Checklist for Longevity Docs • PRP Dilemma • Urolithine A Masterclass • Peloton’s Longevity Play
Issue 47: The front page of longevity medicine - curated by doctors, for doctors.
On Friday, we had the honor of hosting Dr. Eric Verdin, President of the Buck Institute, for our monthly Longevity Docs Club Forum. It was an intimate and powerful session with 20 members, focused on the state of longevity medicine today—and where it’s headed next.
Eric reminded us of something essential: longevity medicine must be grounded in science, precision, and purpose. From insulin signaling to digital twins, we explored the balance between emerging therapies and what already works. The session sparked something for me.
I kept thinking: with all this change, what should every longevity doctor really know?
That’s what inspired this week’s cover story: The Longevity Docs Checklist: 10 things every serious longevity physician needs to build a practice that lasts and lead this movement with integrity.
Let’s raise the standard. The future of longevity medicine depends on it.
Happy Sunday!!!!
In this week’s newsletter:
Cover Story
The Longevity Docs Checklist
Inside Longevity Docs
Eric Verdin on defining the field.
Naveen Jain on thinking like a tech founder.
Elizabeth Yurth on why cellular optimization matters now.
Buzz in the Chat
PRP kit wars: cost, quality, and the call for standardization.
Evidence-Based Longevity
Microbiome, aging clocks, stem cells: what the latest research means for your practice.
Business of Longevity
OpenAI, Peloton, Estée Lauder…everyone’s entering the longevity game.
Community Wire
Dr. Melissa Loseke is pioneering cellular and hormonal health in the Midwest.
Longevity Docs Calendar
May 23: Urolithin A Masterclass (virtual)
June 25–26: Cannes Longevity Summit
The Longevity Docs Checklist
10 must-haves to lead the future of medicine
After meeting over 400 doctors from around the world, I’ve realized there’s no one-size-fits-all approach to practicing longevity medicine. Every doctor brings a different background, patient base, and clinical focus. That’s why I believe more in frameworks than rigid guidelines.
Longevity Docs are the trendsetters the ones pushing medicine forward before the institutions catch up. But even pioneers need the right backpack, roadmap, and team to begin the adventure.
And funny enough patients are starting to evaluate longevity doctors the same way. They’re looking for more than a white coat. They want proof, personality, purpose, and a plan.
So I thought I’d share the 10 most common things doctors need -universally- when stepping into longevity medicine. Consider this your essential checklist to build a practice that lasts:
1. Longevity science knowledge: master the fundamentals of aging biology, diagnostics, and emerging therapeutics, because protocols without understanding won’t get you far.
2. Real-world outcomes tracker: from biomarkers to functional capacity, track what matters. You can’t improve what you don’t measure.
3. Local community: surround yourself with allies (trainers, chefs, therapists) who reinforce daily longevity habits outside the clinic.
4. Global network of doctors: stay tapped into what’s working globally. Your next breakthrough may come from a peer in Singapore, Paris, or São Paulo.
5. Vetted clinical partners: don’t recommend what you haven’t tested and audited. Work with labs and therapeutics that are trusted and clinically validated
6. Tech and AI stack: automate the admin, personalize the care. Let tech do the grunt work so you can focus on impact.
7. Educational content: patients follow when they understand the why. Be the translator of science, not just the messenger.
8. A personal manifesto: let your values show. You’re not just selling protocols, you’re building trust, leadership, and a legacy.
9. Operational infrastructure: your practice should work for you, not the other way around. Build systems to grow without burnout.
10. Your own longevity plan: Live it. Share it. Patients can tell when you walk the talk and it changes everything.
This is not an exhaustive list, but if you’re missing even one, now’s the time to level up.This field is moving fast and only the most prepared will define what comes next.
Longevity is not just a specialty. It’s a movement.
And movements need leaders who are all in.
Summit Speakers Announcement
What Is Longevity Medicine — and What Should It Not Be?
Eric Verdin, MD | CEO, Buck Institute for Research on Aging – USA
Opening Keynote
As breakthroughs in aging biology and translational research accelerate, longevity medicine is emerging as a new paradigm in care — but without a clear definition, it risks dilution.
In this opening keynote, Dr. Eric Verdin sets the stage with a critical question: What is longevity medicine — and what must it not become? Grounded in rigorous science and clinical data, he outlines the non-negotiables for physicians leading this field: evidence-based interventions, responsible innovation, and a commitment to education. This is a call to protect the integrity of the field while boldly advancing it.
Think Like a Longevity Tech Unicorn
Naveen Jain | CEO, Viome – USA
David Luu, MD | Founder, Longevity Docs – USA
Fireside Chat
How Physicians Can Build Scalable, High-Impact Longevity Clinics
Visionary entrepreneur Naveen Jain, founder of Viome, joins Dr. David Luu for an unfiltered conversation on how physicians can think bigger — like tech founders. This session explores how to build clinics that scale, brands that resonate, and missions that attract capital and talent. Learn how to combine clinical excellence with platform thinking to lead the future of personalized, precision-based longevity care.
Cellular Optimization: Is It the Future of Medicine?
Elizabeth Yurth, MD | Co-Founder, Boulder Longevity Institute – USA
Expert Talk
How Mitochondria, Biological Aging, and Cellular Repair Are Changing Clinical Practice
Dr. Elizabeth Yurth, a pioneer in regenerative and performance medicine, dives into the cellular revolution reshaping clinical protocols. Learn how interventions targeting mitochondrial health, cellular senescence, and biological age are transforming outcomes in energy, recovery, and age-related decline. Get practical insights on how to bring cellular optimization into your own practice — and why it may soon become the foundation of 21st-century medicine.
Join us in Cannes on June 25-26 to learn and connect with the world’s leading longevity doctors and leaders.
The PRP Kit Dilemma
In regenerative medicine, one challenge keeps resurfacing: the cost, quality, and credibility of PRP kits.
This week, Longevity Docs voiced growing frustration—from rising prices to patient confusion.
“I use 4 Emcyte kits per case. Concentration matters—but people don’t understand why PRP is expensive.” – Dr. SM
“Alex Biologix kits are now $250. It’s painful.” – Dr. AK
“We need head-to-head trials and group discounts, like SSRP does.” – Dr. ML“The data for now shows 1) concentration and counts matter. Need to be in billions, often 10x or more concentration 2) Orthopedic indications have been studied most and routinely fail when less that 1x or 3+ billion platelets per injection 3) cost vs quality will be an issue until we can assure sterility and safety in manual prep. 4) the only way to absolutely assure outcome is to be able to measure levels” - Dr. SM https://pubmed.ncbi.nlm.nih.gov/39318712/
Clinical Question: Can physicians deliver quality outcomes while navigating PRP kit costs—and educating patients on what real, evidence-based PRP entails?
Why it matters: The best outcomes rely on high platelet concentrations, validated protocols, and skilled delivery—often using premium kits like Emcyte or Apex. Yet price pressure is growing, with some doctors blocking out entire days to do it right.
What to watch: Expect a shift toward group-negotiated pricing, standardized kit comparisons, and published data on platelet yield and efficacy.
Bottom Line: PRP has the strongest evidence in orthopedics and aesthetics. For longevity, it demands clinical rigor. Longevity Docs must be trained in the underlying science, technology, and risks—because evidence-based practice is what will set real medicine apart from hype.
How can Longevity Docs help patients taper off benzodiazepines and manage anxiety using next-generation tools
Benzodiazepine dependency is notoriously hard to treat. Traditional tapers often fail without neuroregenerative support. Longevity Docs are experimenting with GLP-1s, Selank, NAD+, LDN, breathwork, acupuncture, and microdosing to bridge the gap, bringing a new, multidisciplinary lens to anxiety, addiction, and brain health.
“GLP-1 has been much better than NAD. It sounds crazy, but it breaks dependence and tolerance much more effectively.” – Dr. SM
“Selank all the way… I’ve had success with injections.” – Dr. MM
“I'd recommend the Stamet Stack:psilocybin, lion’s mane, niacin. Helps anxiety and depression, early neuroprotection too.” – Dr. GG
What to Watch:
GLP-1s (Semaglutide/Tirzepatide) for rewiring addiction behavior
Selank (nasal vs. IM): emerging as a safe, non-sedating alternative
Low Dose Naltrexone (LDN): for autonomic stabilization and mood regulation
Adjunctive therapies: acupuncture, vagus nerve stimulation, float therapy
Microdosing: Psilocybin stacks used cautiously, especially in “euphoria-naive” patients
Bottom Line: This evolving toolkit reflects the future of evidence-based psychiatry. But without standardized protocols, outcome tracking, and education, these interventions risk being dismissed. Longevity Docs must lead with science, transparency, and patient safety.
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This week’s new members
Every week, I personally onboard the next generation of longevity leaders.
From all over the world, these exceptional doctors are joining the Longevity Docs community, each bringing deep clinical experience, entrepreneurial spirit, and a shared mission to extend human healthspan. Welcome to our newest members. We’re building the future of longevity medicine together.
Dr. Sonya Pease, MD
West Palm Beach, FL – Anesthesiologist & Longevity Program Lead, Cleveland Clinic Florida
“We’re launching more than a wellness program — we’re laying the foundation for Cleveland Clinic’s next chapter in prevention.”
Sonya is bridging her expertise in anesthesiology, wound healing, and recovery optimization to lead Cleveland Clinic Florida’s forthcoming wellness and longevity center. Drawing on her experience with CMS quality measures and care episodes, she’s designing a future-forward clinical model that moves medicine upstream. As she explores expanding into longevity medicine, Sonya joins the Longevity Docs circle to connect with fellow pioneers driving real change — from clinical innovation to systems transformation.
Dr. Ryan McCarty, MD
Los Angeles, CA – PM&R, Pain Specialist
“Longevity medicine is underserved in LA — I see a chance to fill that gap with clinical depth and data.”
Ryan is an LA-based physician combining pain management, PM&R, and cutting-edge therapies like GLP-1 to build a new kind of private practice. As adjunct faculty at UCLA and a leader at the West LA VA, he brings both academic rigor and frontline experience. With demand for longevity medicine surging and qualified supply lagging, Ryan is stepping in — with plans to integrate biomarker-driven care, real-world outcomes, and scalable clinical models. He joins Longevity Docs to build, learn, and lead.
Dr. Naana Boakye, MD
Hackensack, NJ – Dermatologist & Founder, Lifestyle Dermatology
“My patients aren’t just asking for better skin — they’re asking how to live longer, healthier lives.”
Naana is a solo dermatologist redefining beauty through a longevity lens. At her practice in New Jersey, she pioneered a lifestyle dermatology model that merges clinical skin health with scientific, personalized wellness. As patient demand expands beyond aesthetics into prevention, hormones, and holistic care, Naana joins Longevity Docs to integrate biomarker-driven protocols into her clinical flow — and help shape the future of beauty and health.
Dr. Sarah Lacarrubba, DO
Connecticut – Family Medicine & Founder, Longevity Practice (Launching 2025)
“Longevity care is no longer optional — it’s what patients want and medicine needs.”
Sarah is building Connecticut’s next premier longevity clinic. A family medicine physician with roots in urgent care and aesthetics, she’s now turning her full attention to precision testing, hormone optimization, and science-backed interventions. As a soon-to-launch clinic founder, she joins Longevity Docs to surround herself with the right peers, plug into community support, and make sure her patients benefit from the best in evidence-based longevity.
Dr. Niki Panich, MD, MBA
California – Women’s Health Physician & Longevity Strategist
“Women’s health and longevity aren’t separate fields — they’re the same story told deeper.”
Niki brings a powerful trifecta to longevity medicine: clinical care in women's health, business leadership from Stanford, and an AI master's lens on future health systems. With patients asking for hormone support and prevention strategies, she’s exploring how to bring the full spectrum of longevity care into her work — from data-driven interventions to patient education. Niki joins Longevity Docs to be part of the movement building this new paradigm from the inside out.
Dr. Rishi Khakhkhar, MD
New York City – ER Physician & Healthtech Founder, Council Health
“Longevity is the logical next step for medicine — and tech can help make it accessible.”
Rishi is an emergency physician and founder of Council Health, an AI-enabled asynchronous care platform. From zone 2 cardio to ApoB tracking, his personal longevity journey now fuels a professional one. With roots at Mount Sinai and a passion for real-world implementation, Rishi is exploring how longevity can integrate into tech-forward primary care. He joins Longevity Docs to get clinical grounding, expand his network, and help bring prevention mainstream.
Dr. Sarvin Radvar, MD
Tehran, Iran – Physician-Researcher & Founder, Sarvin Longevity
“Longevity isn’t just about aesthetics or lifespan — it’s about scientific precision for human flourishing.”
With deep roots in neuroscience, cardiometabolic aging, and aesthetic rejuvenation, Sarvin brings a rare blend of bench science and clinical artistry. From pioneering research on NMN and melatonin to hands-on work with skin boosters and threads, she’s building a bridge between cellular health and patient outcomes. Now founder of Sarvin Longevity, she joins the Longevity Docs network to connect with global peers and help shape the scientific foundations of longevity medicine — especially in underserved regions like Iran.
Dr. Maritere Rochet, MD
Puerto Rico – Lifestyle Medicine
“We don’t have time to wait for institutions to catch up — the world needs better medicine now.”
Maritere is on a mission to transform care in Puerto Rico and beyond. With a firm belief that prevention, optimization, and education must lead the next era of medicine, she’s diving into longevity with purpose.
Dr. Ambrosio Claud Jumangit III, MD
Manila, Philippines – Medical Director , Longevity Center Philippines
“We’re building a $50 million hub — not just for wellness, but for the future of medicine.”
Ambrosio brings nearly two decades of clinical research and lifestyle medicine leadership to the forefront of a new era in Asia. As Medical Director at Thermo Fisher and a leading force behind a multi-million-dollar longevity center, he’s fusing red light, gene therapy, IVs, and culinary medicine into a future-ready clinic. Now aligned with Longevity Docs, he seeks to elevate his vision with global protocols, peer collaboration, and physician education.
Private Club Spotlight
Meet the Longevity Doctors Club members: physicians entrepreneurs building the future of longevity medicine one practice (or more) at the time.
Melissa Loseke, DO
Founder of Re-new Institute
Dr. Melissa Loseke is an innovator in anti-aging and regenerative medicine, specializing in peptide therapy, cellular repair, hormone optimization, aesthetics, and joint repair. She is widely regarded as an expert in women’s and men’s hormonal and sexual health and delivers highly personalized, patient-centric care at Re-New Institute in Omaha, Nebraska.
Her path to medicine began early—Dr. Loseke knew she wanted to be a doctor since she was a child. Raised in small-town Columbus, Nebraska, her values of hard work and service still guide her practice. After earning her B.S. in Biology from Nebraska Wesleyan and her Doctorate of Osteopathic Medicine from Des Moines University in 2006, she completed her Family Medicine residency at the University of Nebraska Medical Center.
She has led clinical teams across specialties—from family medicine to joint regeneration and hormone health. As Nebraska’s first certified peptide therapy physician and its only SSRP Fellow in cellular medicine, Dr. Loseke integrates cutting-edge protocols including PRP, stem cells, and low-level laser therapy.
Dr. Loseke embodies the next-gen longevity physician—clinically grounded, relentlessly innovative, and actively shaping best practices in hormonal, regenerative, and aesthetic longevity.
📍 Omaha - Nebraska, USA | Re-new Institute
Join the Longevity Docs Club
If you’re a physician starting or scaling your longevity practice highly vetted Longevity Docs Club is for you.
Join a community of like-minded physicians and gain access to resources on marketing, finance, strategy, and technology to support your independent practice
Applications now open for MD, DO, or MBBS - Limited memberships
Longevity Docs Around the World
The gut microbiota and aging: interactions, implications, and interventions
This review consolidates emerging evidence on how shifts in the gut microbiome drive inflammaging, metabolic drift, and cognitive decline — and outlines targeted interventions including dietary polyphenols, pre/probiotics, and even fecal microbiota transplantation (FMT). For longevity-focused physicians, the microbiome is no longer a niche topic — it’s a frontline biomarker and therapeutic target, especially in immunosenescence and cardiometabolic health. It’s time to standardize microbiome testing and consider how to build longitudinal microbiome monitoring into your protocol stack. Frontiers in Aging
Biological clock based on blood measurements predicts mouse lifespan and frailty
This preclinical study introduces a simplified blood-based algorithm for predicting lifespan and frailty in mice — an analog to the human “aging clocks” now entering clinics. The implication? Expect new, lower-cost, panel-based clocks to emerge for human use — not just for research, but for real-time patient tracking. Doctors should be preparing to interpret, validate, and integrate biological age data as a core longitudinal metric in their practices. National Institute on Aging
Economic impact of biomarker-based aging interventions on healthcare costs and individual value
A new study using the DunedinPACE epigenetic clock shows that slowing the pace of aging from age 50 can reduce frailty and save up to CHF 131,608 per person in healthcare costs over 40 years. From an individual's perspective, the willingness to pay for such interventions—factoring in longer life and better health—could reach CHF 6.7 million. This reinforces the economic case for biological age testing and personalized interventions—providing doctors with powerful arguments to adopt and advocate longevity medicine in both clinical and consumer contexts. arXiv
Stem cell therapies for Parkinson’s disease
A new round of promising data shows stem cell-derived dopaminergic neurons reversing symptoms in Parkinsonian models. While clinical use remains limited, the pipeline is rapidly maturing. This is your signal to monitor cell therapy vendors, regulatory approvals, and ethical considerations — especially for neurodegenerative and frailty-related conditions in your aging patients. Nature Aging
We track the week’s most strategic moves in innovation, funding, product launches, and talent shifts. This is not just to report them, but to help doctors stay informed, ahead, and equipped to adapt as the field evolves.
Because the future of longevity medicine is being built in real time and you deserve a front-row seat.
FDA Approves First Blood Test for Alzheimer’s Diagnosis
The Lumipulse G pTau217/ß-Amyloid 1-42 Plasma Ratio has become the first FDA-cleared blood-based test to detect amyloid plaques linked to Alzheimer’s in symptomatic adults aged 55+. It offers a high predictive value (91.7% positive, 97.3% negative) and reduces the need for PET scans or CSF analysis.
Why it matters: This test marks a turning point in early neurodegenerative diagnosis—enabling earlier intervention and more accessible care pathways. Longevity physicians can now integrate blood-based cognitive risk assessments into proactive aging protocols.
OpenAI + Retro Biosciences: Cellular Reprogramming Boost
OpenAI and Retro Biosciences announced an AI breakthrough that improves cellular rejuvenation efficiency by 50x using advanced protein engineering.
Why it matters: Doctors need to track how AI is accelerating translational aging science—this could fast-track clinical applications in reprogramming.
Somite AI Raises $47M To Reinvent Cell Replacement Therapy
Somite AI secured $47M to advance its regenerative AI platform for tissue repair and aging reversal.
Why it matters: New funding signals growing investor confidence in tech-powered longevity solutions—physicians should watch for clinical integration potential.
OpenAI Launches HealthBench
HealthBench is a new benchmark to evaluate AI model performance in real-world clinical scenarios, developed with 262 doctors from 60 countries.
Why it matters: AI is entering the clinical room—HealthBench helps doctors assess which tools to trust in their practice.
Peloton Adds Longevity Classes
Peloton launched three Longevity classes (Strength + Mobility), designed for functional movement and connection across generations.
Why it matters: Longevity is reaching the mainstream. Doctors should leverage this trend to recommend accessible, movement-based protocols.
Estée Lauder Opens Skin Longevity Institute in Costa Rica
The first Estée Lauder Skin Longevity Institute opens in a Blue Zone-adjacent wellness resort, offering anti-aging facials and expert residencies.
Why it matters: Skin health is becoming a visible entry point into longevity. Physicians should expect more patient interest in aesthetic-aging synergy.
🚨 Longevity Docs Exclusive Masterclass
Urolithin A: The Science Behind Mitochondrial Optimization
📅 May 23rd | 💻 Virtual
Join us for an unmissable masterclass with Dr. Anurag Singh, MD PhD, Chief Medical Officer at Timeline, the pioneer behind Urolithin A and Mitopure.
If you're a physician serious about integrating mitochondrial science into your protocols, this is the clinical deep dive you’ve been waiting for.
What you’ll learn:
The real science behind Urolithin A and mitophagy
Latest clinical trial data on aging, muscle, and metabolic health
How to apply this compound in evidence-based longevity care
Seats are limited to physicians
Secure your spot now and stay ahead of the curve.
Longevity Docs Summit Cannes
This is not just another medical conference, this is the future of cutting-edge longevity medicine.
Join the world’s most visionary longevity physicians, scientists, and innovators for two days of breakthroughs, discoveries, and high-level networking under the French Riviera sun.
Summit. Awards & Black tie Gala. Expo.
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
🎟️ Registrations are now open: and spots are limited.
👉 Apply now before it sells out. The New Gods of Medicine will be in Cannes. Will you?
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Longevity Conferences Calendar
Xprize Healthspan NYC - May 12-13
Life Summit - Berlin, May 27-28
Dublin Longevity Summit: Dublin, July 2–4
ARDD: Coppenhagen, August 25-29
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
Subscribe to the Longevity Docs Newsletter
Stay connected with the backstage of the Longevity Docs community, a network of over 400 physicians spanning 50 countries, united in our mission to democratize longevity medicine. Explore the latest in evidence-based longevity care, gain exclusive access to physician insights, and join us in shaping the future of this transformative field.
Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.