Epic Lineup at the Longevity Docs Mastermind
Epic Lineup at the Longevity Docs Mastermind
Your sneak peek into the world of Longevity Docs.
Hi Longevity Docs,
From our humble beginnings with just a dozen physicians passionated about longevity medicine, we've grown into a global movement of over 200 dedicated docs across 40 countries. In 2 weeks, world-class physicians will meet for our bi-annual Mastermind in New York City.
This is the only gathering 100% dedicated to physicians — a unique opportunity to connect, learn, and shape the future of longevity medicine together.
Check out the impressive lineup we've prepared for you!
Wishing you an inspiring Sunday!
David
This week in our newsletter:
Community:
Discover the Speakers line-up
Introduction the Longevity Docs Collective
The reasons behind our brand refresh
Buzz in the Chat:
Protocol for dense breast tissue on mammograms?
Continuous Metabolic Monitoring?
FSA reimbursement for concierge fees?
Do you prescribe SGLTi as a longevity drug?
Publications:
The real-world safety profile of tirzepatide
Early-life risk factors for CIMT and carotid stiffness in adolescence
The LDL cumulative exposure hypothesis: evidence and practical applications
The role of colchicine in the management of COVID-19: a Meta-analysis
Lipoprotein(a) and cardiovascular disease
Press:
The Skeptic’s Guide to Red Light Therapy - GQ
Tony Robbins starts longevity clubs and hotels - Bloomberg
The new frontier of luxury travel is a $44,000 course of stem cells and a longevity club stocked with IV stations - Fortune Well
Canyon Ranch launches longevity retreat - Atheletech News
🚨 News
🎤 Longevity Docs Mastermind Speakers
Don’t miss your chance to connect with world-renowned longevity experts and gain exclusive access to cutting-edge insights—secure your spot now for 2 days of networking, learning, and collaboration within an elite community of physicians before tickets sell out!
✊ Introducing The Longevity Docs Collective
The Longevity Docs Collective is curated network of partners that gives Longevity Docs privileged access to the coolest, cutting-edge solutions in longevity. Think private invites to the hottest product launches, first dibs on partnership deals, and unique chances to test and tweak the latest breakthroughs. It's the ultimate hub for those looking to lead and redefine the future of longevity medicine.
Our first cohort of partners includes:
Timeline is committed to delivering clinically proven products to promote cellular rejuvenation and healthspan.
Marius Pharmaceuticals is paving the way for a new frontier in testosterone
Cellcolabs’ mission is to prevent and treat diseases by making high quality stem cells available and affordable
Nubioage is the leading cellular medicine platform
Human Longevity is the pioneer of longevity clinics
Generation Lab offers biological age for 19 different organs and systems
Nabla is the leading ambient AI assistant for clinicians
Extension Health is New York ultimate longevity destination
Hearty is the Longevity Medicine Platform for concierge doctors
Juisci is the AI-Companion for your Continuing Medical Education.
🎨 The reasons behind our brand refresh
When I first stepped into the world of medicine, everything around me was blue and white—the walls, the scrubs, even the branding. It was clean, clinical, and serious.
After all, healthcare should be serious, right? But as I progressed in my career, I began to feel that medicine could be more than just sterile walls and serious faces.
It could be human. It could inspire connection, collaboration, and innovation.
When I started Longevity Docs, I had one vision: to create a home for Longevity Medicine. A place where we’re not just advancing cutting-edge science and research but doing so with community and humanity at the core.
Our brand reflects this. The vibrant colors and sleek design represent the energy, warmth, and optimism that we bring to longevity medicine.
Medicine is not just about treating patients; it’s about creating a safe, supportive space where doctors, scientists, and innovators can grow, connect, and inspire each other.
At Longevity Docs, we want to be that space.
A home for those who believe in the future of health and wellness, for the next generation of doctors, researchers, and thinkers who are pushing the boundaries of what's possible.
We are committed to building a community that not only values the science but also the people behind it—the human element that drives us forward.
Our Longevity Docs Mastermind event this October will bring together leaders and pioneers in longevity medicine.
It’s a chance to connect, collaborate, and build something greater than ourselves.
A place where science, inspiration, and community intersect. We’re here to grow together, challenge the status quo, and inspire the next wave of innovation.
Thank you to the 200 doctors and partners supporting this vision. ❤️
💬 Buzz in the Chat
Radiologists/OB-GYNs friends: what's your protocol for dense breast tissue on mammograms? MRI or ultrasound?
Was the mammo performed with tomosynthesis? I usually start there.
not a specific patient. it is related to this: As of September 10, 2024, the Food and Drug Administration (FDA) requires that all mammogram reports sent to patients must include breast density, which should be described as either “not dense” or “dense.” Cancer.org
Use Tyler-Cuzick score to evaluate risk for cancer and recommend MRI based on score
Automated breast ultrasound is not nearly as effective as contrast MRI for imaging in patients with dense breast tissue. That said, a patient who is otherwise low risk (other than dense tissue) may not be interested in a yearly gadolinium contrast study.
Tyrer-Cuzick score is an easy-to-use calculator (but you’d need to know the patient’s breast density, as this is used in the calculation) A score over 20% is high risk and yearly MRI is warranted
I have also been more readily obtaining gene testing in any patient interested in testing or who I deem high risk. I’m finding many more mutations (CHEK2, PALB2, ATM as well as BRCA) than I would have anticipated (and these patients definitely need MRI and possibly risk-reducing surgery)
Yes i do the tyrer cruzial test and if they’re lifetime risk is above 20% or even borderline i set them up w high risk breast provider to get insurance to cover MRI. TC test takes like 5 min to calculate maybe 7 min. Breast density is def a risk factor and i have caught a lot of women who should have been getting MRIs who haven’t been
Continuous Metabolic Monitoring?: Veri has been acquired by OURA
Veri (pun intended) interesting! Thanks for sharing. Going head to head with Ultrahuman with ring/CGM.
It would be great to see continuous ketones and lactate, but I'll keep dreaming
Abbott are closer on lactate. Lactate much more difficult. Certainly many companies working on both. Some trying to combine sensors but have a feeling if we want all 3 we will be wearing 3 sensors
TMI - in spirit of Einstein, “keep it as simple as as possible, but not simpler”. Care on CGMs without DM. Better to help people learn how to make their lives as “no brainer” (default) healthy longevity and happiness promoting as possible. Imprecision nutrition? Duplicate meals result in unreliable individual glycemic responses measured by continuous glucose monitors across four dietary patterns in adults without diabetes
Is this a bug or feature?
I do think we have to be careful about this. Overall...use when can't figure out why cardiometabolic markers aren't budging. But our obsessions can lead to anxiety and craziness. Do not forget that happiness and social behaviors (like eating with friends and family) best predictor of longevity.
Goodhart’s law applies. But I think as a feedback tool with appropriate teaching they’re super powerful. Context matters though in use and in prescribing use.
The problem is reductionist product built on top of them. To say never spike is insanity.
While I don't trust CGMs so much any longer I'll bet they didn't control for light. Who was by window, who was outside, who was working on computer, what is maternal haplotype. Did they all wake up same time and sleep consistent.
Lingo is working on both of those last time I spoke to them.
I think they are good at giving directional information rather than 100% acurate blood sugar readings. In other words, seems to do a good job monitoring sugar spikes, and therefore which foods to avoid.
But you can’t base that choice on glucose alone. What might be better is a CMM (continuous metabolic monitor), including blood pressure (not very hard to argue substantially more important biomarker to have running data on vs continuous glucose monitor in the nondiabetic population), triglycerides (which often go hyper well before glucose) and if we’re talking about a non-diabetic population, insulin. But practically speaking, blood pressure is the most under monitored biomarker IMO, with clear path towards mortality and 25% of the population manifesting masked (opposite of white coat and therefore far more dangerous) hypertension. It’s perplexing to me that we have not perfected the scalable, continuous blood pressure monitor.
I’ve trailed the Aktiia and found it to be pretty good actually. Not perfect, but a huge step in the right direction for continuous BP
It doesn't matter how well it measures - is it actually of clinical utility to know somebodys BP readings all the time? All the guidelines and studies that I know of are only validated for resting BP. Are you using BP as a surrogate for other medical issues, like anxiety or stress or sympathetic-over drive? How does one treat "masked hypertension" without tanking their resting BP? I am still learning here.
I think that all of this will need to be extensively studied and figured out
Another use case is adjusting medication dosage (this is what I used it for personally) and it cut the trail time from months to weeks to figure out the right med and dose. Also I used standard BP to validate the readings and it was pretty close.
Does anyone have experience / perspective on getting concierge/clinic fees get reimbursed through FSA?
Yes. Per Jim Eischen (private direct medicine attorney from San Diego), as long as your contract/agreement is structured in a compliant manner … it’s up to the patient to check with their cpa/benefits plan manager, etc to determine if concierge services will qualify. This varies from plan to plan. If audited, the contract/agreement, etc is what would be used to justify the expense.
I would love to know if there is any specific language in the contract that is helpful to get the services covered by FSA .
Poll: Do you prescribe SGLTi as a longevity drug
🩺 Publications
Lipoprotein(a) and cardiovascular disease
The Lancet - Recommended by Dr. Neil Paulvin
This Review covers historical perspectives, physiology and pathophysiology, genetic evidence of causality, epidemiology, role in familial hypercholesterolaemia and diabetes, management, screening, diagnosis, measurement, prevention, and future lipoprotein(a)-lowering drugs.
The real-world safety profile of tirzepatide: pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
Journal of Endocrinological Investigation - Recommended by Dr. Frank Lipman
TZP was associated with an increased risk of specific AE. However, its safety profile was similar to that of GLP-1RA, without increased risk of pancreato-biliary AE, diabetic retinopathy, and medullary thyroid cancer.
Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence
JAMA Network - Recommended by Dr. Giovanni Campanile
The assessment of adipose tissue development during childhood can aid characterization of lifetime risk trajectories and tailoring of cardiovascular prevention and risk management strategies.
The LDL cumulative exposure hypothesis: evidence and practical applications
Cumulative exposure to LDL can be used as a biomarker to estimate the size of the accumulated plaque burden, track the rate of plaque progression and estimate the corresponding absolute risk of having an acute atherosclerotic cardiovascular event at any point in time.
Nature Reviews Cardiology - Recommended by Dr. Suwanna Suwannaphong
The role of colchicine in the management of COVID-19: a Meta-analysis
Colchicine caused a significant clinical improvement among COVID-19 patients as compared with the standard care or placebo, in terms of the need for O2, and mortality.
BMC Pulmonary Medicine - Recommended by Dr. Salome Mashgati
🌐 In the News
GQ: The Skeptic’s Guide to Red Light Therapy
Bloomberg: Sam Nazarian and Tony Robbins Are Launching Longevity Clubs and Hotels
Fortune Well: The new frontier of luxury travel is a $44,000 course of stem cells and a longevity club stocked with IV stations
Atheletech News: Canyon Ranch Launches Longevity Retreat at its Tuscon Resort
🤝 Job Board
The Mayo Clinic Florida is seeking a highly reputable, forward-thinking, and innovative Medical Director to lead the newly established Longevity Department at Mayo Clinic, Florida.
🗓️ Events & conferences
👉 Longevity Docs Mastermind: NYC - October 5,6
Biomarkers of Aging Conference - November 1-2, Boston, MA
A4M Fest - December 13-15, Las Vegas
Cannes Longevity Festival: Cannes, France - June 25,27 2025
About Longevity Docs Mastermind
The Longevity Docs Mastermind is a physician-only event focused on precision and evidence-based longevity medicine. This is where the medical leaders of today shape the future of longevity.
New York City - October 5-6, 2024
Convene 101 Park Avenue, NYC