10 World-Class Faculty - The AI will see you now! - Aging-related changes in the cardiovascular system
Your sneak peek into the world of Longevity Docs.
Hey Docs,
Next weekend in NYC, a handpicked circle of visionary longevity physicians will gather behind closed doors for something rare: an exclusive, intimate Mastermind dedicated entirely to Hormones & Longevity.
I wanted to build a high-trust space where only a few select physicians will get direct access to 10 world-class faculty members - sharing groundbreaking protocols, innovative therapies, and lastest research. Things they can implemented in their practice to support patients right away.
We believe this is the future of longevity medicine education: intimate, curated peer-to-peer gatherings where science meets clinical mastery, business strategy, and policy insights.
In this week’s newsletter:
❤️ Exclusive: An unforgettable Mastermind experience
💬 Buzz in the chat: Emergence and Management of Late-Onset Type 1 Diabetes (LADA)
🔥 What’s hot: The AI will see you now!
🗞️ Media: How to enhance humans
📖 Book: Adaptable - Herman Pontzer, PhD: How Your Unique Body Really Works and Why Our Biology Unites Us
Happy Sunday! And let’s advance longevity medicine, together.
🎤 Discover an unforgettable Mastermind experience
We've curated an unique experience for this edition of the Hormones Mastermind with 10 faculty, designed exclusively for our community of doctors who want to be up to date on the hormones and longevity.
Check our last Mastermind recap
Get ready for deep educational dives, open conversations with inspiring leaders, and unique networking opportunities in the heart of NYC:
Education:
Classroom: deep dives into hots topics with our experts
Mastermind: open convo with inspiring masterminds
Boardroom: a chance for every doctor to ask questions and contribute ideas
Networking:
The Club: an invite-only dinner at one of NYC’s trendiest hotspots
Agenda
Foundations of Hormonal Health for Clinical Practice
Faculty: Dr. Jessica ShepherdIdentifying Patients for Hormone Therapy
Faculty: Dr. Salome MasghatiFrom Peptides to Exosomes: Advancing Traditional HRT with the Latest Innovations
Faculty: Dr. Elizabeth YurthDesigning Safe & Effective Hormone Protocols
Faculty: Dr. Felice GershThe Science of Testosterone & Estrogen Beyond Longevity
Faculty: Dr. Angela DeRosaManaging Risks & Side Effects of Hormone Therapy
Faculty: Dr. Elizabeth PoynorThe Future of Male Hormone Therapy
Faculty: Dr. Kyle GilletNon-Hormonal Adjuncts to Optimize Hormonal Health
Faculty: Dr. Juan BautistaEstablishing a Successful Hormone Therapy Practice
Faculty: Dr. Melissa LosekeIntegrating Cutting-Edge Therapies for Your Future Practice
Faculty: Dr. Amy KillenHormones Panel
Faculty: Dr. Amy Killen, Dr. Felice Gersh, Dr. Elizabeth Yurth
🚨 Only 29 Tickets Left! 🚨
Don’t miss your chance to join the top experts in longevity medicine. Exclusive access to cutting-edge treatments, networking, and strategies to elevate your practice. Don’t be left behind - act now!
Emergence and Management of Late-Onset Type 1 Diabetes (LADA)
The conversation began when one Longevity Doc asked the community for advice regarding a 62-year-old patient who developed Type 1 Diabetes (LADA) after experiencing a cold.
Key Insights:
Several doctors highlighted a recent pattern of autoimmune diabetes (LADA) emerging after viral illnesses or COVID/vaccine exposure.
They emphasized early intervention and suggested innovative therapeutic options beyond traditional insulin therapy.
Amlexanox, a lesser-known anti-inflammatory drug has the potential to halt autoimmune beta-cell destruction and improve insulin sensitivity.
Fasting mimicking diets (FMD) were recommended as another effective intervention to potentially reverse or significantly mitigate autoimmune diabetes progression.
Clinical Takeaways:
Early treatment initiation is critical for better chances of reversing or managing LADA effectively.
Novel therapies discussed include:
GLP-1 receptor agonists (Tirzepatide): enhance endogenous insulin secretion.
Thymosin Alpha-1 (TA1): addresses autoimmune response by suppressing autoantibodies.
Amlexanox: reduces inflammation, protects beta cells, and enhances insulin sensitivity.
Hexarelin: supports pancreatic beta-cell survival.
Suggestion to reconsider standard treatment protocols, noting patients diagnosed after viral infections or vaccines might not require immediate or lifelong insulin therapy.
The Chat:
I have a patient who's husband developed Type I Diabetes at age 62. Onset was after a cold. I don't know much else outside of that. Wanted to hear if anyone had thoughts on this and any recommendations for him going forward? I don't treat Type I, so not as familiar with it.
We have a rash of vax induced LADA! GLP!s VERY helpful, TA1, and amlexanox!! Have reversed quite a few.
Amlexanox hits this on multiple mechanisms: Inhibition of IKKε and TBK1 kinases: Amlexanox inhibits these inflammatory kinases that are activated in metabolic disorders. This inhibition can reduce inflammation in pancreatic tissue, potentially slowing the autoimmune destruction of beta cells characteristic of LADA. Enhancement of insulin sensitivity: Studies suggest amlexanox may improve insulin sensitivity in peripheral tissues. This is beneficial for LADA patients who often experience insulin resistance alongside declining insulin production. The earlier you get to these people the better chance you have of reversing!
When was this 'cold'? I am seeing insulin dependent DM in many patients post COVID and post Vax…..and they actually don’t need insulin. They are being treated incorrectly……
I would start GLP-1 and wean off Insulin. I am assuming he has low insulin rather than high?
Start tirzepatide asap . can start low but work up to higher dose as tolerated. Will improve insulin secretion. Start TA 1 500mcg daily to stop autoantibodies and Amlexanox 40mg 3x daily. See how they do. Can consider adding in hexerelin. Hexarelin has shown effects on cell survival pathways that might help protect pancreatic beta cells from autoimmune destruction.
I’m a very big fan of fasting mimicking diets to reverse adult type 1.5 diabetes!! https://pubmed.ncbi.nlm.nih.gov/28235195/
Is it possible to source Amlexanox in the US?
It's not commercially available. Only certain compounding pharmacies have it.
⚠️ Limitations and Opportunities
The chat shows optimism for innovative treatments like Amlexanox, peptides, GLP-1 agonists, and fasting-mimicking diets in autoimmune diabetes management. However, these therapies face regulatory hurdles, limited published evidence, and accessibility challenges.
Significant opportunities exist to overcome these barriers through establishing patient registries, decentralized clinical trials, and structured clinician education.
Addressing these limitations while leveraging emerging opportunities will help translate promising therapies into broader clinical adoption within longevity medicine.
Private Club
Member Spotlight
Meet the Longevity Doctors Club members: physicians entrepreneurs building the future of longevity medicine one practice (or more) at the time.
Elizabeth Yurth, MD
Elizabeth Yurth, MD, is a leading voice in regenerative medicine and human optimization, serving as the Chief Medical Officer and co-founder of the Boulder Longevity Institute (BLI) since 2006. At BLI, Dr. Yurth champions advanced, research-driven medical practices, specializing in Regenerative Peptide Therapy, Next-Generation Regenerative Orthopedics, and Foundational Health Optimization.
With over 27 years of clinical expertise as an orthopedist focused on sports, spine, and regenerative medicine, Dr. Yurth is double-board certified in Physical Medicine & Rehabilitation and Anti-Aging & Regenerative Medicine. Her impressive educational background includes a Medical Degree from the University of Southern California Keck School of Medicine and residency training at the University of California – Irvine. Further enhancing her credentials, Dr. Yurth holds multiple prestigious fellowships: a Stanford-affiliated Fellowship in Sports and Spine Medicine, dual fellowships in Anti-Aging, Regenerative, and Functional Medicine (FAARM, FAARFM), a Fellowship in Human Potential and Epigenetic Medicine, and most recently, a Fellowship in Cellular and Regenerative Medicine through the Seeds Scientific Research and Performance (SSRP) Institute.
Renowned as a thought leader, Dr. Yurth regularly lectures nationwide for premier organizations like the American Academy of Anti-Aging Medicine (A4M), the International Peptide Society (IPS), and the SSRP Institute. She also contributes her expertise internationally, serving on the Scientific Advisory Board for Austria’s Longevity Labs, driving innovation in anti-aging strategies.
Passionate about lifelong learning and education, Dr. Yurth consistently engages the public through speaking events and popular health-focused podcasts, including appearances on Dave Asprey’s Upgrade Labs, Dr. Caroline Leaf’s Cleaning up Your Mental Mess, Lisa Tamati’s Pushing the Limits, and Flow Research Collective Radio. Dedicated to democratizing cutting-edge medical insights, she creates weekly content for BLI’s Human Optimization Academy, a comprehensive online educational platform.
Dr. Yurth’s extensive experience also includes consulting roles with elite sports teams, such as the San Francisco 49ers, Stanford University's women's basketball and soccer teams, Santa Clara University's basketball and soccer teams, and serving as Team Physician for the San Jose/Cleveland Ballet. Today, she continues advising professional athletes globally to enhance recovery and optimize athletic performance.
Having completed over 600 hours of Continuing Medical Education in longevity, epigenetics, nutrition, bioidentical hormone therapies, peptide treatments, regenerative orthopedics, and cellular medicine, Dr. Yurth blends her professional expertise with personal experience. As a mother of five, an athlete overcoming her own injuries, and a proactive voice navigating the challenges of aging, she authentically connects with her clients, empowering them with groundbreaking treatments designed to transform health and redefine aging. Dr. Yurth resides in Boulder, Colorado, where she continues her mission of elevating human potential.
Connect with Dr. Elizabeth Yurth
Join the Longevity Docs Club
If you’re a physician starting or scaling your longevity practice highly vetted Longevity Docs Club is for you.
Join a community of like-minded physicians and gain access to resources on marketing, finance, strategy, and technology to support your independent practice
Applications now open for MD, DO, or MBBS - Limited memberships
Global Network
Welcoming New Longevity Docs
Longevity Docs unites board-certified physicians from diverse specialties - including cardiology, endocrinology, surgery, psychiatry, public health, regenerative, and functional medicine - across private practice, academia, and health systems worldwide.
Sarah Shaw, MD - Toronto, Canada
Oyeleke Oyedotun - Scarborough, Canada
Dorien Rosiers, MD - Temse, Belgium
Lucia Cagnes, MD - Hyannis, MA, US
Sarah Jebreil, MD - Irvine, CA, USA
Chater Zoubier, MD - Tunis, Tunisia
Will House, MD - Friday Harbor, WA, USA
Irakli Ninua, MD - Tbilisi, Georgia
Dionisio Izquierdo, MD - London, UK
You are a physician(MD, DO, MBBS) interested in longevity medicine. Connect with us!
The AI Will See You Now?
Could your next doctor be… artificial?
With AI rapidly advancing, it’s no longer a sci-fi fantasy. From analyzing biomarkers to personalizing repurposing drugs (see NYT article below), AI is creeping into longevity augmenting doctors today, will it replace tomorrow?
5 Reasons AI Will Power Doctors:
Smarter diagnostics: AI can scan multiomics faster than any doctor, catching signs of disease before symptoms even show.
Hyper-personalization: it recommends uniquely tailored treatments by analyzing the patient’s unique biology and history.
Real-time behavior tracking: AI can track your patients habits, preferences, and progress - helping you stay compliant and optimizing plans in real time.
Global comparisons: it compares the case to millions of others worldwide, identifying patterns and effective treatments based on real-world data.
Always Up-to-Date: AI never sleeps. It digests the latest clinical research, drug repurposing studies, and trial data faster than any doctor ever could.
5 Reasons AI Won’t Replace Doctors:
Still needs a human prompt: AI can process data—but it needs a skilled doctor to ask the right questions and interpret complex human contexts.
Emotional intelligence: Empathy, trust, and connection can’t be coded - as of today…
Inspiration matters: motivating behavioral change requires a human touch and inspiration.
Reality check: Doctors use AI to assist (rarely to replace) direct patient care.
Ethical guidance: medical decisions are often emotional and value-based. AI isn’t ready to navigate those delicate nuances.
My prediction:
AI isn’t here to replace doctors. It’s here to empower them.
Every Doctor will be AI-powered!
The future of healthcare lies in collaboration: machines for mastery of data, humans for mastery of care. Precision without compassion and motivation is incomplete.
At Longevity Docs, we’re building the infrastructure to empower doctors in this new era - where AI enhances human judgment, not replaces it. Because even in the age of algorithms, the best medicine still starts with a conversation.
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
In this Roadmap, we delve into the organ-specific and cell-specific mechanisms that underlie ageing-related changes in the cardiovascular system. We provide guidance for the development of gerotherapeutics, which will rely on the technological progress of the diagnostic toolbox to measure residual risk in elderly individuals.
Nature Review Cardiology - Recommended by Dr. David Luu
Exploring the protective effect of metformin against sarcopenia: insights from cohort studies and genetics
This study suggests that metformin may lower sarcopenia risk, particularly in elderly patients with type 2 diabetes, with GDF15 identified as a promising target for sarcopenia treatment.
Journal of Translational Medicine - Recommended by Dr. Felice Gersh
Effect of self-paced sprint interval training and low-volume HIIT on cardiorespiratory fitness: the role of heart rate and power output
Six-weeks of self-paced SIT and LV-HIIT induce comparable improvements in CRF, body composition, arterial stiffness and glucose tolerance. Importantly, higher HR did not elicit superior changes in CRF, but PO achieved during LV-HIIT may influence improvements.
Frontiers in Physiology - Recommended by Dr. Desmond Ebanks
Ambient outdoor heat and accelerated epigenetic aging among older adults in the US
Our study provides insights into the biological underpinnings linking heat to the broader spectrum of aging-related morbidity and mortality risks. We demonstrated that short-, mid-, and long-term ambient outdoor heat can significantly accelerate epigenetic aging within a diverse, nationally representative cohort of older adults.
Science Advances - Recommended by Dr. Felice Gersh
Repurposing Amlexanox as a ‘Run the Red Light Cure-All’ with Readthrough – a ‘No-Nonsense’ Approach to Personalised Medicine
Given the safety profile of Amlexanox and ex vivo efficacy in studies thus far it is envisaged that this accepted medication shall successfully debut as an all-purpose agent for the prevention and management of human diseases.
Journal of Bioanalysis & Biomedicine - Recommended by Dr. Elizabeth Yurth
Doctors Told Him He Was Going to Die. Then A.I. Saved His Life.
AI-driven drug repurposing rapidly identified an effective treatment combination for a patient with life-threatening rare blood disorder. Led by Dr. David Fajgenbaum, this approach uses machine learning to uncover novel uses for existing medications, offering clinicians promising therapeutic options for rare and challenging cases. NYT
How to enhance humans: Finding ways to live much longer—and better—shouldn’t be left to the cranks
The recent Economist article explores how human enhancement technologies—ranging from longevity supplements to advanced gene therapies and brain-computer interfaces (BCIs)—have moved from science fiction to reality. The Economist
Adaptable - Herman Pontzer, PhD
How Your Unique Body Really Works and Why Our Biology Unites Us
I've started reading Adaptable by Herman Pontzer, and it immediately resonated with my longstanding fascination with how our environment shapes human evolution, biology, and even our societies. Pontzer takes this exploration to another level, brilliantly merging anthropology, anatomy, physiology, and modern medicine.
Pontzer dives deep into the remarkable variability of human biology and health outcomes, emphasizing our species' unique adaptability as a cornerstone of longevity medicine. He addresses critical questions that have puzzled many of us in this field:
Why do some people enjoy great health despite poor lifestyle choices, while others struggle with illness despite doing everything "right"?
How have genetic adaptations - such as increased lung capacity in Andean populations or larger spleens in Sama divers - shaped health and lifespan?
What can we learn from this vast biological diversity to improve personalized longevity treatments?
Pontzer's engaging exploration across various human physiological systems - from metabolism to immunity -challenges the idea of universal solutions and underscores the importance of tailored interventions that consider genetic and environmental contexts.
In short, Adaptable provides longevity physicians with evolutionary insights that could redefine our approach to personalized medicine, making it a valuable read for anyone committed to healthier, longer lives.
Longevity Docs Hormones Mastermind
📅 Date: March 29, 2025
📍 Location: Convene 101 Park Ave, New York (In-person & Digital Access Available)
One-day, 10-course curriculum
featuring dozen world-renowned experts, offering an unique opportunity to elevate your expertise in hormonal health and longevity medicine.
Learn directly from an unparalleled lineup of physicians, including:
Drs. Amy Killen, Jessica Shepherd, Elizabeth Yurth, Angela DeRosa, Salome Masghati, Juan Bautista, Felice Gersh, Melissa Loseke, Marcos de Andrade, Elizabeth Poynor, Kyle Gillett.
Longevity Docs Cannes
📅 Date: June 25-26, 2025
📍 Location: Palace of Festival, Cannes - France
Registrations are now open!!!
Conferences Calendar
NextMed Health: San Diego, March 30 - April 2
A4LI DC Summit: Washington DC - April 28-30
Vitalist Bay - Berkeley, CA, Apr 4 - May 29
The Longevity Med Summit - Lisbon, May 6-8
Life Summit - Berlin, May 27-28
Dublin Longevity Dummit: Dublin, July 2–4
ARDD: Coppenhagen, August 25-29
At Longevity Docs, we offer two distinct membership to support doctors in longevity medicine:
Basic Membership
Become part of a global network of 300 longevity-focused physicians across 50 countries, access to our app, educational resources, and opportunities to attend exclusive events.
Private Club Membership
For those seeking a more immersive experience, the Private Club Membership offers all the benefits of Standard Membership, plus exclusive access to private events, monthly forums, deeper collaboration with experts, and early insights into cutting-edge longevity practices.
Eligibility: Open exclusively to medical doctors operating a healthcare practice or leading a business dedicated to longevity.
Every Doctor Should be a Longevity Doctor
As a heart surgeon, I was often the doctor you hoped never to need . If you were in my operating room it means prevention was no longer an option. My father, a physician specializing in Chinese medicine and acupuncture, taught me about preventive care very early on. At 21, in 2001, I launched a foundation focused on operating on children in Africa, India, Cambodia, and Haiti so they could live longer, healthier lives.
In 2020, everything changed. When my wife contracted COVID-19, I realized the future of medicine lies in prevention. This led me to found a digital clinic dedicated to combating preventable age-related diseases, immersing myself in longevity research and new tech.
However connecting with like-minded doctors was the hardest part. I started a WhatsApp group with a dozen doctors passionate about longevity. We shared publications, new tech tools, and discussed case studies. It quickly grew into something bigger, and I realized we lacked a structured platform to learn, exchange insights, and shape the future of evidence-based longevity medicine.
From this need, Longevity Docs was born. Today, we unite 300 physicians across 50 countries with a shared goal: to democratize longevity medicine. Imagine a world where physicians have access to evidence-based practices, collaborate with experts, and conduct research together - in real-time, anywhere in the world.
I firmly believe that a decentralized, collective intelligence of physicians is the key to extending human healthspan. Together, we can create a legacy where medicine helps people live better.
Dr. David Luu
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Newsletter Disclaimer:
The content shared in this newsletter, including the "Buzz in the Chat" section, is for educational purposes only. It is derived from peer-to-peer conversations among physicians within the Longevity Docs community and is intended to inform and engage our network of doctors.
Please note that these discussions do not reflect the official position of Longevity Docs and are not to be interpreted as medical advice or recommendations. The insights and opinions shared are those of individual physicians and are provided as part of our mission to foster collaborative learning and dialogue among healthcare professionals.
We encourage all readers to consult qualified healthcare professionals for personalized medical advice and to evaluate any medical information in the context of their clinical expertise and patient needs.