to GLP-1s. Some people need only tiny doses to see effects, reinforcing the need for personalized medicine.
The real breakthrough may lie in understanding microbiotic and enterohormonal changes, which could explain why GLP-1s affect cravings, behavior, and even libido at low doses.
When to Start HRT in Perimenopause?
Buzz: Hormone Replacement Therapy (HRT) in perimenopause remains a highly debated topic among longevity doctors. While some argue that symptoms alone should guide initiation, others emphasize the importance of diagnostics like the DUTCH test and GlycanAge to assess hormonal shifts.
Takeaways:
While some longevity doctors prefer immediate symptom-based treatment, others believe biomarkers like DUTCH and GlycanAge offer more precise timing and insights.
GlycanAge may serve as an early intervention trigger, supporting estradiol use even before hot flashes appear, aiming to prevent systemic inflammation and metabolic decline. The mechanism by which estradiol lowers GlycanAge is still under study. It likely involves epigenetic regulation of glycosyltransferase genes, which modify IgG antibodies. Research in this area is ongoing.
Doctors agreed that each patient’s unique metabolic and hormonal profile should guide therapy, balancing clinical intuition with objective testing.
Welcoming New Longevity Docs
Longevity Docs unites board-certified physicians from diverse specialties - including cardiology, endocrinology, surgery, psychiatry, public health, regenerative, and functional medicine - across private practice, academia, and health systems worldwide.
Efi Roboti, MD: Athens - Greece
Alexander Rakic, MD - Amsterdam, The Netherlands
Ajay Haryani, MD - Brooklyn, NY, USA
Rakesh Patel, MD - Los Altos, CA, USA
Saima Ajaz, MBBS, PhD - London, UK
Sunjya Schweig, MD - Oakland, CA, USA
You are a physician(MD/DO, MBBS) interested in longevity medicine. Connect with us!
What’s Hot? by Dr. David Luu
3 Longevity Medicine Trends Doctors Need to Watch
I came across an insightful report, The Future 100: 2025, highlighting three game-changing trends in longevity medicine: Home Clinic Hub, Community as Medicine, and Skin Rejuvenation.
As healthcare shifts toward AI-driven, decentralized care and socially integrated wellness, one key insight stands out: consumers are prioritizing health and well-being over discretionary spending. This signals a growing demand for proactive longevity care.
The question is: how will doctors evolve to this transformation?
1. Home Clinic Hub
Healthcare is no longer confined to clinics; it is becoming continuous, AI-driven, and decentralized, with wearables, smart sensors, and remote diagnostics enabling real-time, personalized interventions. Patients now expect proactive, data-driven care, and with a 10-million healthcare worker shortfall projected by 2030, decentralization is not just inevitable, it’s essential.
At-home AI diagnostics, smart mirrors, and biometric tracking showcased at CES 2025 confirm that routine monitoring and preventive care are shifting from hospitals to homes. For longevity physicians, this marks a fundamental shift from reactive to proactive medicine, requiring a new model where daily biomarker tracking informs real-time, precision-driven interventions. As Harvard’s Dr. Jag Singh said at SXSW 2024, this is “the beginning of the end of conventional healthcare.”
Longevity doctors must embrace AI, continuous monitoring, and decentralized care models to lead the future of healthspan optimization.
2. Community as Medicine
Social connections are proving to be as vital to health as traditional medicine. Social prescription, originally from the UK, is gaining global traction, emphasizing community-driven activities like group dance, nature therapy, and volunteering to improve mental and physical well-being. Loneliness poses health risks comparable to smoking 15 cigarettes a day, according to the U.S. Surgeon General, and affects 20% of adults daily (PBS, Gallup). This increases risks of cardiovascular disease, dementia, depression, and premature death.
To combat this crisis, community-driven wellness is becoming essential. Remedy Place is pioneering social wellness clubs, blending contrast therapy, breathwork, and group health experiences. Othership integrates sauna, cold therapy, and communal rituals, fostering emotional connection and resilience. Wellness retreats are shifting from solitude to shared experiences and movement-based healing.
For Longevity Docs, this highlights the need to prescribe community alongside medicine. Will social engagement become a medical prescription? The future of longevity care must be holistic and community-driven, ensuring that connection is as vital as biomarkers in optimizing healthspan.
3. Skin Rejuvenation
Skin health is no longer just about aesthetics, it is emerging as a key marker of longevity. Recent research suggest that skin aging may contribute to systemic aging, making rejuvenation a critical focus in longevity medicine.
Researchers at Wellcome Sanger Institute (UK) have successfully grown skin from stem cells, a milestone that could lead to anti-aging treatments, scar prevention, and artificial skin transplantation. Meanwhile, studies from Portugal’s Center for Neuroscience and Cell Biology link senescent (zombie) cells in the skin to accelerated aging in organs, including the brain, reinforcing the connection between skin health and overall biological aging.
This shift is already driving innovation. OneSkin (backed by its $20 million Series A funding) is pioneering topical anti-senescence skincare with its OS-01 peptide, designed to reverse the skin’s biological age. L’Oréal’s Cell BioPrint, unveiled at CES 2025, leverages AI-driven skin analysis to assess aging markers and personalize skincare regimens.
For Longevity Docs, this marks a paradigm shift: skin rejuvenation is now a form of preventive medicine, not just aesthetics. As research links skin aging to systemic aging, maintaining skin health becomes as crucial as tracking biomarkers, positioning the skin as a vital organ in longevity optimization.
Evaluation of off-label rapamycin use to promote healthspan in 333 adults
In order to begin to capture real-world data on people using rapamycin off-label for putative healthspan-promoting benefits, we established an online data bank where people could self-report their experiences taking rapamycin.
Geroscience - Recommended by Dr. Tom Rifai
Once-Weekly Semaglutide in Adults With Alcohol Use Disorder
These findings provide initial prospective evidence that low-dose semaglutide can reduce craving and some drinking outcomes, justifying larger clinical trials to evaluate GLP-1RAs for alcohol use disorder.
JAMA Psychiatry - Recommended by Dr. Sajad Zalzala
Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination
To investigate immunological features in people suffering from persistent symptoms after COVID-19 vaccination, a cross-sectional case-control study was undertaken to identify the immunological correlates of PVS.
Pre-print Medrxiv - Recommended by Dr. Alan Katz
Longevity Docs Club Forum
📅 Date: February 28, 2025
📍 Location: Virtual
Guest Speaker: Roy Bejarano - Co-founder and CEO of Scale Healthcare
This event is reserved for private members of the Longevity Docs Club - request info at meriem@longevitydocs.org
Longevity Docs Hormones Mastermind
📅 Date: March 29, 2025
📍 Location: Convene 101 Park Ave, New York (In-person & Digital Access Available)
One-day, 10-course curriculum
featuring dozen world-renowned experts, offering an unique opportunity to elevate your expertise in hormonal health and longevity medicine.
Learn directly from an unparalleled lineup of physicians, including:
Drs. Amy Killen, Jessica Shepherd, Elizabeth Yurth, Angela DeRosa, Salome Masghati, Juan Bautista, Felice Gersh, Melissa Loseke, Marcos de Andrade, Elizabeth Poynor, Kyle Gillett.
Longevity Docs Cannes
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
Others Events
Founders Longevity Forum - Singapore, February 27-28
Vitalist Bay - Berkeley, CA, Apr 4 - May 29
The Longevity Med Summit - Lisbon, May 6-8
Life Summit - Berlin, May 27-28
Chi Longevity launches ‘world’s first’ evidence-based healthy longevity gym
Singapore clinic acquires brain-body fitness firm Sparkd and integrates optimization of cognitive performance and physical health. LT
Level Zero Health banks $6.9M to prove wearable medtech can take the strain out of hormone testing
Level Zero Health, a female-founded medical device startup that’s aiming to break new ground by developing a device for continuous hormone monitoring, has closed an oversubscribed $6.9 million pre-seed funding round despite being only a little over a year old. TechCrunch
Shares of Hims & Hers tumble 26% after FDA says semaglutide is no longer in shortage
The FDA said the shortage of semaglutide injection products such as Novo Nordisk’s Ozempic and Wegovy has been resolved. The agency said it will start taking action against compounders, which are allowed to produce custom-made alternatives to brand-name drugs during shortages, for violations in the next 60 to 90 days. CNBC
At Longevity Docs, we offer two distinct membership to support doctors in longevity medicine:
Basic Membership
Become part of a global network of 300 longevity-focused physicians across 50 countries, access to our app, educational resources, and opportunities to attend exclusive events.
Private Club Membership
For those seeking a more immersive experience, the Private Club Membership offers all the benefits of Standard Membership, plus exclusive access to private events, monthly forums, deeper collaboration with experts, and early insights into cutting-edge longevity practices.
Eligibility: Open exclusively to medical doctors operating a healthcare practice or leading a business dedicated to longevity.
Every Doctor Should be a Longevity Doctor
As a heart surgeon, I was often the doctor you hoped never to need . If you were in my operating room it means prevention was no longer an option. My father, a physician specializing in Chinese medicine and acupuncture, taught me about preventive care very early on. At 21, in 2001, I launched a foundation focused on operating on children in Africa, India, Cambodia, and Haiti so they could live longer, healthier lives.
In 2020, everything changed. When my wife contracted COVID-19, I realized the future of medicine lies in prevention. This led me to found a digital clinic dedicated to combating preventable age-related diseases, immersing myself in longevity research and new tech.
However connecting with like-minded doctors was the hardest part. I started a WhatsApp group with a dozen doctors passionate about longevity. We shared publications, new tech tools, and discussed case studies. It quickly grew into something bigger, and I realized we lacked a structured platform to learn, exchange insights, and shape the future of evidence-based longevity medicine.
From this need, Longevity Docs was born. Today, we unite 300 physicians across 50 countries with a shared goal: to democratize longevity medicine. Imagine a world where physicians have access to evidence-based practices, collaborate with experts, and conduct research together - in real-time, anywhere in the world.
I firmly believe that a decentralized, collective intelligence of physicians is the key to extending human healthspan. Together, we can create a legacy where medicine helps people live better.
Dr. David Luu
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.