Aging hits us in our 40s and 60s ⎮HBOT ⎮The Galleri Promise ⎮Meet Dr. Robin Rose
Aging hits us in our 40s and 60s ⎮HBOT ⎮The Galleri Promise ⎮Meet Dr. Robin Rose
Your sneak peek into the world of Longevity Docs.
Hey Docs, this week in the Longevity Docs Newsletter:
Buzz in the Chat: HBOT and Galleri
Meet our Mastermind speaker Dr. Robin Rose
Publications: Proteomic aging signatures, mild hyperbaric oxygen exposure protects heart, Nonlinear dynamics of multi-omics profiles during human aging
Press: Aging hits us in our 40s and 60s
Looking forward to seeing you all in New York, October 5th.
Happy Sunday!
David Luu
🚨 Longevity Docs News
👋 Community: Welcome to our new members
Palak Majmudar: Shaumburg, IL -USA
Jorge Perez: Miami, FL
Charles Pereyra: San Diego, CA
Admir Hadzic: Genk, Belgium
Jorge Monteiro: Porto, Portugal
Shoma Datta-Thomas: New York, NY
Anand Patel: Shaumburg, IL -USA
Radovan Hnatic: Prague, Croatia
Robert Jarema: Warsaw, Poland
Anders Kassem: Kastrup, Copenhagen
🎤 Dr. Robin Rose will speak at the Longevity Docs Mastermind NYC on October 5-6
Dr. Robin Rose, author of “The 28-Day Gut Fix,” is a double board-certified specialist in Gastroenterology and Internal Medicine, specializing in gut health and Long COVID. She is founder and CEO of Terrain Health where she practices next-generation precision healthcare, integrating systems biology with an innovative approach that requires a deep understanding of each person’s biochemical, genetic, and lifestyle factors.
Dr. Robin received her bachelor’s degree in Behavioral Neuroscience from Lehigh University, graduating with honors. She then went on to obtain her master’s degree in Neuropsychology from New York University. Dr. Robin received her medical degree from the New York College of Osteopathic Medicine, graduating with honors, and was inducted into the Psi Sigma Alpha Osteopathic National Honors Society.
She did her post-graduate training in Internal Medicine, Gastroenterology & Hepatology at Beth Israel Medical Center in New York City and received board certification in both disciplines. Dr. Robin is listed as a functional medicine provider with the Institute of Functional Medicine. Dr. Robin teaches women and men how to achieve their best selves by restoring and optimizing gut health. Attaining gut balance impacts our brain, hormone, metabolic, and skin health, paving the way for feeling more energized and looking and feeling your best.
💬 Buzz in the Chat
Galleri promises to detect multiple cancers—but new evidence casts doubt on this much hyped blood test
The bad press builds. I wonder how many patients who paid >1k for this test feel reading this. Has anyone talked to their rep lately?
Yeah, I think tests based on circulating tumor cells, cell fragments, or cf-DNA are a dead-end. Its a numbers game. In order to detect any sort of signal from these in 2 or 3 small tubes of blood, there needs to be an existing tumor "burden" sufficient enough to generate such signals.
More promising tests seem to be looking for protein or mRNA or stem-cell signals that are NOT dependent on tumor burden, rather look for other patterns that indicate a "tumorgenic" environment.
There is a Canadian company called Stage Zero Life Science (SZLS) that developed a multi-cancer detection test based on mRNA signals. Its a promising test, but mRNA has proven to be too unstable for large-scale roll out. My favorite so far is the India-based Tzar Labs.
I remember talking to them about three years ago. Really cool stuff they're doing. I'd love to see it in the US
Agreed. I think I’ve posted here before about how the Gallieri has unimpressive test performance. I like the datar tests the best. But gallieri has far and a way best mindshare due to superior marketing and distribution. That stuff always carries the day over science unfortunately
I have a patient who uses HBOT at home and was asking if it makes a difference taking antioxidant boosting supplements around the HBOT?
Most will not need exogenous anti-inflammatory. In fact, it’s probably detrimental to achieving the desired effect. HBOT works by increasing oxidative stress via increase in cellular respiration which will increase superoxide. This allows for the desired DNA repair, stem cell release, and decrease in inflammatory cytokines.
When HBOT is administered properly (dose matters) the body will ramp up its own antioxidants including superoxide dismutase. It’s all about balancing oxidative stress. Unfortunately, when exposed to external oxidative stress such as smoke, toxins etc. – we do not have a mechanism to ramp up our internal antioxidants – hence the requirements for exogenous antioxidants.
Agree with A., the short answer is not recommended to take extra antioxidants around HBOT unless antioxidant deficiencies are present. Here is a great paper on what A. described by Dom D’Agostino and colleagues.
In essence oxidation is the engine of how HBOT works under many circumstances but not all. There’s also oxygen delivery and pressure ongoing too during treatment. However, in our sicker patients who cannot mount their own antioxidant response, we can potentially use them. My sense is that for many of these patients, it would initially be better to NOT do hbot until they were supported rather than going directly into this chamber unless there was an acute need! This gets me in trouble in the hbot community sometimes but I don’t mind :)
🩺 Publications
Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study
The Lancet - Recommended by Dr. Guenole Addor
Galleri promises to detect multiple cancers—but new evidence casts doubt on this much hyped blood test
BMJ Investigation - Recommended by Dr. Jonathann Kuo
Proteomic aging signatures predict disease risk and mortality across diverse populations
Nature - Recommended by Dr. David Luu
Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice
Cellular Reprograming - Recommended by Dr. Steven Murphy
Mild hyperbaric oxygen exposure protects heart during ischemia/ reperfusion and affects vascular relaxation
Cell - Recommended by Dr. Giovanni Campanile
Nonlinear dynamics of multi-omics profiles during human aging
Nature Aging - Recommended by Dr. David Luu
🌐 In the News
Aging hits us in our 40s and 60s. But well-being doesn’t have to fall off a cliff.
The Uncertain Path Forward for Psychedelic Medicine
🗓️ Events & conferences
👉 Longevity Docs Mastermind: NYC - October 5,6
ARDD: Copenhagen, Denmark - August 26,30
RAAD Festival - Anaheim CA - September 5-8
Peptide Therapy Certification - September 6-7, Orlando, FL
Cannes Longevity Festival: Cannes, France - June 25,27 2025
About Longevity Docs Mastermind
The Longevity Docs Mastermind is a physician-only event focused on precision and evidence-based longevity medicine. This is where the medical leaders of today shape the future of longevity.
New York City - October 5-6, 2024
Convene 101 Park Avenue, NYC