Launching Longevity Docs Concierge • Immune Aging • HRV • Ipsos Wellness Report 2025
Issue 58: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
Over the past months, I’ve been asked the same questions from both sides:
Patients: “Where can I find the right longevity doctor?”
Doctors: “How do I reach patients who value trusted longevity care?”
Amex can get you palaces, jets, Michelin stars, and front-row seats but it can’t unlock access to the world’s top longevity doctors.
That’s why we’re quietly testing Longevity Docs Concierge in 4 U.S. cities: an invitation-only concierge service connecting those who seek the best in longevity medicine with our top physicians.
I’d love your feedback on this program, and together I hope we can make longevity doctors easier to find and ultimately increase access to trusted longevity care globally.
In this week newsletter:
Inside Longevity Docs: Longevity Docs Concierge
Buzz in the Chat: Akkermansia • HRV
Cover Story: Why Doctors Must Think Like Startups
Research Radar: The immune system offers a window into aging • Immune system influence on physiology • Pulse rate variability is not the same as heart rate variability
Longevity Intelligence: Fountain Life raises $18M • Whoop and FDA
Longevity in the News: Ipsos Wellness Report 2025 • Chasing Longevity • GLP-1 weight-loss pills are coming.
Healthy Sunday!
Longevity Docs Concierge
The White-Glove Connection Between Patients and the World’s Top Longevity Doctors
Finding a trusted longevity doctor is harder than it should be. Many people waste time searching online, bouncing between clinics, and wondering if they’re really getting the best care. It’s overwhelming, and often discouraging.
With 500+ physicians across the world, Longevity Docs carries a responsibility: to guide patients with clarity and to empower doctors with the right tools and network. It’s time to bridge the gap and bring trust, quality, and innovation into longevity medicine.
That’s why we created Longevity Docs Concierge: a private, white-glove service that connects you directly to vetted, world-class longevity physicians in NYC, LA, Miami, and San Francisco.
Our Concierge is invite-only.
We’re opening access to a small group of pioneering patients and physicians.
Why Doctors Must Think Like Startups
Axios recently reported that America’s doctors are working harder, earning less, and going bankrupt at record levels. Despite delivering more care since the pandemic, stagnant reimbursements, inflation, and rising labor costs have left physicians squeezed. Many are selling their practices to private equity or health systems, trading away autonomy while corporatization drives prices up and erodes patient trust.
The system was not built for doctors to thrive.
That’s why the future belongs to those who reinvent themselves as entrepreneurs.
Operating like a startup means:
Owning your equity instead of working for diminishing reimbursement or another health system.
Innovating faster by bringing new science: biomarkers, AI, therapies, directly to patients.
Building sustainable care models with memberships and protocols instead of relying on outdated reactive consultations
Designing patient-first care focused on prevention, optimization, and outcomes
Every startup begins with a bold vision and builds systems, teams, and technology to scale it. The same mindset will allow physicians to reclaim autonomy, grow sustainable practices, and shape the future of medicine.
Here is short checklist doctors could use
Checklist: How Physicians Can Think Like a Startup
✅ Define your offering and audience: are you optimizing heart health, hormones, or full-spectrum longevity? Who do you serve? Be crystal clear.
✅ Start lean: test your model with minimal staff, digital tools, and focused services before expanding. avoid over investing in shinny tech and devices, you are not a med spa
✅ Build recurring revenue: replace fee-for-service with memberships, programs, or subscriptions for predictable income.
✅ Leverage technology: use AI, wearables, and digital platforms to scale reach, automate follow-up, and track outcomes.
✅ Brand yourself like a founder: create visibility through thought leadership, media, and community. Patients and investors buy into you before your clinic.
✅ Focus on outcomes: your KPIs should be health outcomes and should be able to measure and published them
✅ Create partnerships: collaborate with other docs, labs, hospitalities, and tech startups instead of competing against them.
✅ Fail fast, adapt faster: test services (protocols, memberships, products). Double down on what works, cut what doesn’t.
✅ Build culture & team: this is the most important part, you are has good as your front desk experience ;). Build a culture of high end service, trust and kindness.
Of course, being a good doctor means practicing excellent medicine and delivering strong outcomes. But adopting an entrepreneurial mindset can ensure the long-term success and impact of your clinic.
I saw a Akkermansia post. Any nuisances or ideas to support it?
As beneficial as it might be, I have seen patients with extremely elevated levels of akkermansia while still having deficiency dysbiosis, which was surprising to me. That being said, I take a pendulum product that contains it, recommend the brand to patients, and don’t routinely test before recommending.
As beneficial as it might be, I have seen patients with extremely elevated levels of akkermansia while still having deficiency dysbiosis, which was surprising to me. That being said, I take a pendulum product that contains it, recommend the brand to patients, and don’t routinely test before recommending.
I agree as we haven't seen much improvement with the Pendulum product in my patients.
I agree, it is not probably a bacteria that is always so good. As it feeds on mucin, if person does not have enough mucin producin bacteria and fiber in food it might be maybe harmful . I have seen anorectic women or people with very significant dysbiosis and very high akkermansia. Also various polyphenols works very well on increasing akkermansia e.g. Cranbarries, pommegranate
Can anyone explain HRV on Oura rings? I’ve got a patients doing well everywhere and HRV is 10-13
It’s just how Oura calculates HRV. They use overnight RMSSD averaged across the whole sleep period, so the numbers look lower than short-term or “best moment” checks. Biostrap matches closely since it also uses sleep-based RMSSD, but Elite HRV and HeartMath use short recording windows and often catch higher parasympathetic peaks. Oura also applies aggressive filtering to remove ectopics and motion noise, which can push values down further. That’s why someone who’s healthy and performing well can still show 10–13 on Oura while scoring much higher on other platforms
It’s a pretty standard calculation. The average of all the 5 minute RMSSD’s while algo thinks you’re asleep. I find Morpheus chest strap ECG and app helpful. Short window but it prompts user to take reading at same time each day, reducing that variance. HRV has a diurnal pattern. Very affordable. Also, timing of last meal is critical. Late meals and light exposure trash HRV.
My HRV on Oura universally runs around 12 on oura. No matter what I do....so I choose to assume it's an error....like all my bad data.... don't tell me otherwise
I think the conflation of PRV and HRV is important to highlight, and you can certainly imagine anatomical or other reasons why the discrepancy between PRV and HRV would be bigger or smaller based on the individual.
If HRV is poor; it’s also reasonable to do a sleep study (home or lab PSG; single or multi night). I would suspect sleep architecture will be suboptimal.
I don’t recall seeing someone with suboptimal HRV and optimal sleep.
I stopped following mine. Too reactive
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The immune system offers a window into aging
The immune system permeates and regulates organs and tissues across the body, and has diverse roles beyond pathogen control, including in development, tissue homeostasis and repair. The reshaping of the immune system that occurs during aging is therefore highly consequential. In this Focus issue, Nature Aging presents a collection of reviews of and opinions on recent advances in research into immune aging. Nature Aging
Immune system influence on physiology
In this Review, we highlight recent studies that illustrate the often bidirectional and symbiotic relationships through which the immune system regulates physiology. Science
Pulse rate variability is not the same as heart rate variability
Scientists and consumer products are increasingly employing light-based photoplethysmography (PPG) instead of electrocardiography (ECG) assuming it accurately quantifies heart rate variability (HRV). Recent studies, however, have demonstrated that pulse rate variability (PRV) derived from PPG is not equivalent to HRV-derived from ECG. This study investigated the agreement between PPG-PRV and ECG-HRV in a beat-to-beat analysis in 931 adults recruited from a tertiary academic medical center in the southeastern United States. Frontiers Physiology
Every week, I track the biggest moves in longevity: new funding rounds, partnerships, product launches, and key hires.
Tony Robbins and Peter Diamandis’ longevity company Fountain Life raises $18M
Fountain Life, the longevity company co-founded by Peter Diamandis and Tony Robbins has raised $18M in a Series B, bringing total funding to $108M. Positioned at the high end of the market with memberships starting at $10,500 per year, Fountain Life operates four U.S. centers focused on early detection, biomarker optimization, and regenerative therapies, with expansion planned in Houston, Los Angeles, and Miami. TechCrunc
Whoop Won't Remove Its New Blood Pressure Tool Despite FDA Request
Whoop is facing regulatory heat after refusing an FDA request to remove its new blood pressure monitoring tool from the Whoop MG wearable. PCmag
Longer Leash On Life: Inside The Dog Longevity Startup
Loyal’s Celine Halioua has raised $135 million from top investors to develop canine longevity pills—and expects to get her first conditional approval from the FDA next year. Forbes
FDA approves breakthrough eye drops that fix near vision without glasses
The first aceclidine-based eye drop to improve near vision in adults with presbyopia, which affects more than 100 million adults in the US alone, has been approved by the Food and Drug Administration (FDA) and will be available within three months. NewAtlas
Every week, I comb through the mainstream headlines, handpick the most relevant longevity stories.
Ipsos Wellness Report 2025: How longevity, trust and cost will shape future care
Ipsos’s Wellness 2025 report paints a nuanced picture: Americans are optimistic about medical progress but anxious about rising costs. They value lifestyle—including diet and empowerment through data, yet remain cautious of AI and institutional trust. For the longevity industry, this spells opportunity: thoughtful, data-informed offerings will resonate deeply in this evolving wellness landscape. Ipsos
Chasing Longevity
Harvard Business Review’s Chasing Longevity explores the booming influence of longevity “gurus” shaping mainstream health culture. From Peter Attia’s Medicine 3.0 and “centenarian decathlon” framework, to Andrew Huberman’s neuroscience-driven podcast empire, and Eric Topol’s tech-fueled vision of AI and genetics, these voices are reframing how executives and affluent patients think about healthspan. HBR
Scientist Studied 4,330 Centenarians, Found Two Things They Have in Common
A new Swedish study analyzed over 4,300 centenarians and found they share two key traits: a resilient cardiovascular system and a positive outlook with a sense of purpose. Compared to peers, centenarians accumulated diseases more slowly, had fewer neuropsychiatric conditions, and often showed healthier biomarker patterns from as early as age 60. Newsweek
The ‘hair longevity’ trend is set to drive sales and innovation this year
The hair-care space is rapidly evolving as new technology and shifting consumer preference drive launches and sales. Glossy
Longevity Docs Peptides Mastermind
Join 100+ physicians at the first-ever Peptides Mastermind
📍 New York City | October 4, 2025 | Convene 101 Park
👥 In-person seats are highly limited to preserve depth, exclusivity, and real connection.
Longevity Conferences Calendar
ARDD: Copenhagen, August 25-29
Nubioage Clinical Longevity Summit: West Palm Beach, September 12-13, 2025
Longevity Investors Conference: Gstaad, Switzerland, September 22-25
Longevity Docs Peptides Mastermind: New York, October 4
Health Optimization Medicine Symposium: Boulder, October 17-18
Zenos Health Summit: Riyadh, October 23-25, 2025
Longevity Clinic Roundtable: Novato, December 6-8, 2025
A4M: Las Vegas, December 12-13
Longevity Docs Cannes: June 10-11, 2026
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
We’re not just witnessing the transformation of longevity medicine we’re building it. Together.
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.