Announcing the Longevity Docs Institute | Plasmalogenes, C15:0 deficiency

Your sneak peek into the world of Longevity Docs.

Jun 30, 2024

Hey Doc, do you remember the day you swore the Hippocratic Oath?

As physicians, we have a responsibility, inspired by Hippocrates, the Father of Medicine, who laid the scientific foundation for medicine 2,400 years ago, freeing it from superstition and philosophy.

Today, in this exciting era of Longevity Medicine, we must ensure we protect patients and uphold the key principles of the Hippocratic Oath: prioritizing patient safety, maintaining integrity in our work, and sharing knowledge with future generations.

Our mission has shifted from just treating the sick to improving everyone's healthspan.

Imagine a world where innovative tests, treatments, and procedures are proven safe and cost-efficient for each patient without decades of research.

That's why we created the Longevity Docs Institute—a physician-led, decentralized research platform enabling real-world evidence and N-of-1 research for all physicians.

Welcome to the era of precision longevity medicine.

David

🚨 Longevity Docs News

🧬 Longevity Docs Institute created to advance precision and evidence-based longevity medicine.

Together we can revolutionize longevity medicine through innovative, decentralized studies. If you’re a longevity-focused physician eager to collaborate on patient registries and publish groundbreaking research, apply to join the institute:

Join The Institute Waitlist

👋 Community: Welcome to our new members

Kyle Gillet, MD - Kansas City, KS, USA
Jennifer Phelps, MD - Redding, CT, USA
Philip Borg, MD - Manchester, UK
Cother Hajat, MD - Oxford, UK
James Salway, MD - New York, NY, USA
Mark Jinks, MD - London, UK
Adam Brown, MD - Sidney, Australia
Susan Flanzman, MD - Paramus, NJ, USA
Sanjay Raisoni, MD - San Francisco, CA, USA

Apply here to become a member.

🎤 Events

🇺🇸 Mastermind - NYC, October 5-6, 2024

The Longevity Docs Mastermind is a physician-only event focused on precision and evidence-based longevity medicine.

Early-bird ticket - Limited to 50

🇫🇷 Cannes Longevity Festival, June 25-27, 2024

Join us June 25-27, 2025, at the iconic Palais des Festivals in Cannes to shape the future of longevity medicine!

Join the Waitlist

📊 Poll

Would you offer your expertise as an advisor to companies? If yes, which types of companies would you be willing to advise?

Discover how physicians are keen to offer their insights across various industries, from tech startups to fitness and wellness, shaping the future of health and longevity.

💬 Buzz in the Chat

Have you ever heard of C15:0 deficiency?

I was very skeptical of fatty 15 when I first heard of them. I thought it was a gimmick. But then I went to see my integrative cardiologist and he told me he's been seeing patients have lower cholesterol on it. I just finished my first bottle. I plan to do follow-up blood tests in a couple weeks to see if it actually has any impact on my blood lipids
Dr Goodenowe who is one of the smartest lipid biochemists I know is not a believer in pentadecanoic acid as anything essential. Hard to figure this all out!!! C17 maybe better but 🤷‍♂️. I've been using it in myself and my patients at all sorts of doses since they first came out cause i was really compelled by Stephanie'sresearch. Don't know if I have seen much marked changes, is pricey. At this point I don't know the answer
I tried plasmalogens from Prodrome at high doses for a couple months. I tried both kinds. It had no effect on anything I could easily measure or feel.
I use lots of plasmalogens. Game changer in your neuro patients. I notice my vision is better with high dose glia
I know you’ve been a proponent of Fatty 15. May I ask what changed?
I'm still using and recommending for now. But like everything I do, when I get new info I have to rethink. I don't yet know the answer here. Have to spend more time researching it and getting info. The hard thing about our world!! Gotta keep learning and changing!!
Yeah. I can't say that I have ever taken a supplement that I found to be a game changer in my life. I do lots of things... like plasmalogens to prevent future problems
Love that, I think exactly the same! Something that people struggle to integrate… prevention and optimization…
What specifically are you hoping to prevent?
Cognitive decline, brain volume loss, sarcopenia, vision and hearing deterioration
Fascinating-/ what measures have you seen since introducing?
Increased brain volume on functional mri on plasmalogens... which dr Goodenowe has lots of evidence of. Pretty impressive

🩺 Publications

Ezetimibe lowers risk of Alzheimer’s and Related Dementias over 7-fold, reducing aggregation in model systems by inhibiting 14-3-3G::hexokinase interaction

These results suggest that drug disruption of the 14-3-3G::HK1 interface blocks an early “lynchpin” adhesion, prospectively reducing aggregate accrual and progression of Alzheimer’s disease and related dementias.

Aging Biology - Recommended by Dr. Sajad Zalzala

Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer’s disease assessment

High-throughput plasma Aβ42/40 LC-MS/MS assays can help identify patients with low likelihood of AD pathology, which can reduce PET evaluations, allowing for cost savings.

Frontiers - Recommended by Dr. Robin Rose

Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants

Higher MDS levels independently predict an elevated risk of mortality among US adults with HTN. Therefore, MDS may serve as a cost-effective and widely available prognostic marker for HTN.

Biological Trace Research Element - Recommended by Dr. David Luu

The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets

The Lipid Energy Model (LEM) attempts to explain this metabolic phenomenon by positing that, with carbohydrate restriction in lean persons, the increased dependence on fat as a metabolic substrate drives increased hepatic secretion and peripheral uptake of TG contained within very low-density lipoproteins (VLDL) by lipoprotein lipase, resulting in marked elevations of LDL-C and HDL-C, and low TG.

Metabolites - Recommended by Dr. Guenole Addor

Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim

Here, Nicotinamide mononucleotide and Urolithin A supplements, easily accessible online or in pharmacies, were tested for their active ingredient content. Results showed a significant deviation from the labeled amounts, ranging from + 28.6% to -100%. This indicates a considerable disparity in the quality of geroprotective supplements.

Geroscience - Recommended by Cother Hajat

🗓️ Events & conferences

👉 Longevity Docs Mastermind: NYC - October 5,6
LiveLong Summit: Los Angeles - August 3,4
ARDD: Copenhagen, Denmark - August 26,30
Cannes Longevity Festival: Cannes, France - June 25,27 2025

About Longevity Docs

Longevity Docs is a highly-vetted membership network dedicated to physicians pioneering precision and evidence-based practices in longevity medicine.

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