50¢-a-Day Longevity Promise• Tau Biomarkers Staging • Hijacked Men’s Wellness • Wegovy & MASH
Issue 59: The front page of longevity medicine - curated by doctors, for doctors.
Hey Doc,
In a few hours, I’ll be speaking on a panel at the Milken Institute in the Hamptons about one of the subjects closest to my heart: longevity. Most of the sessions here are under Chatham House rules (no photos, no quotes) but what I can share is how deeply impressed I am by the focus on health innovation and longevity.
As physicians, it’s not always easy to step outside our daily practice and see the bigger picture. Yet these conversations remind me why it matters. I’m grateful for the opportunity to represent Longevity Docs at the Milken Institute and to push forward our mission: democratizing longevity medicine.
In this week newsletter:
Buzz in the Chat: What are your thoughts about doing TKA (Total Knee Arthroplasty) on a 90 year old woman?
Cover Story: 50¢-a-Day Longevity Promise
Research Radar: Tau biomarkers staging • Rejuvenation of Senescent Cells • COVID-19 and accelerated vascular ageing
Longevity in the News: How ‘Optimisation’ Hijacked Men’s Wellness • The Era of Longevity Travel • 2 anti-aging pills? • Can We Beat Cancer?
Longevity Intelligence: $199 Superpower Labs •Eight Sleep Secures $100 Million • GLP-1 drug Wegovy to treat MASH
Healthy Sunday!
Always inspired by this view 🌊
Our team is hard at work, and I’m excited to share what’s happening behind the scenes across the Longevity Docs ecosystem.
Education: our Longevity Medicine Certification is moving forward with the CME process through ACCME accreditation. Unit 7 is now live.
Our Upcoming Events:
Peptides Mastermind, NYC — October 4
AI Mastermind, NYC — February 17, 2026 (this will be fun!)
Members: we’re planning a Longevity Docs Tour in Miami, LA, and SF by year’s end - we believe in every physician a chance to connect in person.
Concierge: we’ve begun connecting patients directly with Longevity Docs physicians.
On Stage: proud to share the Longevity Docs mission at some of the world’s leading platforms:
Milken Institute, Hamptons — August 22–24
Vibrant Summit, Austin — September 24–27
Zenos Summit, Saudi Arabia — October 23–25
Website: we’re rebuilding the Longevity Docs website into the destination for longevity medicine: news, events, and a membership platform. A major relaunch is coming this September.
If you have questions or want to support the mission, I’d love to hear from you.
Each week, I try to explore one idea that could advance longevity medicine and hopefully support physicians in bringing it to life.
Longevity on a Budget: The 50-Cents-a-Day Longevity Promise
A VC-backed startup has launched a $199-per-year membership that promises to detect “over 1,000+ preventable conditions” through annual lab testing. Marketed as a budget version of Function Health, the pitch is seductive: for less than fifty cents a day, you can track your heart, hormones, and more.
5 reasons to be optimistic
Simplified access: navigating prescriptions and doctor’s orders for labs can be frustrating; branding and user experience can improve the experience.
Early alerts for healthy people: for those without obvious symptoms, $199 is a low-friction way to track biomarkers and catch issues before they manifest.
AI is accelerating: algorithms are rapidly improving at interpreting lab data, offering faster, scalable insights than human review alone.
Integration potential: combined with wearables and personal history, lab data could unlock genuinely personalized recommendations.
Democratizing access: if refined, services like this could make preventive health more affordable and accessible than traditional concierge care.
5 reasons to be skeptical
Labs ≠ medicine: bloodwork alone, without context or physician oversight, is not good medical care.
Generic advice is free: “Eat better, move more, sleep well” doesn’t require a $199 panel.
Liability gap: what happens if you discover sky-high cholesterol? Those companies don’t treat, because they’re not a healthcare company. That means they carry no medical liability, leaving you to find a doctor on your own.
You can get those labs for free: the same tests are typically covered by insurance when ordered through your doctor. Online you’re paying $199 just for the booking.
Behavior change is what matters: every provider knows labs don’t change habits. At best, a 100-test report is just a wake-up call.
My POV: We’re still in the early days of consumer AI in health, it is promising, but incomplete. Without physician integration, these platforms risk hijacking medicine rather than advancing it. The truth is, healthcare providers have left a vacuum: ordering labs, getting results, and writing prescriptions is often slow, expensive, and inaccessible. Nature hates emptiness, and startups are rushing to fill the gap. Of course it’s a huge market opportunity. But real scale and lasting impact will only come through systemic change that integrates providers, insurers, and health systems. Physicians have a choice: step up, partner, compete, or lose market share. The key is to stay educated, connected, and ahead of the curve.
At Longevity Docs, we believe longevity medicine is serious medicine. Prevention, interpretation, and treatment must move together guided by trusted physicians and supported by a full ecosystem of companies, investors, regulators, and health systems.
Longevity Medicine can not be discounted. Yet it should be accessible to all.
This is unfiltered look at the most engaging conversations happening in our Longevity Docs WhatsApp group.
What are your thoughts about doing TKA (Total Knee Arthroplasty) on a 90 year old woman?
Number one is get a dexa scan and see bone stock if still interested in surgical option and number 2 platelet inhibiton causes failure. If limb length prior to surgery is greater than 3 cm and surgery corrects this then expect pain in other joints
I know stem cells and peptides are controversial but bpc 157 for pain relief or subchondral injection of umbilical stem cells seem to work for some of the patients i have seen
BMC autologous IO/IA has incredible literature already on it. Allogenic sources of MSC probably have the most long term promise -- not sure which one is best yet ;) https://pubmed.ncbi.nlm.nih.gov/32322943/
Autologous in 90 year old? I can’t imagine those MSC are too robust, right?
Agree. I would use exosomes, You could also d o an rf ablation for her pain
Why would anyone use exosomes? When there is no msk data on exosomes and yet there is autologous MSc data
I’m confused..
The data is solidly on MSc, but I think the problem is the real concern with senescence in those cells
We’ve also seen great outcomes at every age with significant increase in MSc following pretreatment with Ipamorelen/CJC qhs (nothing to eat x 1 1/2 to 2 hours) 5x starting 6 weeks prior to any stem cell procedure for the last decade.
Do you think tesamorelin could give similar results prior to MSCs therapy?
I Agree I wonder if RF ablation may be a good shout here first.
Can always do a guided LA block 1st to see if that gives relief and then a good indicator for RF block.
She’s 90 (with the hx you mentioned) so I wonder what the efficacy of many of the biologic treatments will be long term?
You’d have to ask what the main outcome you are looking for is.
I’m confused why we are pushing autologous MSCs - we need to consider her age as well.Exosomes though could be a good option
I do, HGH too. We use this protocol to encourage patients to stop eating late brfore sleep which is best for physiological HGH modulation. Also ipamorelen/CJC is longer acting and the signal is parallel to GH secretion. Exogenous GH should be injected independent of exercise + sleep to avoid interfering with endogenous GH release triggered by exercise and sleep.
This is very interesting!
We don’t have access to peptides here properly ‘yet’
Do you extract and measure MSC before and after the course of peptides ?
Yes that's how we know the impact.
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Each week, I highlight a few studies that caught our eyes and could shape the future of longevity medicine.
Plasma tau biomarkers for biological staging of Alzheimer’s disease
This study highlights the potential of tau blood-based biomarkers for biological staging in AD, offering a scalable tool for tracking disease progression and guiding clinical decisions. Nature Aging
Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound
A recent study shows that low-frequency ultrasound (LFU) can reverse cellular senescence and extend lifespan in mice. By applying mechanical pressure waves, LFU restored 15 hallmarks of senescent cells, including reducing SASP, restoring telomere length, lowering oxidative stress, and normalizing DNA damage markers. Aging Cell
Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
COVID-19 is associated with early vascular ageing in the long term, especially in women. Euro Heart Journal
I comb through the mainstream headlines, handpick the most relevant longevity stories.
How ‘Optimisation’ Hijacked Men’s Wellness
We solved the problem of getting men into wellness. Now we have the bigger problem of what we’ve turned them into, writes meditation teacher Manoj Dias. Business of Fashion
Welcome to the Era of Longevity Travel: See the World and Extend Your Life Span Too!
Demand is soaring for health-focused itineraries that go beyond traditional wellness. Why just sit on a beach when you can get a diagnostic overhaul that might make you live longer? Esquire
The 2 existing drugs that could become anti-ageing pills
Billionaires and biotech are pouring billions into longevity research, with a special focus on epigenetic reprogramming and two existing drugs (rapamycin and metformin) as potential anti-aging therapies. Financial Review
Can We Beat Cancer? AI, mRNA, and the Future of Living Longer
Rubenstein delved into the breakthroughs in cancer detection and treatment, how artificial intelligence could transform prevention and early diagnosis, why cancer rates are rising among young adults, the role of mRNA vaccines in preventing and treating future cancers and the urgent challenges of health disparities and access to care. Bloomberg
Why education matters for healthy aging and longevity
Education widens the aging gap: A USC study shows that Americans without a high school diploma are biologically aging nearly twice as fast as college graduates. Education shapes lifestyle, healthcare access, and resilience, making it one of the strongest predictors of healthspan. Without intervention, disparities in longevity will continue to grow.
Every week, I track the biggest moves in longevity: new funding rounds, partnerships, product launches, and key hires.
Superpower Launches $199 Preventive Care Membership in Affordability Play
Superpower, the celebrity-backed startup, says its new $199 membership makes concierge-level preventive care and biomarker testing accessible to more people. Athletech News
Eight Sleep Secures $100 Million to Accelerate AI‑Powered Sleep Optimization, Expand Into Medical, and Grow Global Footprint
Funding accelerates the development of the world’s first AI-powered Sleep Agent, expands medical initiatives into menopausal sleep and sleep apnea, and fuels growth in international markets, including China. BusinessWire
A Common Weight Loss Drug Can Treat Severe Liver Disease, F.D.A. Says
The FDA has approved the GLP-1 drug Wegovy to treat MASH (metabolic steatohepatitis) with moderate-to-advanced fibrosis, a condition affecting 15M Americans and driving liver transplants. In trials, 63% of patients improved vs. 34% on placebo. The move positions GLP-1s beyond obesity and diabetes into systemic longevity medicine, though high costs and limited coverage remain barriers. New York Times
New high-tech wellness facility set to open in Toronto next week
A new high-tech wellness centre is set to open its doors in Toronto. Supernatural is a 5,000 sq ft facility scheduled to open in the Yorkville area next week. https://www.yourcitywithin.com/new-high-tech-wellness-facility-set-to-open-in-toronto-next-week/
Longevity Docs Peptides Mastermind
New York City | October 4, 2025
Learn from the experts: from Peptides 101: What Every Longevity Doctor Must Know to Risks, Ethics & Regulation
Longevity Docs Summit Cannes
Cannes, France | June 10-11, 2026
Conferences Calendar
ARDD: Copenhagen, August 25-29
Nubioage Clinical Longevity Summit: West Palm Beach, September 12-13, 2025
Longevity Investors Conference: Gstaad, Switzerland, September 22-25
Longevity Docs Peptides Mastermind: New York, October 4
Health Optimization Medicine Symposium: Boulder, October 17-18
Zenos Health Summit: Riyadh, October 23-25, 2025
Longevity Clinic Roundtable: Novato, December 6-8, 2025
A4M: Las Vegas, December 12-13
Hormones Mastermind Replay
For the first time, get full online access to the entire event:
✔ 10 expert-led modules
✔ Real-world protocols and case studies
✔ On-demand viewing, anytime, anywhere
No fluff, no travel: just pure, actionable hormone and longevity education.
Replay Pass: $295
Why every doctor should be a longevity doctor.
The Movement
Longevity Docs is the world’s leading collective of physicians advancing longevity medicine through education, clinical research, advisory, and exclusive experiences. With over 400 members in 50+ countries, we’re building the global infrastructure for evidence-based, personalized longevity care.
Why “Longevity Docs”?
Because we believe longevity is not a specialty — it’s a human right.
The future of medicine is proactive, not reactive. It's interdisciplinary, not isolated. It’s collaborative, data-driven, and deeply human. And it starts with us — the physicians who dare to redefine what care looks like across the decades of a patient’s life.
“Longevity Docs” isn’t just a name. It’s a statement of purpose.
Our Ecosystem
Physician Network
A trusted global collective of longevity-focused doctors exchanging protocols, referrals, and real-world clinical outcomes.Education & Certification
Earn your Certified Longevity Physician™ designation through our advanced curriculum, live masterclasses, and continuous learning tracks.Decentralized Research
Lead or participate in multicenter clinical trials and patient registries, accelerating evidence generation for healthspan optimization.Strategic Advisory
We partner with vetted longevity companies, life-science, tech, and clinics to help them grow.Global Events & Experiences
Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards
Who It’s For
Doctors → Join the club, get certified, grow your practice
Health Systems → Implement clinical longevity programs
Brands & Startups → Validate products, find advisors, run trials
Investors → Gain early access to insights, doctors, and deal flow
We’re not just witnessing the transformation of longevity medicine we’re building it. Together.
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.