Longevity Conference Makeover - Glycocalyx for Arterial Health - Gen Z Leads the Longevity Economy
Issue 49: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
I just returned from the Super Human conference - energized and reflective. The truth? At every event I attend, what stays with me isn’t the slides or booths. It’s the people. The connections. The experience.
The science and technology? I dive deeper into that after. But it’s the human moments that spark lasting impact.
This week’s newsletter is a special one:
Why we’re reinventing longevity conferences
10 reasons Gen Z is shaping the future of longevity
The Buzz in the chat on Glycocalix
Happy Sunday!
Why We’re Reinventing Longevity Conferences
Most longevity events feel like sales expos. Same molecules. Same booths. Same slide decks.
But that’s not why we’re here.
As one of our Longevity Docs Dr. Elizabeth Yurth said:
“One of the reasons I love being part of these conferences so much isn’t just the science. It’s the people.”
That’s why we redesigned everything.
The Summit Begins Before the Science
We start the night before with a sunset cocktail on the private beach deck of the Majestic Hotel on La Croisette.
Mornings Start with Movement & Community
Each day opens with energy. You can join a run along La Croisette or plunge into the Mediterranean for a saltwater swim. Because community isn’t built in lecture halls, it’s built in shared rituals.
A Studio, Not a Stage
Our sessions aren’t back-to-back PowerPoints.
We’ve turned the conference room into a broadcast studio, cinematic, intimate, interactive. You’ll hear from longevity scientists, tech founders, policymakers, and investors shaping the next decade of health.
Healthy Lunch of the Beach
At most conferences, lunch means a cold ballroom, processed snacks, and a frantic search for fast food. Not with us. Healthy meals will be served on the beach so you can refuel, connect, and stay in flow under the sun.
Longevity Docs Awards Gala
Instead of a loud afterparty, we’ve curated the first-ever Longevity Docs Awards Gala held at the iconic Carlton Grand Salon. Tuxedos. Recognition. Community.
A black-tie celebration for those shaping the future of healthspan.
Private Yacht Party (by invitation only)
The Summit ends with a yacht experience in the port of Cannes because we’re not just talking about longevity. We’re living it.
Tickets Are Limited
Every guest is vetted. Every moment is curated.
If you're ready to step into the circle building the future of medicine
Cannes is calling.
Gen Z Is Redefining the Longevity Economy
The $2T wellness industry isn’t being driven by retirees, it’s being rebuilt by 20-somethings.
According to McKinsey Report, Gen Z and Millennials now account for 41% of global wellness spending. But this isn’t about aesthetics or fads. It’s a new operating system, where longevity starts long before disease.
Here’s why this generation is leading the revolution:
7 reasons why Gen Z will shape the future of Longevity Medicine
They start early: Longevity isn’t for retirement. They optimize mitochondria, sleep, and gut health before 30.
They want proof, not promises: HRV, glucose, blood test - if it’s not backed by data, it doesn’t earn trust.
They’re AI-native: Uploading labs to ChatGPT? Already happening. They expect digital health to speak their language.
They’re skeptical and that’s good: They’ll try your protocol, but they’ll fact-check it before, during, and after.
They think in systems: Not “fix my symptom.” They want interconnected protocols for mind, metabolism, and performance.
They made it social: Longevity is no longer fringe, it’s content, community, and cultural currency.
They’re building the future: Founders, creators, investors—they’re not just joining the longevity economy. They are the economy.
What Longevity Docs Should Do
Reframe protocols: Lead with performance—energy, focus, recovery
Show fast wins: Highlight short-term benefits with long-term impact
Train your team: Understand HRV, sleep scores, biological age
Design Gen Z tracks: Think cognitive fitness, hormone balance, skin health
Partner smart: Work with trusted voices to bridge science and culture
Gen Z isn’t just your future patient.
They’re your now. And if you’re not speaking their language someone else will.
Glycocalyx in the Spotlight
This week, Longevity Docs peers were deeply engaged in discussion around glycocalyx health, sharing protocols, clinical tools, and real-world outcomes.
Do you prefer over exosomes for wound healing?
Increase NO production, Also, improve the endothelial glycocalyx. If possible get a Glycocheck on the patient. If score is low, the above products will help greatly
I agree with the clinical importance of the glycocalyx but the limitation for me is not seeing any changes in clinical outcomes with use of any of those supplements. I havent seen it make any marked changes besides change the measurements in highly specialized and difficult to obtain tests.
I use both EndoPat and Vendys and find them to be similar- which would be expectedGlycocheck may have too much variability to be relied on definitively
The studies on the supplements that are widely marketed (ie Aterosil) do not have good data to back them up- expensive placebos
The newer “quick” Glycocheck systems may lack reproducibility however we have one of the research models that all the major research universities use. Having done hundreds of Glycocheck tests and repeat tests on multiple people I can tell you we have no issues with reproducibility. Further, I can also say that we do see significant improvement in scores with Endocalyx Pro and RegeneVasc. I have only tested one person on Arterosil. He had a very high score. So, my experience is that the supplements do work and are not “expensive placebos”. Perhaps we have great reproducibility because I do the test myself on all the patients rather than have a tech do them. There is a bit of an art to performing the test.
Takeaway for Clinicians
Combine objective monitoring tools (e.g., Glycocheck, EndoPAT) with lifestyle and dietary protocols to support glycocalyx health.
Consider evidence-backed supplements (like glucosamine/fucoidan blends) only after monitoring and alongside lifestyle interventions.
What to Watch
Upcoming trials using glycocalyx-focused interventions for aging, diabetes, and cardiovascular disease.
Emerging point-of-care endothelial assessments that might make glycocalyx monitoring accessible in longevity clinics.
Want to be part of the WhatsApp group?
Join 400+ Longevity Docs exchanging protocols, insights, and clinical breakthroughs in real time.
Effects of 4‑Month Treatment with Glycocalyx Dietary Supplement on Endothelial Glycocalyx and Vascular Function After COVID‑19 Infection
Demonstrated significant improvement in glycocalyx integrity, arterial stiffness, and oxidative stress markers after 4 months of glucosamine sulfate + fucoidan supplementation in post‑COVID patients. Eur J Clin Invest
The Effect of 4-Month Treatment with Glycocalyx Dietary Supplement on Endothelial Glycocalyx Integrity and Vascular Function in Patients with Psoriasis
Randomized trial in 50 psoriasis patients showing improved endothelial glycocalyx integrity and arterial stiffness using a glucosaminoglycan/fucoidan blend over 4 months Nutrients
Dietary ingredients inducing cellular senescence (CS) in animals and humans: A systematic review
High-fat diets and anti-cancer natural products promote CS in animal models. Preliminary human evidence suggests similar effects from high-protein, red meat-based diets, or DHA-enriched fish oil. Further research is needed to clarify mechanisms and guide dietary and public health recommendations. Mech Ageing Dev
Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
A 3-year structured exercise program initiated soon after adjuvant chemotherapy for colon cancer resulted in significantly longer disease-free survival and findings consistent with longer overall survival. N Engl J Med
1. Aeon Raises €8.2M to Scale AI-Powered Full-Body Health Checks
Swiss startup Aeon secured €8.2M to expand its 60-minute MRI + biomarker + AI diagnostic platform across Europe.
Why it matters: Clinics offering concierge-level diagnostics or partnering with platforms like Aeon can stand out with early detection, precision, and trust.
Watch: Expansion into Switzerland, Germany, UK—via insurer and employer models.
Cholesterol Drugs Go Next-Gen - And Longevity Clinics Should Prepare
Barron’s spotlights new therapies disrupting heart care:
Oral PCSK9 inhibitors from Merck & AstraZeneca
Gene-editing one-shot cures from Verve & CRISPR
siRNA & antibody injections targeting hard-to-lower lipids
Big market potential: $5B+ for pills alone; one-time gene therapies could replace decades of statins.
Why it matters: Clinics can lead by integrating:
Genetic screening (PCSK9, ANGPTL3, Lp(a))
Fast access to novel therapeutics as they hit approval
Prevention-first care models aligned with payer incentives
Geviti Raises $8.5M to Build the Longevity Stack
Longevity startup Geviti closed an $8.5M seed round to advance its consumer health platform combining supplements, biological testing, and digital coaching.
Geviti’s stack reflects a growing trend: science-backed, DTC wellness products powered by personalized data. Clinics should anticipate increased patient expectations for integrated digital-lifestyle offerings.
Longevity Docs Summit Cannes
Join the world’s most visionary longevity physicians, scientists, and innovators for two days of breakthroughs, discoveries, and high-level networking under the French Riviera sun.
Summit. Awards & Black tie Gala. Expo.
Speakers include: Dr. Eric Verdin, Naveen Jain, Dr. Olivier Veran, Lorraine. Cortez-Vazques, Dr. Elizabeth Yurth, Dr. Craig Koniver, Dr. Abid Husain, Dr. Jonathan Kuo, Dr. Darshan Shah, Dr. Matt Dawson, Dr. Tsin Uin Foong, Dr. Anant Vinjamoori, Dr. Amy Killen, Dr. Albert Pradeep, Dr. Tamsin Lewis, Dr. Patrick Sewell, Dr. Dobri Kiprov, Dr. Steven Murphy, Dr. Evelyne Bischof, Dr. Guenole Addor, Dr. Robin Rose, Dr. Anna Erat, Saad Alam, Alejandro Bataller, Dr. Muhammad Alhammad, Vania Lacascade, Marc P. Bernegger, Yianni Psaltis PhD, Dr. Jack Kreindler, Dr. Alexandra Bause PhD, Kayla Barnes-Lentz, Dr. Tania Elliott
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Longevity Conferences Calendar
Dublin Longevity Summit: Dublin, July 2–4
ARDD: Coppenhagen, August 25-29
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.