Longevity Docs Announce Cannes Festival and Awards | CAC vs. Cleerly | Rapamycin for Dogs

Your weekly sneak peek into the world of Longevity Docs.

Jun 16, 2024

Hi Longevity Docs!

In 1959, my dad arrived in Cannes from Laos. He became a medical doctor and one of the leading acupuncturists, playing a pivotal role in democratizing acupuncture and helping to establish it as a recognized medical specialty.

Two days ago, I visited the iconic Palais des Festivals in Cannes, and I am super excited to announce that we are launching our Festival and Awards next year in Cannes. Following in the footsteps of the renowned Cannes Film Festival and Cannes Lions Festival of Creativity, we proudly present the Festival of Longevity. The world’s leaders in the field will gather to shape the future of longevity medicine, technology, life sciences, and culture.

Full circle, Dad, you are an inspiration. ❤️

Happy Father’s Day to all the dads!

David

🚨 Longevity Docs News

👋 Community: Welcome to our new members

Andrea Gartenbach - Berlin, Germany
Molly Maloof - Austin, USA
Elizabeth Poynor - NYC, USA
Laura Lile - Georgia, Tennessee, Michigan, USA
Mayoni Gooneratne - UK
Johan Hedevåg - Stockholm, Sweden

🎤 Longevity Docs Events

🇺🇸 Mastermind - NYC, October 5-6, 2024

Book Early-Bird Ticket

🇫🇷 Festival & Awards - Cannes, June 25-27, 2024

Save the date. Update coming soon.

💬 Buzz in the Chat

What is best way to explain to patients the risk when their cardiologist tells them they’re fine with high lp a, ApoB, ldl-p , oxidized ldl. Many cardio say your cac is fine no treatment is necessary.

Is anyone seeing cac score of 0 and then not great Cleerly. I understand this includes soft plaque. Then are cac’s missing a lot.
Yea I have seen several patients with CAC 0 yet not good Cleerly.
CAC def a lagging indicator in my mind, understanding that atherosclerosis develops over decades.
Hence agree with u that concerning ApoB, Lp(a), oxLDL should not be ignored with CAC 0.
I walk thru the long process of how plaque forms over decades and patients get it very fast.

Would you use population percentile scores or below 70/80 optimal for most people

It can take 5 or more years to calcify plaque. CAC identifies a later stage of disease. Cleery is clearly superior from a proactive perspective
I have a growing number of patients with CAC of 0 and significant non-calcified plaque by CLEERLY
Event-free survival according to the presence or absence of statin therapy post-coronary CT angiography among patients with non-obstructive coronary artery disease, stratified by extent of disease according to segment involvement score (SIS). CCTA, coronary CT angiography; CV, cardiovascular; MI, myocardial infarction. Reproduced from Hulten et al32 with permission from Wolters Kluwer Health.
I find this CCTA to be incredibly motivating for the patient- especially in light of the very high rates of discontinuing treatment.
I start every visit by showing the patient their coronary anatomy, so that they are reminded why they are on a specific treatment
I’m glad to hear all of this. It’s weird fighting with highly trained cardiologist about difference of types of plaque. Plus how inflammation is involved let’s treat that since we have specific markers for this.
Welcome to my world.
Every day I have discussions with excellent cardiologist colleagues who have never heard either of CLEERLY or Boston Heart.
This is the problem with corporate medicine - if one sees 50-90 patients daily ( I have a cardiology friend who does this with 2 NPs) there is no way one has the time to go over these types of tests

Anyone else have their dogs on rapamycin? Would love to hear experiences, best practices etc

Same here - but for cats. Contemplating starting Milne of mine on rapa, he already has CHD.
I have my dogs on it. I'm doing 0.1 mg/kg weekly but can't remember where I got that.
Probably from Matt Kaeberlein and his group: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365

Docs , how usually measures Vo2 max in yours patients ?

I used to do cardiopulmonary exercise testing with Vo2max on everyone but after doing it once or twice, most people chose to avoid it because it is unpleasant. Now it is infrequently done.
PNOe is a really nice easy way to measure vo2 max if you have a system or can find one near you. Interestingly somalogics proteomic testing gets a fairly accurate vo2max just from proteomics. It is such an indicator of health that I do think we should incorporate vo2max testing more
http://vo2master.com/ - I am testing this next week, they are US based , supposed to be the one that Attia mentioned in his podcast back then. But I haven't checked it. There is still no good valid product in Germany 🥹
The VO2 Master Analyzer measures breath-by-breath ventilation and VO2, but it doesn't have a CO2 sensor and can't capture VCO2. Limited capabilites!
None of the commercial portable units good at CO2 yet. Best evidence for Calibre. But usability apparently a challenge especially for multiple users
PNOE...does both.. Haven't tried Calibre out yet but is has a way to go per developer.
VO2master’s next unit will apparently have CO2 which is what the Norwegian triathletes are using with their coach who’s the one that convinced Attia live on air
I've stopped using Calibre as it was sweaty and didn't sync well.
Biggest issues with all devices is accuracy, reliability, overly hyped capabilities and support. We should have a master list of just devices to share Objective and subjective experience. Real world non fake reveiws. And then when we see real.world evidence of positive benefits we can then do indepth validation. Most are too busy but our plan is to do just that as if we can reliable measure we can't optimize performance nor show benefits of regeneration or increased resilience.
I love this
I think the challenege is “vs what”?
CGM as an example, to use a finger stick as gold standard makes sense on the surface, but doesn’t when you start to think about the dynamics of interstitial fluid vs blood.
Sleep as another example, PSG is gold standard but the agreement of sleep scientists for the same study isn’t 100% (much lower from memory). So it can be hard to not throw devices out, perhaps prematurely.
Yes and yes. What did we need in clinic for assessment and then what is good enough or easy enough to make sure interventions are heading in the correct direction. Can't rely on Oura for sleep staging but maybe sleep time for some is enough. For me it is not sufficient.

🩺 Publications

Remote monitoring technologies for measuring cardiovascular functions in community-dwelling adults: a systematic review

The top four most reported technologies were AliveCor KardiaMobile®, Fitbit Charge 2, and Polar H7 and H10 Heart Rate Sensors. With over 200 distinct RMTs reported, this review provides healthcare professionals and researchers an overview of available RMTs for monitoring the cardiovascular system.

Geroscience - Recommended by Dr. Andrea Maier

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

Our results showed no clinical side effects in the rapamycin-treated group compared to dogs receiving the placebo. Echocardiography suggested improvement in both diastolic and systolic age-related measures of heart function (E/A ratio, fractional shortening, and ejection fraction) in the rapamycin-treated dogs.

Geroscience - Recommended by Dr. Sajad Zalzala

Gerogenes and gerosuppression: the pillars of precision geromedicine

Tumorigenesis is driven by the gain-of-function mutation or overexpression of oncogenes, as well as by the inactivation of oncosuppresssive (tumor suppressor) genes due to their loss-of-function mutation, genomic loss, or epigenetic silencing.

Nature - Recommended by Dr. David Luu

🗓️ Events & conferences

👉 Longevity Docs Mastermind: New York City - October 5,6
Longevity Docs Festival & Awards: Cannes, France - June 25,27 2025
LiveLong Summit: Los Angeles - August 3,4
ARDD: Copenhagen, Denmark - August 26,30

About Longevity Docs

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